Gamification and Medication Adherence (GAME Adherence)
Gamification and Social Incentives to Augment Medication Adherence
Gamification and Social Incentives to Augment Medication Adherence
Sponsor study identifier
interventional
43
1 country
1
Study Start
September 12, 2022
Actual (reported)Primary Completion
January 31, 2024
Actual (reported)Study Completion
July 1, 2026
Actual (reported)A two-arm randomized controlled trial to evaluate whether a gamification intervention plus involvement of a supportive partner (social support) and sending reports to physicians (accountability) increases medication adherence in patients with hypertension and hyperlipidemia. The study will randomize 84 patients with hypertension, hyperlipidemia, and a history of poor medication adherence seen in a single Penn Medicine clinic to an 18-week gamification intervention or to attention control text messages alone.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
July 1, 2026
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
March 21, 2022
Actual (reported)April 13, 2022
Actual (reported)September 12, 2022
Actual (reported)January 31, 2024
Actual (reported)July 1, 2026
Actual (reported)patient-reported adherence
Patient reported adherence will be defined as days taking all prescribed antihypertensive medications and statins divided by total days in the study over the entire study duration; this will be compared between study arms
18 weeks
Change in blood pressure over study duration
18 weeks
Patient-reported adherence in weeks 14-18
5 weeks (during study weeks 14-18)
Medication possession ratio over study duration
18 weeks
Medication possession ratio in weeks 14-18
5 weeks (during study weeks 14-18)
Change in low density lipoprotein cholesterol
18 weeks
Via the Way to Health platform, all participants will receive daily text messages asking about medication adherence for that day and twice weekly text messages asking if participants have measured blood pressure on that day.
Via the Way to Health platform, all patients will receive daily text messages asking about medication adherence for that day and twice weekly text messages asking if participants have measured blood pressure on that day. Participants are entered into a game. Each week they receive 90 points. If they took their medications or checked their blood pressure the prior day, they keep their points, but if not, they lose 10 points. At the end of the week if they have at least 70 points they move up a level, but if not, they drop a level. Participants start in the middle of 5 levels. Participants choose a support partner. At the start of the intervention, the study team holds a 3-way phone call with the participant and support partner to discuss ways they can help the participant meet their goal. The support partner gets a weekly email with the participant's progress. Primary care physicians will receive a monthly email noting patients' self-reported adherence and blood pressure.
Via the Way to Health platform, all patients will receive daily text messages asking about medication adherence for that day and twice weekly text messages asking if participants have measured blood pressure on that day. Participants are entered into a game. Each week they receive 90 points. If they took their medications or checked their blood pressure the prior day, they keep their points, but if not, they lose 10 points. At the end of the week if they have at least 70 points they move up a level, but if not, they drop a level. Participants start in the middle of 5 levels. Participants choose a support partner. At the start of the intervention, the study team holds a 3-way phone call with the participant and support partner to discuss ways they can help the participant meet their goal. The support partner gets a weekly email with the participant's progress. Primary care physicians will receive a monthly email noting patients' self-reported adherence and blood pressure.
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
University of Pennsylvania
Philadelphia, Pennsylvania, 19104, United States
Fanaroff AC, Clark K, Reid-Bey L, Rareshide C, Zhu J, Norton L, Volpp KG. A pilot randomized clinical trial of gamification to increase medication adherence. Am Heart J. 2026 Jul;297:107419. doi: 10.1016/j.ahj.2026.107419. Epub 2026 Mar 7.
Alexander Fanaroff, MD, MHS
University of Pennsylvania
43 participants (actual enrollment reported by the registry).
First Submitted
March 21, 2022
First Posted
April 13, 2022
Study Start
September 12, 2022
Actual (reported)Contact the study team to confirm eligibility.
Primary Completion
January 31, 2024
Actual (reported)Study Completion
July 1, 2026
Actual (reported)Last Updated
September 2, 2026
Record last verified: 2026-08
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Source: ClinicalTrials.gov.
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