Defining an Immunological Signature Related to Lesion Location in Multiple Sclerosis

NCT05326048 | Completed

• 1 other identifier: 35RC21_3030_APOLLO
• Study Type: observational
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

The objective of APOLLO is therefore to identify biomarkers associated with the CNS involvement phenotype in early MS patients.

Conditions

Multiple Sclerosis

Outcome Measures

Primary Outcomes (1)

• Differences in Immune profile

  Comparison of immune profile by CyTOF between two groups of MS patients: "brain" versus "brain + ME" CITRUS algorithm will be used to perform a unsupervised hierarchical clustering of cells processed by cytof and SAM test to assess statistical differences in abundances or marker expression levels between groups of patients

  1 day

Interventions

cytof analysis OTHER

cytof analysis of biological samples of CIS patients. Genomic analysis

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

CIS patients

You may qualify if:

• Patients with clinically isolated syndrome (CIS) participating in the OFSEP cohort (French MS Observatory)
• At least 18 years old
• Diagnosed with MS according to the 2017 criteria at the time of their last visit
• Not opposed to participating in the study
• Had at least one visit in the year following sampling
• Followed up for at least 1 year after collection.
• Signed OFSEP consent form

You may not qualify if:

• CIS patients with progressive MS

Sponsors & Collaborators

• Rennes University Hospital: lead

Study Sites (1)

University hospital of Rennes

Rennes, 35000, France

Location

MeSH Terms

Conditions

Multiple Sclerosis

Condition Hierarchy (Ancestors)

Demyelinating Autoimmune Diseases, CNS; Autoimmune Diseases of the Nervous System; Nervous System Diseases; Demyelinating Diseases; Autoimmune Diseases; Immune System Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 9, 2022
• First Posted: April 13, 2022
• Study Start: March 9, 2022
• Primary Completion: September 9, 2022
• Study Completion: September 9, 2022
• Last Updated: March 29, 2023

Record last verified: 2023-03

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)