Hamstring Injury (HAMIR) Index

NCT05343052 | Completed DMC

• 3 other identifiers: 2021-1420A536130Protocol Version 6/15/2023
• Study Type: observational
• Target: 699
• Locations: 1 country
• Sites: 5

Brief Summary

The investigators will combine state-of-the-art quantitative imaging, on-field biomechanics, and computational analytics into the largest-of-its-kind study to assess hamstring strain injury (HSI) risk and recovery in elite collegiate football players. The study will take place over 3 years and enroll up to 560 student athletes from Division I (D1) teams: University of Wisconsin-Madison, Brigham Young University and the University of North Carolina-Chapel Hill.

Conditions

Hamstring Injury

Keywords

football; athlete

Outcome Measures

Primary Outcomes (2)

• Aim 1: Initial Hamstring Strain Injury (HSI)

  The outcome will be occurrence of an index HSI, measured at the athlete level. Athlete characteristics will be used to develop the quantitative HAMIR index to predict those at greatest risk of HSI. This aim will also identify potential future targets for injury risk mitigation and prophylactic strategies. HSI defined as an acute injury to the posterior thigh that limits full, unrestricted sports participation and includes two or more of the following symptoms: palpable pain along the hamstring muscles, posterior thigh pain without radicular symptoms, weakness and/or pain with resisted knee flexion, and pain with running.

  up to 3 years

• Aim 2: Recurrent Hamstring Strain Injury (HSI)

  The outcome will be the occurrence of a recurrent, or secondary, HSI measured at the athlete level. The investigators will use quantification of injury metrics (e.g., volume of initial edema and volume, shape and location of long-term scar) and incorporate these into the analytics framework to develop a new "re-injury" HAMIR index. Similar to Aim 1, this aim will identify potential future targets for re-injury risk mitigation and prophylactic approaches. Re-injury will be defined as an acute HSI that occurs to either limb within 6 months of an index HSI.

  up to 3 years

Other Outcomes (8)

• Change in inertial measurement units (IMU)-based sprinting biomechanics

  baseline and within 7 days of RTS (variable time points during training and within season)

• Change in eccentric strength

  baseline and within 7 days of RTS (variable time points during training and within season)

• Change in Hamstring Outcome Score (HaOS)

  baseline

Study Arms (1)

Student Athlete

Student-athlete rostered on the varsity football team of participating institutions between 5/1/2022-6/30/2025 (study period)

Other: Patient Reported Outcomes Surveys; Other: Clinical Assessments; Other: Biomechanical and Neuromuscular Assessments; Device: Conventional MRI

Interventions

Patient Reported Outcomes Surveys OTHER

* Oslo Sports Trauma Research Center Hamstring Injury Screening Questionnaire (HaOS) at baseline * Functional Assessment Scale for Acute Hamstring Injuries (FASH) within 7 days of injury and within 7 days of return to sport (RTS)

Also known as: HaOS, FASH

Student Athlete

Clinical Assessments OTHER

* Injury History at baseline, within 7 days of injury, within 7 days of RTS * Pain and Function Assessments within 7 days of injury, within 7 days of RTS

Student Athlete

Biomechanical and Neuromuscular Assessments OTHER

* Eccentric Strength measure at baseline and within 7 days of RTS * Sprinting Biomechanics at baseline and within 7 days of RTS

Student Athlete

Conventional MRI DEVICE

at baseline, within 7 days of injury, and within 7 days of RTS

Also known as: Magnetic Resonance Imaging (MRI)

Student Athlete

Eligibility Criteria

• Age: 18 Years - 26 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Student-athlete rostered on the varsity football team of participating institutions between 5/1/2022-6/30/2025 (study period)

You may qualify if:

• Student-athlete rostered on the varsity football team of participating institutions between 5/1/2022-6/30/2025 (study period)

You may not qualify if:

• History of malignant disease
• Contraindication to MRI

Sponsors & Collaborators

• University of Wisconsin, Madison: lead
• National Football League: collaborator

Study Sites (5)

Indiana University

Bloomington, Indiana, 47405, United States

Location

Notre Dame University

Notre Dame, Indiana, 46556, United States

Location

University of North Carolina - Chapel Hill

Chapel Hill, North Carolina, 27514, United States

Location

Brigham Young University

Provo, Utah, 84602, United States

Location

University of Wisconsin - Madison

Madison, Wisconsin, 53705, United States

Location

Related Publications (1)

• Heiderscheit BC, Blemker SS, Opar D, Stiffler-Joachim MR, Bedi A, Hart J, Mortensen B, Kliethermes SA; HAMIR Study Group. The development of a HAMstring InjuRy (HAMIR) index to mitigate injury risk through innovative imaging, biomechanics, and data analytics: protocol for an observational cohort study. BMC Sports Sci Med Rehabil. 2022 Jul 15;14(1):128. doi: 10.1186/s13102-022-00520-3.

  PMID: 35841053 DERIVED

MeSH Terms

Interventions

Magnetic Resonance Imaging

Intervention Hierarchy (Ancestors)

Tomography; Diagnostic Imaging; Diagnostic Techniques and Procedures; Diagnosis

Study Officials

• Bryan Heiderscheit, PT, PhD, FAPTA

  UW School of Medicine and Public Health

  PRINCIPAL INVESTIGATOR

• David Opar, PhD

  Australian Catholic University

  PRINCIPAL INVESTIGATOR

• Silvia Blemker, PhD

  Springbok Analytics

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 15, 2022
• First Posted: April 25, 2022
• Study Start: April 25, 2022
• Primary Completion: June 5, 2025
• Study Completion: June 5, 2025
• Last Updated: June 11, 2025

Record last verified: 2025-06

Data Sharing

• IPD Sharing: Will not share

Locations

US (5)