Substance Use and Eating Disorders : Food Craving and Addiction Transfer

NCT05315635 | Completed

• 1 other identifier: 2022-A00126-37
• Study Type: observational
• Target: 294
• Locations: 1 country
• Sites: 1

Brief Summary

Substance Use Disorder (SUD) and Eating Disorders (ED) are severe and persistent disturbances that are associated with significant harm. These two disorders have many clinical similarities, including craving and behavioral loss of control. Recently, craving for food has been described in newly abstinent patients with SUD. the aim of the study is to verify the hypothesis of addiction transfer based on common neurobiological mechanisms between substance craving and food craving, that postulates that food craving would correspond to an attempt to regulate substance craving (or vice versa).

Conditions

Substance Use Disorders; Eating Disorders

Keywords

Substance Use Disorders; Eating Disorders; Food craving; Addiction transfer; Addiction; Craving

Outcome Measures

Primary Outcomes (3)

• Craving for substance

  Measurement of craving for substances by Visual Analogue Scale (VAS) - from 0 (no desire at all) to 10 (very much in demand) / higher scores mean a worse outcome

  At the inclusion

• Craving for substance

  Measurement of craving for substances by Visual Analogue Scale (VAS) - from 0 (no desire at all) to 10 (very much in demand) / higher scores mean a worse outcome

  At week-3

• Craving for food

  Measurement of food craving by Food Cravings Questionnaire-Trait-Reduced (FCQ-Tr) - from NEVER to ALLWAYS / higher scores mean a worse or better outcome, depending of the question

  At the inclusion

Secondary Outcomes (11)

• Identify common determinants of food craving in patients suffering from ED

  At inclusion

• Identify common determinants of food craving in patients suffering from ED & SUD - Addictive characteristics :

  At inclusion

• Identify common determinants of food craving in patients suffering from ED & SUD - Emotional characteristics

  At inclusion

• Identify common determinants of food craving in patients suffering from ED & SUD - Psychopathological and cognitive characteristics

  At inclusion

• Identify Medical characteristics : of food craving in patients suffering from ED - Medical characteristics :

  At inclusion

Study Arms (1)

Epidemiology

Inpatients who initiate treatment for a substance use disorder (SUD) will have to complete self-questionnaires, a clinical psychiatric assessment (MINI) and a cognitive assessment (MoCA). These participants will be assessed at admission in addiction unit and at discharge, 3 weeks after withdrawal. Outpatients who begin treatment for an eating disorder (ED) will have to complete self-questionnaires and a clinical psychiatric assessment (MINI) at the beginning of the outpatient treatment program

Other: Questionnaire

Interventions

Questionnaire OTHER

Patients treated for substance use disorders and patients treated for eating disorders will have to complete self-questionnaires and a clinical psychiatric (MINI) at the inclusion. Patients suffering from substance use disorder will be assessed 3 weeks after inclusion. Questionnaires are : * Modified Yale Food Addiction (mYFAS 2.0) and Impulsive Behavior Scale (UPPS-P) * Trait Meta-Mood Scale (TMMS), Hospital Anxiety and Depression Scale (HADs), Emotional Appetite Questionnaire (EMAQ), Perceived Stress Scale (PSS-10), Multidimensional Assessment of Interoceptive Awareness (MAIA) and Five Facet Mindfulness Questionnaire (FFMQ) * Mini International Neuropsychiatric Interview (MINI), Eating Disorder Examination-Questionnaire (EDE-Q), Rosenberg's Self Esteem (RSE) and Ruminative Response Scale for Eating disorders (RRS-ED) * Pittsburgh Sleep Quality Index (PSQI) and Montreal Cognitive Assessment (MoCA)

Epidemiology

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Diagnostic and Statistical Manual (DSM)-5 diagnostic criteria for substance use disorder/behavioral addiction (gambling) or DSM-5 diagnostic criteria for eating disorders (Anorexia nervosa, Bulimia nervosa, Hyperphagia access)

You may qualify if:

• DSM-5 diagnostic criteria for substance use disorder/behavioral addiction (gambling) or an eating disorder (Anorexia nervosa, Bulimia nervosa or Hyperphagia access).
• Begin treatment in addiction complex care unit, located in inter-hospital unit Charles Perrens Hospital and Bordeaux University Hospital
• Non-opposition formulated

You may not qualify if:

• Severely impaired physical and/or mental health that, according to the investigator, may affect the participant's compliance with the study and understanding of assessment tools
• Trouble in understanding/writing French
• Hospitalization for less than 3-weeks for patients with substance use disorders or behavioral addiction (gambling)
• Be under guardianship
• Pregnant and/or lactating woman

Sponsors & Collaborators

• Centre Hospitalier Charles Perrens, Bordeaux: lead

Study Sites (1)

Centre Hospitalier Universitaire de Bordeaux

Bordeaux, Gironde, 33000, France

Location

Related Publications (5)

• Atkinson TJ. Central and peripheral neuroendocrine peptides and signalling in appetite regulation: considerations for obesity pharmacotherapy. Obes Rev. 2008 Mar;9(2):108-20. doi: 10.1111/j.1467-789X.2007.00412.x.

  PMID: 18257752 RESULT

• Avena NM, Murray S, Gold MS. Comparing the effects of food restriction and overeating on brain reward systems. Exp Gerontol. 2013 Oct;48(10):1062-7. doi: 10.1016/j.exger.2013.03.006. Epub 2013 Mar 25.

  PMID: 23535488 RESULT

• Bydlowski S, Corcos M, Jeammet P, Paterniti S, Berthoz S, Laurier C, Chambry J, Consoli SM. Emotion-processing deficits in eating disorders. Int J Eat Disord. 2005 May;37(4):321-9. doi: 10.1002/eat.20132.

  PMID: 15856501 RESULT

• Calero-Elvira A, Krug I, Davis K, Lopez C, Fernandez-Aranda F, Treasure J. Meta-analysis on drugs in people with eating disorders. Eur Eat Disord Rev. 2009 Jul;17(4):243-59. doi: 10.1002/erv.936.

  PMID: 19475697 RESULT

• Canan F, Karaca S, Sogucak S, Gecici O, Kuloglu M. Eating disorders and food addiction in men with heroin use disorder: a controlled study. Eat Weight Disord. 2017 Jun;22(2):249-257. doi: 10.1007/s40519-017-0378-9. Epub 2017 Apr 22.

  PMID: 28434177 RESULT

MeSH Terms

Conditions

Substance-Related Disorders; Feeding and Eating Disorders; Behavior, Addictive

Interventions

Surveys and Questionnaires

Condition Hierarchy (Ancestors)

Chemically-Induced Disorders; Mental Disorders; Signs and Symptoms, Digestive; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Compulsive Behavior; Impulsive Behavior; Behavior

Intervention Hierarchy (Ancestors)

Data Collection; Epidemiologic Methods; Investigative Techniques; Health Care Evaluation Mechanisms; Quality of Health Care; Health Care Quality, Access, and Evaluation; Public Health; Environment and Public Health

Study Officials

• Mélina FATSEAS, Prof, MD

  Physician

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 4, 2022
• First Posted: April 7, 2022
• Study Start: April 1, 2022
• Primary Completion: March 1, 2024
• Study Completion: April 1, 2024
• Last Updated: June 18, 2024

Record last verified: 2024-06

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)