Relationship of PNI and Clinical Outcome in Patients Undergoing Brain Tumor Surgery

NCT05373836 | Completed DMC

• 1 other identifier: PNI_Brain tumor
• Study Type: observational
• Target: 3,263
• Locations: 1 country
• Sites: 1

Brief Summary

There are several predictors of clinical outcome in patients undergoing brain tumor surgery. Among those, nutritional parameters and calculated nutritional index are known to have ability to predict mortality and clinical outcomes in some patients with brain tumor. However, there are lack of consistent results on predictability of nutritional index and clinical outcome in patients undergoing brain tumor surgery.

Conditions

Clinical Outcome

Keywords

nutritional index; brain tumor surgery; mortality

Outcome Measures

Primary Outcomes (1)

• predictability of prognostic nutritional index for mortality after brain tumor surgery

  Odds ratio of prognostic nutritional index for postoperative mortality

  From date of surgery until the date of death from any cause, whichever came first, assessed up to 50 years

Secondary Outcomes (3)

• predictability of prognostic nutritional index for acute kidney injury after brain tumor surgery

  From date of surgery until the date of acute kidney injury from any cause, whichever came first, assessed up to 50 years

• predictability of prognostic nutritional index for renal replacement therapy after brain tumor surgery

  From date of surgery until the date of renal replacement therapy from any cause, whichever came first, assessed up to 50 years

• relationship of prognostic nutritional index for length of hospital stay after brain tumor surgery

  From date of surgery until the date of hospital discharge

Study Arms (1)

brain tumor surgery

adult patients undergoing brain tumor surgery

Diagnostic Test: prognostic nutritional index calculated from laboratory parameters

Interventions

prognostic nutritional index calculated from laboratory parameters DIAGNOSTIC_TEST

Calculated nutritional index using laboratory results of serum albumin, lymphocyte count, and cholesterol

brain tumor surgery

Eligibility Criteria

• Age: 20 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients undergoing brain tumor surgery at Seoul National University Hospital, South Korea

You may qualify if:

• adult patients undergoing brain tumor surgery at Seoul National University Hospital, South Korea

You may not qualify if:

• Lack of results of laboratory parameters, such as serum albumin, lymphocyte count, cholesterol
• Lack of data on clinical outcome, including mortality, acute kidney injury, renal replacement therapy, length of hospital stay, and other major adverse outcome

Sponsors & Collaborators

• Seoul National University Hospital: lead

Study Sites (1)

Seoul National University Hospital

Seoul, 03080, South Korea

Location

Study Officials

• Youn Joung Cho, MD, PhD

  Seoul National University Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Clinical Associate Professor

Study Record Dates

• First Submitted: April 24, 2022
• First Posted: May 13, 2022
• Study Start: December 12, 2024
• Primary Completion: December 1, 2025
• Study Completion: December 31, 2025
• Last Updated: February 12, 2026

Record last verified: 2026-02

Locations

KR (1)