Brief Summary

Evaluation of the ability of the Palpator to detect hidden (occult) lung tumours that cannot be visualized or palpated using the traditional methods of visual inspection, grasper palpation, and VATS ultrasound.

Trial Health

35
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
22

participants targeted

Target at below P25 for not_applicable lung-cancer

Timeline
Completed

Started Mar 2024

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

February 23, 2022

Completed
2 months until next milestone

First Posted

Study publicly available on registry

April 11, 2022

Completed
1.9 years until next milestone

Study Start

First participant enrolled

March 1, 2024

Completed
1.8 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 15, 2025

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 15, 2025

Completed
Last Updated

October 25, 2023

Status Verified

October 1, 2023

Enrollment Period

1.8 years

First QC Date

February 23, 2022

Last Update Submit

October 23, 2023

Conditions

Keywords

PalpationTactile image sensorLung ultrasoundVATS procedures

Outcome Measures

Primary Outcomes (1)

  • Tumour detection

    The palpator will be declared feasible of it can detect at least 80% of tumours (sensitivity) without the need for a thoracotomy.

    1 day

Secondary Outcomes (2)

  • Prevention of thoracotomy

    1 day

  • Adverse events

    30 days

Study Arms (1)

Study arm

OTHER

All patients will undergo a standard VATS pleuroscopy to visually search for the nodule and its position. Sequential assessment using a grasper, the Palpator, the VATS ultrasound probe, and then finger palpation will be done to detect the nodule.

Device: PalpatorDevice: GrasperDevice: UltrasoundOther: Finger palpation

Interventions

PalpatorDEVICE

Palpator for tumor localization

Study arm
GrasperDEVICE

Atraumatic lung grasper

Study arm

VATS ultrasound

Study arm

Palpation of the lung/tumour using the surgeon's finger

Study arm

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Age \> 18 years
  • Peripheral occult sub-pleural (\>5 mm) solitary lung nodule \< 50 mm on CT scan scheduled for surgical removal using a VATS approach

You may not qualify if:

  • Semi-solid nodules (ground glass nodule).
  • Pregnancy or potentially pregnant women.
  • Mentally challenged.
  • Inability to consent for the study.
  • Patients less than 18 years old.
  • Patients with pulmonary nodules easily located during VATS (\> 50 mm, pleural puckering, invading chest wall)
  • Patients who have chest anatomy precluding VATS resection.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

MeSH Terms

Conditions

Lung NeoplasmsThoracic Neoplasms

Interventions

Ultrasonography

Condition Hierarchy (Ancestors)

Respiratory Tract NeoplasmsNeoplasms by SiteNeoplasmsLung DiseasesRespiratory Tract Diseases

Intervention Hierarchy (Ancestors)

Diagnostic ImagingDiagnostic Techniques and ProceduresDiagnosis

Central Study Contacts

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Purpose
DIAGNOSTIC
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Chair Chief Thoracic Surgery

Study Record Dates

First Submitted

February 23, 2022

First Posted

April 11, 2022

Study Start

March 1, 2024

Primary Completion

December 15, 2025

Study Completion

December 15, 2025

Last Updated

October 25, 2023

Record last verified: 2023-10

Data Sharing

IPD Sharing
Will not share

no plan