Traveling-wave Transcranial Electric Stimulation
TravelingTES
Precision Transcranial Electric Stimulation for the Therapy of Cognitive Impairment
2 other identifiers
interventional
30
1 country
1
Brief Summary
This study will assess the impact of traveling wave transcranial alternating current stimulation (tACS) on working memory performance in adults.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started Sep 2022
Longer than P75 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
April 6, 2022
CompletedFirst Posted
Study publicly available on registry
June 1, 2022
CompletedStudy Start
First participant enrolled
September 5, 2022
CompletedPrimary Completion
Last participant's last visit for primary outcome
February 1, 2025
CompletedStudy Completion
Last participant's last visit for all outcomes
February 1, 2026
CompletedFebruary 4, 2025
February 1, 2025
2.4 years
April 6, 2022
February 3, 2025
Conditions
Outcome Measures
Primary Outcomes (1)
Changes in working memory performance
Changes in working memory performance (% of correct responses) as measured with the standardized N-back working memory task during active stimulation relative to pre-stimulation performance.
Immediate effect during stimulation
Secondary Outcomes (2)
Changes in reaction time
Immediate effect during stimulation
Changes in electroencephalographic (EEG) connectivity
Five minutes post-stimulation
Study Arms (4)
Frontoparietal Slow Theta Stimulation
EXPERIMENTALParticipants will receive multi-electrode transcranial alternating current stimulation over the prefrontal and parietal brain regions that induces frontal-to-parietal traveling wave at the frequency of 4 Hz with the intensity of up to 2 mA and duration up to 20 min.
Frontoparietal Fast Theta Stimulation
EXPERIMENTALParticipants will receive multi-electrode transcranial alternating current stimulation over the prefrontal and parietal brain regions that induces frontal-to-parietal traveling wave at the frequency of 7 Hz with the intensity of up to 2 mA and duration up to 20 min.
Parietofrontal Slow Theta Stimulation
EXPERIMENTALParticipants will receive multi-electrode transcranial alternating current stimulation over the prefrontal and parietal brain regions that induces parietal-to-frontal traveling wave at the frequency of 4 Hz with the intensity of up to 2 mA and duration up to 20 min.
Parietofrontal Fast Theta Stimulation
EXPERIMENTALParticipants will receive multi-electrode transcranial alternating current stimulation over the prefrontal and parietal brain regions that induces parietal-to-frontal traveling wave at the frequency of 7 Hz with the intensity of up to 2 mA and duration up to 20 min.
Interventions
Non-invasive, multi-electrode transcranial alternating current stimulation (tACS) over frontal and parietal brain areas.
Eligibility Criteria
You may qualify if:
- Age between 18 and 45 years old.
- Confident level of English language.
You may not qualify if:
- History or evidence of chronic neurological or mental disorder.
- Metal or electric implant in the head, neck, or chest area.
- History of head injuries with loss of consciousness.
- Any acute or chronic medical condition that requires ongoing pharmacological treatment.
- Pregnancy or breast-feeding.
- Alcohol or drug addiction.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- University of Minnesotalead
- Brain & Behavior Research Foundationcollaborator
Study Sites (1)
University of Minnesota
Minneapolis, Minnesota, 55455, United States
MeSH Terms
Interventions
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Ivan Alekseichuk, PhD
University of Minnesota
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- TRIPLE
- Who Masked
- PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
- Purpose
- BASIC SCIENCE
- Intervention Model
- CROSSOVER
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
April 6, 2022
First Posted
June 1, 2022
Study Start
September 5, 2022
Primary Completion
February 1, 2025
Study Completion
February 1, 2026
Last Updated
February 4, 2025
Record last verified: 2025-02
Data Sharing
- IPD Sharing
- Will share
- Time Frame
- Data will be shared only upon request after the study has ended (within 6 months).
- Access Criteria
- To receive access, the study investigators need to be contacted via an institutional e-mail including a short description of the scientific or educational aims.
Full or partial access to the preprocessed data will be provided upon the request to the faculty / research staff of recognized research, medical, and educational institutions for educational and scientific purposes. The request should be sent via an institutional email and will be stored with the study materials. The request should include a short description of the scientific or educational aims.