Mechanical Cardiopulmonary Resuscitation During Treatment of Acute Respiratory Failure Through Extracorporeal Membrane Oxygenation.

NCT05342363 | Completed

• 1 other identifier: CPR during VV-ECMO
• Study Type: observational
• Target: 117
• Locations: 1 country
• Sites: 1

Brief Summary

In-hospital cardiovascular arrest is associated with poor outcome despite prompt treatment and optimal on-site resources. The population of patients treated by venovenous extracorporeal membrane oxygenation (vv-ECMO) due to pulmonary failure is a very challenging group of patients. To date, the frequency, causes and outcome of cardiovascular arrest in these patients have not been studied. We are aiming to conduct a retrospective observational study of all vv-ECMO patients treated at our ARDS centre.

Conditions

Cardiovascular Resuscitation; Venovenous Extracorporeal Membrane Oxygenation

Outcome Measures

Primary Outcomes (1)

• Survival of mechanical cardiovascular resuscitation

  Survival of mechanical cardiovascular resuscitation

  During the intensive care stay ( usually between 2 and 8 weeks)

Secondary Outcomes (2)

• Incidence of cardiovascular resuscitation i

  During the observation period 2019-2022

• Complications of resuscitation treatments

  During the intensive care stay ( usually between 2 and 8 weeks)

Study Arms (2)

cardiopulmonary resuscitation during treatment with extracorporeal membrane oxygenation

Patients treated with venovenous extracorporeal membrane oxygenation (vv-ECMO) for acute respiratory distress syndrome (ARDS) during the retrospective observation period who required mechanical cardiovascular resuscitation (CPR) during their treatment.

Treatment with extracorporeal membrane oxygenation without resuscitation

Patients treated with venovenous extracorporeal membrane oxygenation (vv-ECMO) for acute respiratory distress syndrome (ARDS) without the need for cardiovascular resuscitation during the retrospective observation period.

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients treated with veno-venous extracorporeal membrane oxygenation (vv-ECMO) for respiratory failure in acute respiratory distress syndrome (ARDS). And in addition required mechanical cardiovascular resuscitation treatment during existing therapy with veno-venous extracorporeal membrane oxygenation (vv-ECMO).

You may qualify if:

• Patients treated with veno-venous extracorporeal membrane oxygenation (vv-ECMO) due to respiratory failure during acute respiratory distress syndrome (ARDS).

You may not qualify if:

• Patients treated with veno-arterial extracorporeal membrane oxygenation (va-ECMO)

Sponsors & Collaborators

• Goethe University: lead

Study Sites (1)

University Hospital Frankfurt

Frankfurt am Main, Hesse, 60590, Germany

Location

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Physician

Study Record Dates

• First Submitted: April 16, 2022
• First Posted: April 22, 2022
• Study Start: June 1, 2022
• Primary Completion: May 1, 2023
• Study Completion: August 1, 2023
• Last Updated: August 29, 2023

Record last verified: 2023-08

Data Sharing

• IPD Sharing: Will not share

Locations

DE (1)