Neural Mobilization for Reduction of Spasticity in Stroke

NCT05314465 | Completed DMC

• 2 other identifiers: MMDU/IEC/1935U1111-1276-6515
• Study Type: interventional
• Target: 7
• Locations: 1 country
• Sites: 3

Brief Summary

Spasticity after stroke is common that affect upper limb strength and make activities of daily living difficult. There are many techniques but not any standardized technique for long term effect on reduction of spasticity and improving upper limb strength. This study aimed to explore and understand the effectiveness of neural mobilization on reduction of spasticity and improving upper limb strength in individuals with stroke. This is mixed method approach of embedded design, multicentric study recruited 7 individuals with stroke as no new themes or codes were emerging (data saturated). Median nerve mobilization was given 20 oscillations per minute for 3 times \& repeated 3 times with a pause of 1 minute between each sets for 5times/week for 4weeks. Outcome measures were Modified Ashworth Scale (MAS), Brunnstrom's grading of hand recovery and Hydraulic hand dynamometer(HHD) for grip and pinch strength. Pre and post outcomes data were collected at baseline and 4weeks after intervention and in depth face to face structured interviews was conducted after 4weeks of intervention to explore the effectiveness of median nerve mobilization on reduction of spasticity and the improvement of upper limb strength.

Conditions

Stroke

Keywords

Stroke, spasticity, neural mobilization, Upper limb

Outcome Measures

Primary Outcomes (1)

• Modified Ashworth Scale (MAS)

  For spasticity, Total 4 grades are there. Grade 0 means no increase in muscle tone and grade 4 means affected part rigid in flexion or extension. More grade means more spasticity is there.

  Change from baseline and 4 weeks

Secondary Outcomes (2)

• Brunnstrom's stages for hand recovery

  Change from baseline and 4 weeks

• Hydraulic hand dynamometer

  Change from baseline and 4 weeks

Study Arms (1)

Median nerve mobilization

EXPERIMENTAL

Experimental arm given Median nerve mobilization for 12mins 3sets for 3mins each with 1 minute interval in between for 5times a week for 4weeks

Other: Median nerve mobilization

Interventions

Median nerve mobilization OTHER

Median nerve mobilization was given 20 oscillations per minute for 3 times \& repeated 3 times with a pause of 1 minute between each sets for 5times/week for 4weeks.

Median nerve mobilization

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Participants with subacute and chronic stroke (1month and above) having upper limb spasticity.
• Participants with haemorrhagic and ischemic stroke.
• Participants who tolerate the supine position.
• Participants who are oriented and alert.
• Both males and females.
• Participants older than 18 years.

You may not qualify if:

• Participants with a score greater than 3 on The Modified Ashworth Scale.
• Participants with affected speech.
• Participants with upper limb deformity.
• Participants experiencing dizziness.
• Any increase in the dosage of anti-spastic medications during the intervention period.
• General health problems or pathologies that affect the nervous system like uncontrolled diabetes, hypertension and recent surgeries.
• Recent onset of worsening neurological signs.

Sponsors & Collaborators

• Asir John Samuel: lead

Study Sites (3)

Maharishi Markandeshwar Institute of Physiotherapy & Rehabilitation

Ambāla, Haryana, 133207, India

Location

Healing Hands Physiotherapy & Rehabilitation

Hisar, Haryana, 125001, India

Location

Bedi Hospital

Kaithal, Haryana, 136027, India

Location

MeSH Terms

Conditions

Stroke; Muscle Spasticity

Condition Hierarchy (Ancestors)

Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases; Muscular Diseases; Musculoskeletal Diseases; Muscle Hypertonia; Neuromuscular Manifestations; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Rittu Sharma, (MPT)

  Maharishi Markandeshwar Institute of Physiotherapy and Rehabilitation

  PRINCIPAL INVESTIGATOR

• Asir John Samuel, Ph.D

  Maharishi Markandeshwar Institute of Physiotherapy and Rehabilitation

  STUDY CHAIR

• Akanksha Saxena, (Ph.D)

  Maharishi Markandeshwar Institute of Physiotherapy and Rehabilitation

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: March 30, 2022
• First Posted: April 6, 2022
• Study Start: November 22, 2021
• Primary Completion: February 19, 2022
• Study Completion: March 15, 2022
• Last Updated: August 17, 2022

Record last verified: 2022-08

Locations

IN (3)