COPD Circuit Exercise

NCT05395390 | Completed

• 1 other identifier: 2019-0149
• Study Type: interventional
• Target: 72
• Locations: 1 country
• Sites: 1

Brief Summary

This study is being done to understand body's response to hybrid home-based and on-site rehabilitation program utilizing individually tailored exercises throughout a total of 18 sessions with 12 of them occurring onsite, in people with and without chronic respiratory diseases, such as Chronic Obstructive Pulmonary Disease (COPD) and Obstructive Sleep Apnea (OSA) and in individuals recovered from COVID-19. Exercise training programs vary widely for people with COPD, OSA, and during prolonged recovery from COVID infection. This study will help identify if this program is helpful to address muscle loss and fatigue specifically in populations with and without chronic respiratory diseases.

Conditions

OSA; Covid19; Residual Symptoms of COVID 19; COPD

Outcome Measures

Primary Outcomes (1)

• Whole-body protein and amino acid metabolism response to training

  Whole-body production rate measured after stable tracer administration

  up to 8 weeks Exercise Intervention

Secondary Outcomes (21)

• Body Composition using Dual Energy X-Ray Absorptiometry bone density

  up to 8 week Exercise Intervention

• Body Composition using Dual Energy X-Ray Absorptiometry Muscle

  up to 8 week Exercise Intervention

• Body Composition using Dual Energy X-Ray Absorptiometry Fat

  up to 8 week Exercise Intervention

• Bone mineral density by BIA

  up to 8 week Exercise Intervention

• Handgrip strength dynamometry by Handgrip Dynamometer

  up to 8 week Exercise Intervention

Interventions

Exercise (Resistance Training BEHAVIORAL

Resistance Training done both at home and on site using either dumbells or keiser pneumatic exercise machines respectively

Eligibility Criteria

• Age: 30 Years - 85 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Ability to walk, sit down and stand up independently
• Age 30 - 85 years
• Ability to lay in supine or elevated position for up to 3 hours
• Diagnosis of moderate to very severe chronic airflow limitation and compliant to the following criteria: FEV1 \< 70% of reference FEV1
• or- Obstructive Sleep Apnea (OSA)
• or- 2 weeks post-recovered\* from laboratory confirmed case of COVID
• ● Willingness and ability to comply with the protocol
• \*Recovered is defined according to Brazos County Health District as someone who has been fever-free for 24 hours without fever-reducing medications, and it has been 10 days after onset of symptoms.
• Healthy male or female according to the investigator's or appointed staff's judgment
• Ability to walk, sit down and stand up independently
• Age 30 - 85 years
• Ability to lay in supine or elevated position for up to 3 hours
• No diagnosis of chronic lung disease
• Willingness and ability to comply with the protocol

You may not qualify if:

• Unable to exercise due to physical limitations (i.e. neuromuscular and/or orthopedic disorders)
• Established diagnosis of malignancy
• Presence of acute illness or metabolically unstable chronic illness
• Presence of fever within the last 3 days.
• Expected to have surgery within 1 month of screening or during exercise training
• Any other condition according to the PI or research staff that was found during the screening visit, that would interfere with the study or safety of the patient.
• Previous injury that could interfere with participation in resistance exercise protocol.
• Failure to give informed consent or Investigator's uncertainty about the willingness or ability of the subject to comply with the protocol requirements.
• (Possible) pregnancy.

Sponsors & Collaborators

• Texas A&M University: lead

Study Sites (1)

Texas A&M University

College Station, Texas, 77843, United States

Location

Related Publications (1)

• Yu AK, Deutz NEP, Perez CN, DeWandel S, Ruebush LE, Engelen MPKJ. The acute effects of alpha-lactalbumin intake on tryptophan metabolites and mood in older adults with Mild Cognitive Impairment. Nutr Neurosci. 2025 Sep 14:1-15. doi: 10.1080/1028415X.2025.2554359. Online ahead of print.

  PMID: 40946231 DERIVED

MeSH Terms

Conditions

COVID-19; Pulmonary Disease, Chronic Obstructive

Interventions

Exercise; Resistance Training

Condition Hierarchy (Ancestors)

Pneumonia, Viral; Pneumonia; Respiratory Tract Infections; Infections; Virus Diseases; Coronavirus Infections; Coronaviridae Infections; Nidovirales Infections; RNA Virus Infections; Lung Diseases; Respiratory Tract Diseases; Lung Diseases, Obstructive; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena; Exercise Therapy; Rehabilitation; Aftercare; Continuity of Patient Care; Patient Care; Therapeutics; Physical Therapy Modalities; Physical Conditioning, Human

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: December 10, 2021
• First Posted: May 27, 2022
• Study Start: February 2, 2021
• Primary Completion: August 7, 2023
• Study Completion: August 7, 2023
• Last Updated: September 30, 2025

Record last verified: 2025-09

Locations

US (1)