NCT05363189

Brief Summary

Women who have their breast reconstructed with autologous tissue seem to be more satisfied with their breast. However, autologous breast reconstruction entails a bigger operation, and the usage of more health care resources, than some other methods, such as implant-based techniques. The main objectives of the present study are to investigate if pre- peri- and postoperative protocols can be safely modified, so the operation demands less resources, while maintaining a low complication rate and a high patient satisfaction.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
380

participants targeted

Target at P75+ for all trials

Timeline
5mo left

Started May 2022

Longer than P75 for all trials

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress92%
May 2022Dec 2026

First Submitted

Initial submission to the registry

May 2, 2022

Completed
Same day until next milestone

Study Start

First participant enrolled

May 2, 2022

Completed
3 days until next milestone

First Posted

Study publicly available on registry

May 5, 2022

Completed
4.7 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 31, 2026

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 31, 2026

Last Updated

July 3, 2025

Status Verified

June 1, 2025

Enrollment Period

4.7 years

First QC Date

May 2, 2022

Last Update Submit

June 30, 2025

Conditions

Keywords

breast reconstructionplastic surgerymicrosurgeryfree flap

Outcome Measures

Primary Outcomes (2)

  • Re-operations

    Any re-operations performed for any cause during the first 7 days after the operation

    7 days

  • Length of stay (LOS) in hospital

    Number of days the patient stays in the hospital after the operation

    7 days

Secondary Outcomes (3)

  • Patient reported satisfaction and quality of life

    12 months

  • Surgical corrections

    5 years

  • Costs

    5 years

Study Arms (4)

No venons augmentation

Retrospective group of patients who have not received venous augmentation during their operation.

Procedure: No venous augmentation

Venous augmentation

Retrospective group of patients who have received venous augmentation during their operation.

Procedure: Venous augmentation

ERAS protocol

Retrospective group operated according to the traditional ERAS (enhanced recovery after surgery) protocol

Procedure: Traditional ERAS (enhanced recovery after surgery) protocol

Sahlgrenska recovery protocol

Prospective group operated according to the Sahlgrenska recovery protocol.

Procedure: Sahlgrenska recovery protocol

Interventions

Increasing the venous drainage of a deep inferior epigastric artery perforator (DIEP) flap by anastomosing the superficial inferior epigastric vein to the cephalic vein

Also known as: Double venous system drainage, Cephalic vein turndown
Venous augmentation

Pre-, peri-, and post-operative care as described in the ERAS protocol

ERAS protocol

Pre-, peri-, and post-operative care as described in the Sahlgrenska recovery protocol

Sahlgrenska recovery protocol

Traditional deep inferior epigastric artery perforator flap (DIEP)

No venons augmentation

Eligibility Criteria

Age18 Years - 100 Years
Sexfemale
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Biological women undergoing breast reconstruction with a deep inferior epigastric artery perforator flap in Sahlgrenska university hospital.

You may qualify if:

  • Operated or will be operated with a DIEP flap in the department
  • \>18 years of age

You may not qualify if:

  • Inability to leave informed consent
  • Inability to understand and speak Swedish (for the questionnaire)

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Sahlgrenska university hospital

Gothenburg, 413 45, Sweden

RECRUITING

MeSH Terms

Conditions

Breast Neoplasms

Interventions

Enhanced Recovery After SurgeryClinical Protocols

Condition Hierarchy (Ancestors)

Neoplasms by SiteNeoplasmsBreast DiseasesSkin DiseasesSkin and Connective Tissue Diseases

Intervention Hierarchy (Ancestors)

Perioperative CareSurgical Procedures, OperativeTherapeuticsEpidemiologic Study CharacteristicsHealth Care Evaluation MechanismsQuality of Health CareHealth Care Quality, Access, and Evaluation

Central Study Contacts

Emma Hansson, MD, PhD

CONTACT

Study Design

Study Type
observational
Observational Model
CASE CONTROL
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER GOV
Responsible Party
SPONSOR

Study Record Dates

First Submitted

May 2, 2022

First Posted

May 5, 2022

Study Start

May 2, 2022

Primary Completion (Estimated)

December 31, 2026

Study Completion (Estimated)

December 31, 2026

Last Updated

July 3, 2025

Record last verified: 2025-06

Data Sharing

IPD Sharing
Will not share

Locations