Ventricular Fibrillation Following Out-of-hospital Cardiac Arrest

NCT05325385 | Unknown

• 1 other identifier: IRAS Project ID: 315145
• Study Type: observational
• Target: 15,000
• Locations: 1 country
• Sites: 1

Brief Summary

The majority of survivors suffering an out-of-hospital cardiac arrest (OHCA) are those who initially present with a shockable rhythm, which is usually ventricular fibrillation (VF). When untreated, VF progresses to asystole over a short period of time so the percentage of those with a survivable rhythm also decreases with time. There is relatively little data exploring the initial rate of VF and the time course of its subsequent progression to a non-shockable rhythm. An understanding of this data will give a better picture of how potentially survivable rhythms (VF) change with time and guide the response times that are required to ensure arrival before VF deteriorates to asystole. The Investigators will use the UK OHCA outcomes database to examine the percentage of patients presenting with VF as the initial rhythm according to time since collapse in order to establish the rate at which VF deteriorates to asystole.

Conditions

Cardiac Arrest, Out-Of-Hospital; Ventricular Fibrillation

Keywords

Cardiac arrest; Ventricular fibrillation; Ambulance; Survival

Outcome Measures

Primary Outcomes (1)

• Presenting rhythm

  An estimate of the incidence of VF at the initial time of collapse from a out-of-hospital cardiac arrest.

  From 01.01.2016 to 31.12.2020

Study Arms (1)

OHCA attended by ambulance service

All adults attended by ambulance service where time of collapse and initial rhythm is known.

Other: There are no interventions - this is a database study only

Interventions

There are no interventions - this is a database study only OTHER

There are no interventions - this is a database study only

OHCA attended by ambulance service

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All patients in cardiac arrest attended by ambulance services (England) where data has been submitted to the Warwick University OHCA outcomes database.

You may qualify if:

• Adult
• Out-of-hospital cardiac arrest
• Known time of collapse
• Known initial rhythm documented by ambulance crew

You may not qualify if:

• Paediatric cases
• Trauma

Sponsors & Collaborators

• University Hospital Southampton NHS Foundation Trust: lead
• Warwick University Clinical Trials Unit: collaborator

Study Sites (1)

University Hospital Southampton

Southampton, Hampshire, SO16 6YD, United Kingdom

Location

Related Links

• Warwick University OHCA outcomes database

MeSH Terms

Conditions

Out-of-Hospital Cardiac Arrest; Ventricular Fibrillation; Heart Arrest

Condition Hierarchy (Ancestors)

Heart Diseases; Cardiovascular Diseases; Arrhythmias, Cardiac; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Central Study Contacts

Charles Deakin, MD

CONTACT

02380777222; charles.deakin@nhs.net

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: OTHER
• Target Duration: 1 Day
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 5, 2022
• First Posted: April 13, 2022
• Study Start: September 1, 2022
• Primary Completion: January 1, 2023
• Study Completion: May 1, 2023
• Last Updated: April 27, 2022

Record last verified: 2022-04

Data Sharing

• IPD Sharing: Will not share

Locations

GB (1)