NCT05343026

Brief Summary

Considering the extent to which HAs play a role in sound perception and residual hearing preservation among patients with tinnitus and co-existing HL remains a lack of compelling extensive evidence, investigators designed this single-blind, 6-months randomized, controlled trial with two parallel groups. One is the HA treatment group, and the other is the waiting list control (WLC) group which receives no interventions during this period.

Trial Health

35
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
62

participants targeted

Target at P50-P75 for not_applicable

Timeline
Completed

Started Jul 2022

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

April 18, 2022

Completed
7 days until next milestone

First Posted

Study publicly available on registry

April 25, 2022

Completed
2 months until next milestone

Study Start

First participant enrolled

July 1, 2022

Completed
1 year until next milestone

Primary Completion

Last participant's last visit for primary outcome

July 1, 2023

Completed
5 months until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2023

Completed
Last Updated

April 25, 2022

Status Verified

April 1, 2022

Enrollment Period

1 year

First QC Date

April 18, 2022

Last Update Submit

April 21, 2022

Conditions

Outcome Measures

Primary Outcomes (2)

  • tinnitus handicap inventory (THI)

    The THI is a self-administered test, including 25 questions with grades four categories of tinnitus severity: slight corresponding to a score of 0-16, mild (18-36), moderate (38-56), severe (58-100). The higher the score the more severe the tinnitus.

    3 months from baseline

  • tinnitus handicap inventory (THI)

    The THI is a self-administered test, including 25 questions with grades four categories of tinnitus severity: slight corresponding to a score of 0-16, mild (18-36), moderate (38-56), severe (58-100). The higher the score the more severe the tinnitus.

    6 months from baseline

Secondary Outcomes (10)

  • speech recognition score (SRS) test

    3 months from baseline

  • speech recognition score (SRS) test

    6 months from baseline

  • pure tone audiometry (PTA)

    3 months from baseline

  • pure tone audiometry (PTA)

    6 months from baseline

  • otoacoustic emission (OAE)

    3 months from baseline

  • +5 more secondary outcomes

Study Arms (2)

HA treatment group

EXPERIMENTAL

Participants in the treatment group are required to wear the HAs for at least 3 hours per day, with 24 days per month. Additionally, they will receive regular counseling and lifestyle education from their physicians.

Device: Hearing aids

non-HA treatment group

NO INTERVENTION

Non-HA treatment group is a waiting list control group (WLC) in which participants will receive the intervention after the waiting period has passed. They will only receive regular counseling and lifestyle education from their physicians in this waiting period.

Interventions

As for screening the hearing and tinnitus testing, the measure typically comprises PTA, SRS, DPOAE, and several widely accepted standardized tinnitus questionnaires, including the THI for tinnitus severity and VAS for tinnitus loudness.

HA treatment group

Eligibility Criteria

Age18 Years - 70 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Adults aged older than 18 years old and less than 70 years;
  • Chronic (\>6 months) subjective tinnitus, unilateral or bilateral;
  • Diagnosed with a high-frequency SNHL;
  • Be available for six months after starting the study to complete the follow-up questionnaires;
  • Readiness to participate in the study and sign the informed consent.
  • Be covered by public health insurance and eligible for reimbursement.

You may not qualify if:

  • Objective tinnitus;
  • Conductive HL;
  • Unstable medical history that limits participation;
  • Undergoing any other concurrent treatments on tinnitus or HL;
  • Having used HAs in the past 1 year;
  • Unwilling or unable to use HAs daily;
  • Alcohol or drug abuse;
  • Unable to read or write.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Related Publications (1)

  • Li P, Tang D, Wu Y, Yin Y, Sun S. Efficacy of hearing aid treatment on sound perception and residual hearing preservation in patients with tinnitus and coexisting hearing loss: study protocol for a randomized controlled trial. Trials. 2022 Dec 27;23(1):1049. doi: 10.1186/s13063-022-07014-0.

MeSH Terms

Conditions

TinnitusHearing Loss, High-Frequency

Interventions

Hearing Aids

Condition Hierarchy (Ancestors)

Hearing DisordersEar DiseasesOtorhinolaryngologic DiseasesSensation DisordersNeurologic ManifestationsNervous System DiseasesSigns and SymptomsPathological Conditions, Signs and SymptomsHearing Loss

Intervention Hierarchy (Ancestors)

Wearable Electronic DevicesElectrical Equipment and SuppliesEquipment and SuppliesSensory Aids

Study Officials

  • Shan Sun

    Eye and ENT Hospital of Fudan University

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
INVESTIGATOR, OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

April 18, 2022

First Posted

April 25, 2022

Study Start

July 1, 2022

Primary Completion

July 1, 2023

Study Completion

December 1, 2023

Last Updated

April 25, 2022

Record last verified: 2022-04

Data Sharing

IPD Sharing
Will not share