Comparison Between LDCT With DL Recontruction and Standard Dose CT
Comparison of Low Dose Contrast Enhanced Abdominal CT With Deep Learning Reconstruction With Standard Dose CT With Iterative Reconstruction in Patients With Suspected Liver Metastases: A Prospective Multicenter Study
1 other identifier
observational
134
1 country
2
Brief Summary
This prospective study aims to perform intra-individual comparison of the image quality between low dose liver CT with deep learning reconstruction and standard dose liver CT with iterative reconstruction in patients with liver metastasis.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Jun 2022
Typical duration for all trials
2 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
April 4, 2022
CompletedFirst Posted
Study publicly available on registry
April 12, 2022
CompletedStudy Start
First participant enrolled
June 2, 2022
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 30, 2023
CompletedStudy Completion
Last participant's last visit for all outcomes
June 30, 2024
CompletedAugust 18, 2023
August 1, 2023
1.6 years
April 4, 2022
August 16, 2023
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
liver lesion conspicuity
graded on a five-point scale (1-5) with higher score indicates a better conscpicuity.
6 months after the CT scan
Secondary Outcomes (1)
liver lesion detectability
6 months after the CT scan
Study Arms (1)
Liver metastasis
Patients with suspicion of liver metastasis and scheduled for CT
Interventions
contrast-enhanced abdomen CT using dual-source CT scanner using A-tube (67% radiation) and B-tube (33% radiation). * full dose CT data (A +B tubes, 100%) are reconstructed with iterative reconstruction (conventional) * low dose CT data (A-tube only, B-tube only) are reconstructed with deep learning commercially available software. * images are reconstructed using full dose (A- \& B- tubes) and smaller dose (A-tube only, B-tube only)
Eligibility Criteria
Patients who are referred to Radiology department for undergoing contrast-enhanced abdomen CT.
You may qualify if:
- patients with underlying malignancy and suspicion of liver metastasis
- patients with known liver metastasis and on follow-up
- AND scheduled for contrast enhanced abdomen CT
- signed informed consent
You may not qualify if:
- absolute or relative contra-indication for contrast-enhanced CT
- diffuse infiltrative liver lesion or multiple (\> 10) metastases
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (2)
Seoul National University Hospital
Seoul, South Korea
Ulsan University Hospital
Ulsan, 44033, South Korea
Related Publications (1)
Lee TY, Yoon JH, Park JY, Park SH, Kim H, Lee CM, Choi Y, Lee JM. Intraindividual Comparison of Image Quality Between Low-Dose and Ultra-Low-Dose Abdominal CT With Deep Learning Reconstruction and Standard-Dose Abdominal CT Using Dual-Split Scan. Invest Radiol. 2025 Jul 1;60(7):454-462. doi: 10.1097/RLI.0000000000001151. Epub 2025 Jan 28.
PMID: 39874436DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Jeong Min Lee, MD
Seoul National University Hospital
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Professor
Study Record Dates
First Submitted
April 4, 2022
First Posted
April 12, 2022
Study Start
June 2, 2022
Primary Completion
December 30, 2023
Study Completion
June 30, 2024
Last Updated
August 18, 2023
Record last verified: 2023-08
Data Sharing
- IPD Sharing
- Will not share