Trials Sponsors Conditions Drugs Pricing

Conditions

Recurrent Pregnancy Loss, Not Pregnant

Outcome Measures

Primary Outcomes (5)

Frequency of sRPL patients with microchimeric male cells
Prevalence of sRPL patients with microchimeric male cells in the peripheral blood
Non-pregnant state, performed during study completion, i.e. within 1 year
Frequency of sRPL patients with microchimeric cell originating from older brother
Determination of microchimeric cell origin: brother, son, daughter or not identified
Non-pregnant state, performed during study completion, i.e. within 1 year
Frequency of sRPL patients with microchimeric cell originating from the patient's son
Determination of microchimeric cell origin: brother, son, daughter or not identified
Non-pregnant state, performed during study completion, i.e. within 1 year
Frequency of sRPL patients with microchimeric cell originating from the patient's daughter
Determination of microchimeric cell origin: brother, son, daughter or not identified
Non-pregnant state, performed during study completion, i.e. within 1 year
Frequency of sRPL patients with microchimeric cell originating from unknown person
Determination of microchimeric cell origin: brother, son, daughter or not identified
Non-pregnant state, performed during study completion, i.e. within 1 year

Study Arms (2)

sRPL patient

EXPERIMENTAL

sRPL with an older brother and at least one child prior to diagnosis

Genetic: Blood sample

Brother or child to the sRPL patient

EXPERIMENTAL

An older brother (with at least same biological mother) og child to the sRPL patient

Genetic: Swap test

Interventions

Blood sampleGenetic

Blood sample of 12 ml EDTA plasma.

sRPL patient

Swap testGenetic

receive swab tests for collecting cells from the oral mucosa

Brother or child to the sRPL patient

Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.

Eligibility Criteria

Sexall(Gender-based eligibility)

Gender Eligibility DetailssRPL patient: women. Sibling: Older brother to sRPL patient. Child: The sRPL patient's child(ren) of both sexes. Biological sex is used.

Healthy VolunteersNo

Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

≥3 consecutive pregnancy losses ≤12 weeks of gestation, which do not include confirmed ectopic or molar pregnancies.

Sponsors & Collaborators

Odense University Hospital
Othercollaborator
Caroline Nørgaard-Pedersen
Otherlead
Aalborg University Hospital

Study Sites (1)

Aalborg University Hospital

Aalborg, 9000, Denmark

MeSH Terms

Interventions

Blood Specimen Collection

Intervention Hierarchy (Ancestors)

Specimen HandlingClinical Laboratory TechniquesDiagnostic Techniques and ProceduresDiagnosisPuncturesSurgical Procedures, OperativeInvestigative Techniques

Study Officials

Caroline Nørgaard-Pedersen, MD
Aalborg University Hospital
PRINCIPAL INVESTIGATOR

Enrollment

32 participants (actual enrollment reported by the registry).

Study Design

Study Type: interventional
Phase: not applicable
Allocation: NON RANDOMIZED
Masking: NONE
Purpose: BASIC SCIENCE
Intervention Model: PARALLEL
Sponsor Type: OTHER
Responsible Party: SPONSOR INVESTIGATOR
PI Title: Principal investigator

Study Record Dates

First Submitted

April 8, 2022

First Posted

April 22, 2022

Study Start

April 1, 2022

Actual (reported)

Microchimerism in Patients With Recurrent Pregnancy Losses

Brief Summary

Registry Overview

Trial Relationships

Study Timeline

Study Start

First Submitted

First Posted

Primary Completion

Study Completion

Conditions

Outcome Measures

Primary Outcomes (5)

Study Arms (2)

sRPL patient

Brother or child to the sRPL patient

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

MeSH Terms

Interventions

Intervention Hierarchy (Ancestors)

Study Officials

Enrollment

Study Design

Study Record Dates

You may not qualify if:

Source record

Locations

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

Study Start

First Submitted

First Posted

Primary Completion

Study Completion

Conditions

Outcome Measures

Primary Outcomes (5)

Study Arms (2)

sRPL patient

Brother or child to the sRPL patient

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

MeSH Terms

Interventions

Intervention Hierarchy (Ancestors)

Study Officials

Enrollment

Study Design

Study Record Dates

You may not qualify if:

Source record

Locations