Nutritional and Metabolic Management of Toxidermia Patients Requiring Intensive Care (TEN Metabolism)

NCT05320653 | Completed

• 1 other identifier: CER-2018-2268
• Study Type: observational
• Target: 35
• Locations: 0 countries
• Sites: N/A

Brief Summary

Retrospective observational cohort study including all patients admitted for toxidermia (Lyell syndrome, Stevens-Johnson Syndrome (SJS), or other extensive skin destruction) to the Burn unit of the adult ICU of the Lausanne burn center between 2006 and 2020. Inclusion criteria: age \>18 years and admission to the burn-ICU for toxidermia whatever body surface affected. Exclusion criteria: to have declined access to the medical record, a stay shorter than 24 hours, and major burns. The observation period will be limited to the first 31 days of the ICU stay. All variables related to nutritional and metabolic management will be recorded

Conditions

Stevens-Johnson Syndrome Toxic Epidermal Necrolysis Spectrum

Keywords

Critical care; Metabolism; Nutrition; Protein

Outcome Measures

Primary Outcomes (1)

• Compliance with ICU feeding protocol

  Proportion of ICU days with covered needs

  ICU stay, but maximum 30 days

Secondary Outcomes (2)

• Protein delivery

  ICU stay but maximum 30 days

• Energy delivery

  ICU stay but maximum 30 days

Interventions

Medical nutrition DIETARY_SUPPLEMENT

Nutrition therapy of the critically ill patients

Also known as: enteral, oral and parenteral nutrition

Eligibility Criteria

• Age: 16 Years+
• Sex: all
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Cohort of all patients admitted for SJS/TEN and other toxidermia

You may qualify if:

• age \>18 years
• admission to the burn-ICU

You may not qualify if:

• declined access to the medical record
• stay shorter than 24hours

Sponsors & Collaborators

• Centre Hospitalier Universitaire Vaudois: lead

Related Publications (1)

• Karakus M, Pantet O, Charriere M, Favre D, Gaide O, Berger MM. Nutritional and metabolic characteristics of critically ill patients admitted for severe toxidermia. Clin Nutr. 2023 Jun;42(6):859-868. doi: 10.1016/j.clnu.2023.04.006. Epub 2023 Apr 8.

  PMID: 37086614 DERIVED

MeSH Terms

Conditions

Stevens-Johnson Syndrome

Interventions

Nutrition Therapy; Parenteral Nutrition

Condition Hierarchy (Ancestors)

Stomatitis; Mouth Diseases; Stomatognathic Diseases; Drug Eruptions; Dermatitis; Skin Diseases; Skin and Connective Tissue Diseases; Erythema Multiforme; Erythema; Skin Diseases, Vesiculobullous; Hypersensitivity, Delayed; Hypersensitivity; Immune System Diseases; Drug Hypersensitivity; Drug-Related Side Effects and Adverse Reactions; Chemically-Induced Disorders

Intervention Hierarchy (Ancestors)

Therapeutics; Feeding Methods; Nutritional Support

Study Officials

• Eckert Philippe, MD

  Université de Lausanne, Director of the ICU

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 31 Days
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Prof.Hon.

Study Record Dates

• First Submitted: April 2, 2022
• First Posted: April 11, 2022
• Study Start: January 1, 2006
• Primary Completion: December 31, 2020
• Study Completion: May 31, 2022
• Last Updated: August 5, 2022

Record last verified: 2022-08

Data Sharing

• IPD Sharing: Will not share