NCT05397327

Brief Summary

Tibial plateau fractures are often complex fractures and need a good preoperative planning. The investigators think that a 3D virtual planning software will help the surgeons to get a better understanding of the fracture and therefore want to study the value of 3D virtual planning software in the preoperative planning of tibial plateau fractures. The investigators hypothesize that this software will shorten the duration of surgery, decrease the peroperative bloodloss and the number of complications. Patients with tibial plateau fractures who need surgical treatment will be asked to participate in this study. After participants have given informed consent, they will be randomized between a 'traditional preoperative planning' and a '3D virtual preoperative planning' group. Surgeons will plan their surgery using traditional planning tools (X-rays and CT scan) or traditional planning tools ánd the 3D virtual planning software. 6 weeks, 3 months and 6 months after surgery, participants will be asked to fill in 2 questionnaires about knee pain and knee function. After surgery a CT scan or X-ray will be performed conform standard of care in the hospital.

Trial Health

47
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
70

participants targeted

Target at P50-P75 for not_applicable

Timeline
Completed

Started Jun 2022

Geographic Reach
3 countries

3 active sites

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

May 10, 2022

Completed
21 days until next milestone

First Posted

Study publicly available on registry

May 31, 2022

Completed
1 day until next milestone

Study Start

First participant enrolled

June 1, 2022

Completed
1 year until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 1, 2023

Completed
6 months until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2023

Completed
Last Updated

May 31, 2022

Status Verified

May 1, 2022

Enrollment Period

1 year

First QC Date

May 10, 2022

Last Update Submit

May 25, 2022

Conditions

Outcome Measures

Primary Outcomes (1)

  • Duration of surgery

    Time in minutes from start of surgery till end of surgery

    Intraoperative

Secondary Outcomes (7)

  • Blood loss

    Intraoperative

  • Surgical complications

    up to 30 days postoperative

  • Perioperative deviations

    Immediately after x-ray or CT scan is performed

  • Quality of reduction

    Immediately after x-ray or CT scan is performed

  • Quality of reduction

    Immediately after x-ray or CT scan is performed

  • +2 more secondary outcomes

Study Arms (2)

Conventional planning group

NO INTERVENTION

Conventional preoperative planning using x-rays and 2D and 3D CT scan

3D virtual planning group

EXPERIMENTAL

Preoperative planning using x-rays, 2D and 3D CT scans and 3D virtual planning software

Other: 3D virtual planning software

Interventions

3D virtual planning software developed by Sectra AB (Linköping, Sweden)

3D virtual planning group

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Adult patients of 18 years or older with a tibial plateau fracture who will receive surgical treatment for this fracture

You may not qualify if:

  • patients with (general) bone diseases or osseous malformation syndromes,
  • ipsilateral limb fractures,
  • complicated tibial plateau fractures that need an external fixator,
  • previous tibial plateau fractures
  • previous surgical treatment of the tibial plateau

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (3)

Massachusetts General Hospital

Boston, Massachusetts, 02114, United States

Location

Flinders Medical Center

Adelaide, South Australia, 5042, Australia

Location

Radboud University Medical Center

Nijmegen, Gelderland, 6525GA, Netherlands

Location

MeSH Terms

Conditions

Tibial Plateau Fractures

Condition Hierarchy (Ancestors)

Knee FracturesFractures, BoneWounds and InjuriesTibial FracturesKnee InjuriesLeg Injuries

Study Officials

  • Job Doornberg, Professor

    University Medical Center Groningen

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Job Doornberg, Professor

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
PARTICIPANT, OUTCOMES ASSESSOR
Purpose
OTHER
Intervention Model
PARALLEL
Model Details: Randomized controlled trial
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

May 10, 2022

First Posted

May 31, 2022

Study Start

June 1, 2022

Primary Completion

June 1, 2023

Study Completion

December 1, 2023

Last Updated

May 31, 2022

Record last verified: 2022-05

Data Sharing

IPD Sharing
Will share

We will use the digital research environment (DRE), developed by a collaboration of hospitals in the Netherlands, to share anonymized individual participant data between the three participating centers. Participant data that will be shared is: * 3D Virtual planning software * Time spent planning * Fracture Characteristics * Surgeon satisfaction * Patient Demographics * Age * Sex * Mechanism of injury * Comorbidities * BMI * Duration of surgery * Number of complications * Perioperative deviations * Quality of reduction * Knee pain and function * Surgeon characteristics * Area of practice * Sex * Specialization * Years in practice

Shared Documents
STUDY PROTOCOL, SAP, ICF, CSR, ANALYTIC CODE
Time Frame
Data will become available after inclusion of the first patient. The data will be vailable until 6 months after inclusion of the last patient
Access Criteria
Only the research team will have access to the data
More information

Locations