NCT05375877

Brief Summary

The present study aims to investigate whether care improvement in patients after catheter ablation/cardioversion compared with standard care can be realized by using a digital eHealth platform with connected mobile sensors through early detection of atrial fibrillation recurrence and patient empowerment.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
270

participants targeted

Target at P50-P75 for not_applicable cardiovascular-diseases

Timeline
Completed

Started Feb 2022

Typical duration for not_applicable cardiovascular-diseases

Geographic Reach
1 country

3 active sites

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

February 3, 2022

Completed
11 days until next milestone

First Submitted

Initial submission to the registry

February 14, 2022

Completed
3 months until next milestone

First Posted

Study publicly available on registry

May 17, 2022

Completed
1.7 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 31, 2024

Completed
6 months until next milestone

Study Completion

Last participant's last visit for all outcomes

July 31, 2024

Completed
Last Updated

April 21, 2023

Status Verified

April 1, 2023

Enrollment Period

2 years

First QC Date

February 14, 2022

Last Update Submit

April 20, 2023

Conditions

Keywords

eHealthcardiologyatrial fibrillation

Outcome Measures

Primary Outcomes (1)

  • Superiority of the iATROS platform as compared to the standard of care

    Assessment of atrial fibrillation recurrences and attribution to detection system. Clinically relevant superiority of one system over the other is defined at an allocation of ≥75% of all arrhythmic events to either system.

    12 months to a maximum of 24 months

Other Outcomes (10)

  • Patient adherence

    12 months to a maximum of 24 months

  • Disease progression

    12 months to a maximum of 24 months

  • EHRA-Score

    Baseline and study completion, an average of 1 year

  • +7 more other outcomes

Study Arms (1)

Digital eHealth platform with connected mobile 1-lead ECGs + Standard of Care

OTHER

Patients will be fitted with a 1-channel ECG monitor after inclusion in the study and discharged to post ablation care. Here, ECGs are recorded regularly until the occurrence of an arrhythmic event. After the occurrence of an event, a discussion with the investigator will be performed. Interim medical contacts will be limited to the agreed-upon follow-up appointments for the long-term ECGs and other appointments routinely scheduled in the patient's care according to the Standard of Care. long-term ECGs at defined time points

Device: iATROS

Interventions

iATROSDEVICE

The digital eHealth platform of iATROS in combination with a wearable will be used independently by the subjects of the study. In particular, the reminder function is used to remind patients to record their ECGs, take medication and perform other tasks they may have created themselves, or to use other iATROS functions, such as teleconsultation or remote medical data reporting. Furthermore, the designed training program for atrial fibrillation patients teaches them how to deal with their own disease. If unhealthy or dangerous vital signs are detected during the use of these medical devices over a longer period of time, the patient receives feedback through the application for medical presentation. This includes the detection of atrial fibrillation recurrences.

Digital eHealth platform with connected mobile 1-lead ECGs + Standard of Care

Eligibility Criteria

Age18 Years - 89 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • ≥ 18 years
  • Diagnosis of atrial fibrillation according to ICD-10 I48.0, I48.1, I48.2, or I48.9.
  • Possession and use of a smartphone that allows installation and use of the iATROS app.
  • Possession of the physical and mental abilities to use and apply the iATROS app.
  • Patients undergoing ablation or cardioversion after a confirmed diagnosis of atrial fibrillation.

You may not qualify if:

  • \< 18 years
  • No use of a smartphone
  • Lack of the physical and mental abilities necessary to use the iATROS app, or to use so-called "apps" on a smartphone or tablet computer in general
  • Absolute contraindications:
  • Tumor disease
  • immunosuppression
  • Dementia in an advanced stage
  • Any disease associated with a reduced life expectancy of less than 1 year
  • Any disease/condition that restricts participation in the study
  • Pregnant or breastfeeding patients
  • Participation in another clinical trial
  • Addictive diseases
  • Stroke in the last 3 months
  • Transient ischemic attack (TIA) in the last 3 months

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (3)

Internistisches Zentrum Ebersberg

Ebersberg, Bavaria, 85560, Germany

RECRUITING

Isar Herz Zentrum, ISAR Klinikum

Munich, Bavaria, 80331, Germany

RECRUITING

Klinikum rechts der Isar of the Technical University of Munich

Munich, Bavaria, 81675, Germany

RECRUITING

MeSH Terms

Conditions

Cardiovascular DiseasesAtrial Fibrillation

Condition Hierarchy (Ancestors)

Arrhythmias, CardiacHeart DiseasesPathologic ProcessesPathological Conditions, Signs and Symptoms

Central Study Contacts

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Purpose
TREATMENT
Intervention Model
SINGLE GROUP
Model Details: Prospective, multicenter, longitudinal study with event-based design
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

February 14, 2022

First Posted

May 17, 2022

Study Start

February 3, 2022

Primary Completion

January 31, 2024

Study Completion

July 31, 2024

Last Updated

April 21, 2023

Record last verified: 2023-04

Data Sharing

IPD Sharing
Will not share

Locations