NCT05380570

Brief Summary

Health risks of radiation exposure in the moderate-to-high dose range have been well established. However, the risk remains unclear at low-dose ranges with protracted low-dose rate exposure, which is typical of occupational exposure. The purpose of this study is to construct a cohort of Korean radiation workers and to assess health effects associated with occupational radiation exposure. The study population is expected to be about 190,000 Korean radiation workers who have been registered with the Nuclear Safety and Security Commission since 1984. The national dose registry, the national cancer registry, the national vital statistics registry, and the national health insurance data are collected based on the Nuclear Safety Act. Through the linkage of those collected data, we will evaluate radiation-induced health risks including cancer and non-cancer diseases.

Trial Health

75
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
196,379

participants targeted

Target at P75+ for all trials

Timeline
58mo left

Started Nov 2021

Longer than P75 for all trials

Geographic Reach
1 country

1 active site

Status
active not recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress49%
Nov 2021Mar 2031

Study Start

First participant enrolled

November 18, 2021

Completed
6 months until next milestone

First Submitted

Initial submission to the registry

May 9, 2022

Completed
10 days until next milestone

First Posted

Study publicly available on registry

May 19, 2022

Completed
8 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 31, 2022

Completed
8.3 years until next milestone

Study Completion

Last participant's last visit for all outcomes

March 31, 2031

Expected
Last Updated

April 20, 2026

Status Verified

March 1, 2026

Enrollment Period

1.1 years

First QC Date

May 9, 2022

Last Update Submit

April 15, 2026

Conditions

Occupational Exposure to RadiationNeoplasms, Radiation-InducedLeukemia, Radiation-InducedRadiation Effects

Keywords

Ionizing radiationCohort studyRadiation workersRadiation-Induced diseases

Outcome Measures

Primary Outcomes (2)

  • Radiation-induced cancer risk

    Cancer risk associated with occupational radiation exposure

    year 4

  • Radiation-induced cancer risk

    Cancer risk associated with occupational radiation exposure

    year 9

Secondary Outcomes (2)

  • Radiation-induced non-cancer risk

    year 4

  • Radiation-induced non-cancer risk

    year 9

Study Arms (1)

Korean radiation workers

The study population is Korean radiation workers exposed to ionizing radiation in workplaces. Diagnostic medical radiation workers were not included in the study population.

Radiation: Occupational radiation exposure

Interventions

Occupational radiation exposureRADIATION

Ionizing radiation in workplaces

Korean radiation workers

Eligibility Criteria

Age16 Years+
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Korean radiation workers in the national dose registry

You may qualify if:

  • Korean radiation workers in the national dose registry (except for diagnostic medical radiation workers)

You may not qualify if:

  • Unidentified personal identification numbers
  • Foreigner

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Korea Institute of Radiological & Medical Sciences

Seoul, Nowon-gu, 01812, South Korea

Location

Related Publications (2)

  • Seo S, Lim WY, Lee DN, Kim JU, Cha ES, Bang YJ, Lee WJ, Park S, Jin YW. Assessing the health effects associated with occupational radiation exposure in Korean radiation workers: protocol for a prospective cohort study. BMJ Open. 2018 Mar 30;8(3):e017359. doi: 10.1136/bmjopen-2017-017359.

    PMID: 29602835BACKGROUND

  • Lee D, Cha ES, Park S, Sung H, Noh E, Jeong H, Jang WI, Seo S. Cohort Profile: The Korean Radiation Workers Study (KRWS). Int J Epidemiol. 2024 Apr 11;53(3):dyae060. doi: 10.1093/ije/dyae060. No abstract available.

    PMID: 38628072RESULT

MeSH Terms

Conditions

Neoplasms, Radiation-InducedLeukemia, Radiation-Induced

Condition Hierarchy (Ancestors)

NeoplasmsRadiation InjuriesWounds and InjuriesLeukemiaNeoplasms by Histologic TypeHematologic DiseasesHemic and Lymphatic Diseases

Study Officials

  • Songwon Seo, Ph.D.

    Korea Institute of Radiological & Medical Sciences

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER GOV
Responsible Party
SPONSOR

Study Record Dates

First Submitted

May 9, 2022

First Posted

May 19, 2022

Study Start

November 18, 2021

Primary Completion

December 31, 2022

Study Completion (Estimated)

March 31, 2031

Last Updated

April 20, 2026

Record last verified: 2026-03

Data Sharing

IPD Sharing
Will not share

Locations

KR(1)