Rural South and Southeast Asia Household Health Survey

NCT05389540 | Completed

• 1 other identifier: HCR21013
• Study Type: observational
• Target: 4,747
• Locations: 4 countries
• Sites: 4

Brief Summary

A cross-sectional household survey with two-stage cluster-randomized sampling. This cross-sectional household survey design to recruit a random sample of households that is representative for each of the study sites. From the selected households, all consenting, household members will be included in the study. This study is funded by the UK Wellcome Trust. The grant reference number is 215604/Z/19/Z

Conditions

Noncommunicable Disease; Infections; Risk Factors; Health Status

Keywords

Cross-sectional household survey

Outcome Measures

Primary Outcomes (10)

• Prevalence of long-lasting antibodies (IgG) against selected causes of non-malaria febrile illnesses

  Upon enrollment

• Prevalence of Plasmodium spp. by PCR

  Upon enrollment

• Prevalence of chronic Hepatitis B and C

  Upon enrollment

• Prevalence of selected non-communicable diseases (e.g. diabetes, chronic obstructive pulmonary diseases, stroke) according to self-reported disease history and laboratory tests

  Upon enrollment

• Prevalence of reported disability

  Upon enrollment

• Lifetime prevalence of reported injury or death caused by an accident

  Upon enrollment

• Self-rated overall health status

  Upon enrollment

• Questionnaire evaluation of health-related quality of life

  Upon enrollment

• Prevalence of self-reported tobacco, alcohol, and other substitute use among the population aged 15 and above

  Upon enrollment

• Prevalence of underweight and overweight, raised blood pressure and total cholesterol

  Upon enrollment

Secondary Outcomes (11)

• Evaluation of household wealth quartile according to self-reported household characteristics

  Upon enrollment

• Education level, marital status, and occupation

  Upon enrollment

• Self-reported health-related household characteristics (e.g. household cooking fuel, source of drinking water, possession of mosquito net)

  Upon enrollment

• Proportion of population self-reported having sought for medical care in the past month, and care providers visited

  Upon enrollment

• Self-reported antenatal care coverage among women who have ever given birth

  Upon enrollment

Study Arms (1)

members of selected households at the time of survey

371 households will be randomly selected from each site in Bangladesh, Cambodia, Myanmar, and Thailand. Assuming each household has an average of 4.5 members and all members will be sampled, 1500 participants will be recruited per site.

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Households located in the survey villages and identified in the household list are eligible for the survey. All members of the randomly selected households will be recruited

You may qualify if:

• All members of the selected households at the time of the survey; and able to provide informed consent.

You may not qualify if:

• Adults or children whose parent/guardian/ caretaker are unable or unwilling to provide informed consent.

Sponsors & Collaborators

• University of Oxford: lead
• Mahidol Oxford Tropical Medicine Research Unit: collaborator
• Chiang Rai Clinical Research Unit, Thailand: collaborator
• Myanmar Oxford Clinical Research Unit, Yangon, Myanmar: collaborator
• Bangladesh Rural Advancement Committee, Dhaka, Bangladesh: collaborator
• Cambodia Action for Health Development (AHEAD): collaborator

Study Sites (4)

BangladeshBuilding Resources Across Communities (BRAC)

Dhaka, 1212, Bangladesh

Location

Medical Action Myanmar (MAM)

Yangon, 11201, Burma

Location

Cambodia Action for Health Development (AHEAD)

Battambang, Cambodia

Location

Chiangrai Clinical Research Unit (CCRU)

Chiang Rai, 57000, Thailand

Location

Related Publications (2)

• Chandna A, Chew R, Shwe Nwe Htun N, Peto TJ, Zhang M, Liverani M, Brummaier T, Phommasone K, Perrone C, Pyae Phyo A, Sattabongkot J, Roobsoong W, Nguitragool W, Sen A, Ibna Zaman S, Sandar Zaw A, Batty E, Waithira N, Abdad MY, Blacksell SD, Bodhidatta L, Callery JJ, Fagnark W, Huangsuranun W, Islam S, Lertcharoenchoke S, Lohavittayavikant S, Mukaka M, Moul V, Kumer Neogi A, Nedsuwan S, Pongvongsa T, Ponsap P, Richard-Greenblatt M, Schilling WHK, Thaipadungpanit J, Tripura R, Dondorp AM, Mayxay M, White NJ, Nosten F, Smithuis F, Ashley EA, Maude RJ, Day NPJ, Lubell Y. Defining the burden of febrile illness in rural South and Southeast Asia: an open letter to announce the launch of the Rural Febrile Illness project. Wellcome Open Res. 2022 Mar 10;6:64. doi: 10.12688/wellcomeopenres.16393.2. eCollection 2021.

  PMID: 34017924 BACKGROUND

• Zhang M, Htun NSN, Islam S, Sen A, Islam A, Neogi AK, Tripura R, Dysoley L, Perrone C, Chew R, Batty EM, Thongpiam W, Wongsantichon J, Menggred C, Zaman SI, Waithira N, Blacksell S, Liverani M, Lee S, Maude RJ, Day NPJ, Lubell Y, Peto TJ. Defining the hidden burden of disease in rural communities in Bangladesh, Cambodia and Thailand: a cross-sectional household health survey protocol. BMJ Open. 2024 Mar 23;14(3):e081079. doi: 10.1136/bmjopen-2023-081079.

  PMID: 38521526 DERIVED

Related Links

• Related Info

Biospecimen

Retention: SAMPLES WITH DNA

Venous blood samples and Dried blood spot

MeSH Terms

Conditions

Noncommunicable Diseases; Infections

Condition Hierarchy (Ancestors)

Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Yoel Lubell, Professor

  Mahidol Oxford Tropical Medicine Research Unit

  PRINCIPAL INVESTIGATOR

• Thomas Peto, PhD

  Mahidol Oxford Tropical Medicine Research Unit

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: ECOLOGIC OR COMMUNITY
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 19, 2022
• First Posted: May 25, 2022
• Study Start: October 3, 2022
• Primary Completion: December 10, 2023
• Study Completion: December 10, 2023
• Last Updated: February 28, 2024

Record last verified: 2024-02

Data Sharing

• IPD Sharing: Will share
• Time Frame: After completion of survey activities and reporting
• Access Criteria: MORU Data Sharing Policy

Locations

CA (1); BU (1); TH (1); BA (1)