Mobility and Voiding Exercises in Older Women With Urinary Incontinence (MoVEonUp)

NCT05375344 | Active Not Recruiting

• 1 other identifier: 849788
• Study Type: interventional
• Target: 375
• Locations: 1 country
• Sites: 1

Brief Summary

A prospective, two-arm randomized clinical trial utilizing a multidimensional intervention to reduce falls in older women with Urinary Urge Incontinence. The intervention consist of general balance and strength training, bladder training and urge suppression, and home hazard assessments. The control group will receive informational booklets on fall prevention and behavioral treatment for urinary urge incontinence.

Conditions

Urinary Incontinence, Urge

Outcome Measures

Primary Outcomes (1)

• Change in number of falls between the baseline visit and 1 year

  number of falls reported in a falls diary

  12 months

Secondary Outcomes (1)

• Change in urinary incontinence score on the International Consultation on Incontinence Questionnaire Short Form (ICIQ-SF) between baseline visit and 1 year

  12 months

Study Arms (2)

Exercise Group

ACTIVE COMPARATOR

Participants in this group will participate in the home-based exercise group intervention that consists of general balance and strength training, bladder training and urge suppression, and home hazard assessments.

Behavioral: Exercise Group

Control Group

NO INTERVENTION

Participants in this group will receive informational booklets on fall prevention and behavioral treatment for Urgency Incontinence.

Interventions

Exercise Group BEHAVIORAL

Home-based exercise group intervention

Exercise Group

Eligibility Criteria

• Age: 70 Years+
• Sex: female
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)

You may qualify if:

• Female
• or older
• Living independently in the community
• Willingness to be randomized.
• Ability to read and understand English
• Be able to provide informed consent
• Low physical activity (physically active for 30 minutes or more less than or equal to 2 days per week on average over the past 6 months) per PAS
• Ambulatory (defined as patient not confined to bed or wheelchair OR ability to walk with or without an assistive device)
• Self-reported moderate to severe urge-predominant UI based on the ICIQ-SF \> 6 (Q 1+2+3)
• Not planning to initiate new UI or overactive bladder (OAB) treatment during the study duration
• Capable of participation in an exercise program without exacerbating any pre-existing condition(s), as determined by the study PI or designee

You may not qualify if:

• Pelvic organ prolapse passed the hymen (per patient report)
• Undergoing active treatment for cancer (other than non-melanoma skin cancer)
• Uncorrected visual or hearing loss.
• Other urinary conditions or procedures that may affect continence status for example: urethral diverticulum, previous augmentation cystoplasty
• Progressive neurodegenerative disease e.g. Parkinson's disease, multiple sclerosis per patient report
• History of stroke or carotid sensitivity (i.e. syncopal falls) per patient report
• Unstable cardiac disease per patient report
• Fracture or joint replacement within the last six months per patient report
• Significant cognitive impairment (defined as a modified TICs score of \< 27)
• Per PI discretion, participant cannot enroll in study

Sponsors & Collaborators

• University of Pennsylvania: lead

Study Sites (1)

University of Pennsylvania

Philadelphia, Pennsylvania, 19104, United States

Location

Related Publications (1)

• Andy UU, Newman DK, Wyman JF, Klusaritz H, Walsh W, Shou H, Koepler N, Schmitz KH, Reaves S, Arya L, Brown RT. The Mobility and Voiding Exercises in Older Women with Urinary Incontinence (MoVEonUp) randomized controlled trial: study protocol and rationale. BMC Geriatr. 2024 Dec 4;24(1):994. doi: 10.1186/s12877-024-05552-7.

  PMID: 39633261 DERIVED

MeSH Terms

Conditions

Urinary Incontinence, Urge

Condition Hierarchy (Ancestors)

Urinary Incontinence; Urination Disorders; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Lower Urinary Tract Symptoms; Urological Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Uduak U Andy, MD

  University of Pennsylvania

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: May 10, 2022
• First Posted: May 16, 2022
• Study Start: June 9, 2022
• Primary Completion (Estimated): September 1, 2026
• Study Completion (Estimated): September 1, 2026
• Last Updated: February 5, 2026

Record last verified: 2026-01

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)