Examining Sex-based Differences in Metabolic and Mechanistic Responses to Disuse Induced Muscle Atrophy
1 other identifier
interventional
24
1 country
1
Brief Summary
The purpose of the proposed research is to define whether there are differences between females and males (i.e. sex-based differences) in the metabolic and mechanistic regulation of disuse-induced muscle atrophy in vivo in humans.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started Nov 2022
Typical duration for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
March 30, 2022
CompletedFirst Posted
Study publicly available on registry
April 6, 2022
CompletedStudy Start
First participant enrolled
November 1, 2022
CompletedPrimary Completion
Last participant's last visit for primary outcome
November 15, 2024
CompletedStudy Completion
Last participant's last visit for all outcomes
November 15, 2024
CompletedNovember 25, 2024
November 1, 2024
2 years
March 30, 2022
November 21, 2024
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Fractional muscle protein synthesis rate
Integrative fractional muscle protein synthesis rates in the immobilized and non-immobilized leg
Integrative fractional muscle protein synthesis rates over 7 days
Secondary Outcomes (4)
Muscle size
Baseline and 7 days
Muscle strength
Baseline and 7 days
mRNA expression
Baseline and 7 days
Protein abundance and phosphorylation
Baseline and 7 days
Study Arms (2)
Single Leg Immobilization - Males
EXPERIMENTALMales will be subjected to 7-days of single-leg immobilization.
Single Leg Immobilization - Females
EXPERIMENTALFemales will be subjected to 7-days of single-leg immobilization.
Interventions
7-days of single leg immobilization to induce muscle atrophy
Eligibility Criteria
You may qualify if:
- Aged between 18-35 years inclusive
- Healthy, recreationally active (active for \>5 hours/ week)
- Having given informed consent
You may not qualify if:
- Type I or Type II diabetes
- Highly trained (active for \> 15 hours/week)
- Lower limb and/or back injuries in the last 6 months
- A history of thrombosis / cardiovascular disease
- Use of anticoagulants
- Musculoskeletal / orthopedic disorders
- Use of tobacco products
- Using medications known to modulate skeletal muscle metabolism including corticosteroids, hormone replacement therapy (HRT), non-steroidal anti-inflammatory drugs (i.e. paracetamol) and over-the-counter supplements including protein powder, creatine monohydrate, and fish oil
- Pregnant
- Currently participating in another clinical trial/ physical intervention research study
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Currie Gynasium 309 - McGill University
Montreal, Quebec, H2W 1S4, Canada
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NON RANDOMIZED
- Masking
- SINGLE
- Who Masked
- OUTCOMES ASSESSOR
- Purpose
- BASIC SCIENCE
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Principal Investigator
Study Record Dates
First Submitted
March 30, 2022
First Posted
April 6, 2022
Study Start
November 1, 2022
Primary Completion
November 15, 2024
Study Completion
November 15, 2024
Last Updated
November 25, 2024
Record last verified: 2024-11
Data Sharing
- IPD Sharing
- Will not share