Neurophysiological Correlates of Dissociation Induced by Virtual Reality Hypnosis.

NCT05357131 | Completed DMC

• 1 other identifier: QuDDoS - Phase-I
• Study Type: interventional
• Target: 68
• Locations: 1 country
• Sites: 1

Brief Summary

Hypnosis and virtual reality are potential tools in treating acute pain. Nevertheless, the neurophysiological correlates of such tools used together, i.e. 'virtual reality hypnosis' (VRH) (Patterson et al., 2004) remain mostly understudied. This study aims to improve our knowledge and understanding of the dissociation (i.e., a mental separation of components of behaviours that normally would be processed together) occurring during VRH. This is a randomized controlled study that will be conducted on healthy participants. As the final goal is to propose such a tool in the clinical context, a clinical application will also be carried out subsequently. Thus the principal outcome is to study dissociation in the context of VRH from a behavioral and neurophysiological point of view. Secondary objectives aim at identifying factors that influence the dissociative effect seen in VRH, as well as measuring traits of hypnotisability, absorption, immersive abilities, dissociation trait and state, pain, and anxiety levels that might impact the effectiveness of such a tool.

Conditions

Healthy Volunteers

Keywords

Virtual Reality; Hypnosis; Dissociation

Outcome Measures

Primary Outcomes (1)

• Dissociation state

  Corresponds to a dissociation between the bodily sensations and the actual environment that one feels in a particular situation. will be assessed with a numerical rating scale (0= no dissociation; 10 = dissociation from environment).

  During the procedure

Secondary Outcomes (14)

• Dissociation trait

  During the procedure

• Hypnotisability

  During the procedure

• Absorption trait

  During the procedure

• Anxiety trait

  During the procedure

• Immersion propensity (trait)

  During the procedure

Study Arms (2)

Healthy Volunteers - Hypnosis without VR (HYP )

EXPERIMENTAL

Cross-over and within-participant control design: Participants will receive recorded hypnosis without VR.

Behavioral: Hypnosis without VR (HYP)

Healthy Volunteers - Hypnosis with VR (VRH)

EXPERIMENTAL

Cross-over and within-participant control design: Participants will receive hypnosis with VR.

Device: Hypnosis with VR (VRH)

Interventions

Hypnosis without VR (HYP) BEHAVIORAL

HYP will last for 15 minutes including an induction phase of 5 minutes. The hypnotic audio script "Heaven of Peace" developped/recorded by Pr. M-E. Faymonville will be used.

Healthy Volunteers - Hypnosis without VR (HYP )

Hypnosis with VR (VRH) DEVICE

The VRH intervention will use the Aqua video session developed by Oncomfort.

Healthy Volunteers - Hypnosis with VR (VRH)

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may not qualify if:

• Low auditory and/or visual acuity precludes the use of the device.
• Head or face wounds precluding the use of the device.
• Schizophrenia, dissociative disorder or any other psychiatric disorder.
• Non-proficiency in French (Research language).
• Patient under 18 years old.
• Phobia of deep water.
• Allergy to cutaneous electrodes.
• Chronic pain and/or chronic analgesics consumption.
• Medication affecting the autonomic nervous system.
• Dizziness.

Sponsors & Collaborators

• University of Liege: lead
• Oncomfort: collaborator
• Biowin: collaborator

Study Sites (1)

CHU of Liège

Liège, 4000, Belgium

Location

MeSH Terms

Conditions

Dissociative Disorders

Interventions

Hypnosis

Condition Hierarchy (Ancestors)

Mental Disorders

Intervention Hierarchy (Ancestors)

Mind-Body Therapies; Complementary Therapies; Therapeutics; Psychotherapy; Behavioral Disciplines and Activities

Study Officials

• Audrey VANHAUDENHUYSE, PhD

  CHU of Liège

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Masking Details: Methodology of virtual reality hypnosis prevents masking the participants and the experimenter.
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: PhD, Responsible of the Sensation and Perception Research Group, in the GIGA CONSCIOUSNESS department

Model Details: Cross-over and within-participant control design.

Study Record Dates

• First Submitted: April 11, 2022
• First Posted: May 2, 2022
• Study Start: June 8, 2022
• Primary Completion: June 14, 2023
• Study Completion: June 14, 2023
• Last Updated: July 6, 2023

Record last verified: 2023-07

Data Sharing

• IPD Sharing: Will not share

Locations

BE (1)