Relationship Between Serum N/OFQ and Brain-heart Syndrome

NCT05344794 | Unknown

• 1 other identifier: hanyi20220418
• Study Type: observational
• Target: 120
• Locations: 1 country
• Sites: 1

Brief Summary

Choosing the neurology patients in the Second Hospital of Shanxi Medical University, diagnosed with patients with cerebral syndrome into the experimental group; patients who did not have cerebral syndrome included in the control group, and all selected people had no intimate relationship with each other.Specimen collecting control group and the study group serum inflammatory factor IL-6, solvent peptide and catecholamine content. The difference between the two groups of data was observed.According to the literature, it is guess: The solitary peptide content of the experimental group will be higher than the control group, and is positively correlated with IL-6, catecholamine content.The difference was statistically significant.

Conditions

Cerebral-Cardiac Syndrome

Outcome Measures

Primary Outcomes (3)

• N/OFQ

  Serum N/OFQ levels

  24 hours

• IL-6

  Serum IL-6 levels

  24 hours

• NE

  Serum NE levels

  24 hours

Study Arms (2)

CCS group

Patients with cerebral syndrome diagnosed by the Second Hospital of Shanxi Medical University

Diagnostic Test: Enzyme-linked immunosorbent assay

Control group

Patients who have not had a cerebral syndrome in ischemic stroke

Diagnostic Test: Enzyme-linked immunosorbent assay

Interventions

Enzyme-linked immunosorbent assay DIAGNOSTIC_TEST

Serum N/OFQ , IL-6 and NE levels were detected.

CCS group; Control group

Eligibility Criteria

• Age: 45 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients in the Second Hospital of Shanxi Medical University from May 2022 to October 2023

You may qualify if:

• Diagnostic criteria in compliance with cerebral syndrome
• Acute ischemic stroke patients in line with the "Chinese Acute Ischemic Stroke Treatment Guide 2018" related diagnostic criteria
• There is no intimate relationship between all selected people and knows this study, and signs informed consent

You may not qualify if:

• Heart-type cerebral infarction, hemorrhagic stroke, brain tumor and past intracranial hemorrhage
• Complicated with severe cardiovascular complications (such as coronary heart disease, acute coronary syndrome, acute myocardial infarction, chronic heart failure, atrial fibrillation, etc.)
• Complicated with severe liver and kidney dysfunction (such as coagulous dysfunction, cirrhosis, nephrotic syndrome , Renal failure, etc.)
• Complicated with severe diabetes complications (such as diabetic nephropathy, diabetic foot, diabetic acidosis, high blood sugar hypertonic state, diabetes coronary heart disease, etc.)
• Complicated with Psychological disease
• Complicated with chronic obstructive pulmonary disease(COPD)
• BMI\> 40

Sponsors & Collaborators

• Zheng Guo: lead

Study Sites (1)

Second of Shanxi Medical University

Taiyuan, Shanxi, 030001, China

RECRUITING

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Target Duration: 3 Days
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: professor

Study Record Dates

• First Submitted: April 18, 2022
• First Posted: April 25, 2022
• Study Start: May 1, 2023
• Primary Completion: September 30, 2023
• Study Completion: October 31, 2023
• Last Updated: February 21, 2023

Record last verified: 2023-02

Locations

CN (1)