NCT05370014

Brief Summary

This study tests the efficacy of a dyadic intervention to mitigate the adverse health consequences of severe acute respiratory syndrome coronavirus 2 (SARS- CoV-2 )(COVID-19) in African American (AA) adults with pre-existing chronic health conditions and their informal carepartners (IC). Socioeconomically disadvantaged, older, and Black/African American from rural regions are burdened with greater rates of chronic diseases such as diabetes, hypertension, chronic kidney disease, cardiovascular disease, and stroke.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
500

participants targeted

Target at P75+ for not_applicable

Timeline
1mo left

Started Jan 2023

Longer than P75 for not_applicable

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Progress96%
Jan 2023Jun 2026

First Submitted

Initial submission to the registry

April 14, 2022

Completed
27 days until next milestone

First Posted

Study publicly available on registry

May 11, 2022

Completed
8 months until next milestone

Study Start

First participant enrolled

January 3, 2023

Completed
3.4 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 30, 2026

Expected
1 month until next milestone

Study Completion

Last participant's last visit for all outcomes

June 30, 2026

Last Updated

May 16, 2025

Status Verified

May 1, 2025

Enrollment Period

3.4 years

First QC Date

April 14, 2022

Last Update Submit

May 13, 2025

Conditions

Keywords

health inequitiesruralBlack/African Americandyadsstructural determinants of healthquality of life

Outcome Measures

Primary Outcomes (1)

  • Change in patient-reported outcomes measurement information system (PROMIS) Global Health Scale

    Quality of Life 10 items. minimum score 4 to maximum score 20. Higher scores mean better.

    0, 4, 7 months

Secondary Outcomes (8)

  • Change in PROMIS Short Form v1.0 Anxiety

    0, 4, 7 months. minimum score 6 to maximum score 30. lower scores mean better.

  • Change in Center for Epidemiologic Studies Depression Scale (CES-D)

    0, 4, 7 months

  • Change in PROMIS Short Form v1.0 Fatigue

    0, 4, 7 months

  • Change in PROMIS Short From v1.0 Sleep Disturbance

    0, 4, 7 months

  • Change in PROMIS Short Form v.1.1 Pain interference

    0, 4, 7 months

  • +3 more secondary outcomes

Study Arms (2)

iCINGS Fam Intervention

EXPERIMENTAL

Integrating Community-based Intervention Under Nurse Guidance with Families (iCINGS FAM) is 14-week, nurse coordinated, Community Health Worker (CHW) supported telehealth intervention structure. After baseline assessment, dyads randomized to the intervention group (n= 125 dyads) will have two planning sessions (over 2 weeks) followed by eight topic-guided sessions delivered by a member of the RN-CHW team over 12 weeks (weekly the first 4 weeks, then bi-weekly), Follow up assessments will occur at month 4 and month 7.

Behavioral: Integrating Community-based Intervention Under Nurse Guidance with Families (iCINGS FAM)

Attention Control

NO INTERVENTION

After baseline assessment, dyads randomized to the attention control group (n= 125 dyads) will receive monthly (3 in total; 7-10 min each) scripted phone calls on focused on general health risks and health promotion. Monthly telephone calls will cover readily accessible evidence-based public health messaging from the Centers for Disease Control and Prevention (CDC) Your Health, NIH and other public health community facing websites related to COVID-19 mitigation such as risk reduction and prevention strategies including flu vaccines, asymptomatic spread, and contact tracing. Follow up assessments will occur at month 4 and month 7.

Interventions

The intervention consists of two planning sessions with the dyad (over 2 weeks) followed by eight topic-guided sessions delivered the RN-CHW team over 12 weeks (weekly the first 4 weeks, then bi-weekly) (Table 3). Key components of these televisits include COVID-19 risk mitigation, chronic disease management, medication adherence, family functioning/support, and community and health systems resource identification and referral with ongoing goal planning. The RN-CHW will meet weekly for progress review, follow up planning, and setting up anticipatory guidance for the next session with the dyads. The RN and CHW will also review IC or survivor dissatisfaction and other issues that require more immediate attention. RN-CHW planning will be assessed to make sure each televisit remain topic focused yet incorporates flexibility to suit the needs of each dyad.

iCINGS Fam Intervention

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • African American
  • Male and female
  • Living in a Medically Underserved Area and/or a designated rural area of South Carolina
  • ≥ 18 years and above
  • A history of a COVID-19-associated hospitalization, ER or Urgent Care visit since March 11th, 2020
  • A previous diagnosis of one or more of the following conditions: type 2 diabetes, hypertension, cardiovascular disease, chronic kidney disease, or stroke (\>3 months)
  • Male and female
  • ≥ 18 years and above
  • Must live on the same property or community, preferably within a 40-mile radius of the survivor
  • Primarily responsible for care provision and/or care/social support in the home (i.e., is not paid for services)

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University of South Carolina

Columbia, South Carolina, 29208, United States

RECRUITING

Related Publications (2)

  • Scott J, Burrison S, Barron M, Logan A, Magwood GS. Exploring Nursing Strategies to Engage Community in Cardiovascular Care. Curr Cardiol Rep. 2023 Oct;25(10):1351-1359. doi: 10.1007/s11886-023-01949-9. Epub 2023 Sep 4.

    PMID: 37665520BACKGROUND
  • Magwood GS, Ellis C Jr, Hughes Halbert C, Toussaint EA, Scott J, Nemeth LS. Exploring Barriers to Effective COVID-19 Risk Mitigation, Recovery, and Chronic Disease Self-Management: A Qualitative Multilevel Perspective. Patient Relat Outcome Meas. 2024 Sep 18;15:241-253. doi: 10.2147/PROM.S467743. eCollection 2024.

MeSH Terms

Conditions

Cardiovascular DiseasesRenal Insufficiency, ChronicDiabetes Mellitus, Type 2Chronic DiseaseStroke

Condition Hierarchy (Ancestors)

Renal InsufficiencyKidney DiseasesUrologic DiseasesFemale Urogenital DiseasesFemale Urogenital Diseases and Pregnancy ComplicationsUrogenital DiseasesMale Urogenital DiseasesDisease AttributesPathologic ProcessesPathological Conditions, Signs and SymptomsDiabetes MellitusGlucose Metabolism DisordersMetabolic DiseasesNutritional and Metabolic DiseasesEndocrine System DiseasesCerebrovascular DisordersBrain DiseasesCentral Nervous System DiseasesNervous System DiseasesVascular Diseases

Study Officials

  • Gayenell S Magwood, PhD

    University of South Carolina

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Program Coordinator

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
INVESTIGATOR, OUTCOMES ASSESSOR
Purpose
SUPPORTIVE CARE
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Professor

Study Record Dates

First Submitted

April 14, 2022

First Posted

May 11, 2022

Study Start

January 3, 2023

Primary Completion (Estimated)

May 30, 2026

Study Completion (Estimated)

June 30, 2026

Last Updated

May 16, 2025

Record last verified: 2025-05

Data Sharing

IPD Sharing
Will not share

Locations