NCT05314387

Brief Summary

Post-market, prospective, non randomized, open label, multicentre, clinical study analysing outcomes of shoulder arthroplasty with SMR TT Hybrid Glenoid with or without SMR Cementless Finned Short Stem

Trial Health

65
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
100

participants targeted

Target at P50-P75 for all trials

Timeline
35mo left

Started Apr 2022

Longer than P75 for all trials

Status
not yet recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress59%
Apr 2022Apr 2029

First Submitted

Initial submission to the registry

March 18, 2022

Completed
14 days until next milestone

Study Start

First participant enrolled

April 1, 2022

Completed
5 days until next milestone

First Posted

Study publicly available on registry

April 6, 2022

Completed
5 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

April 1, 2027

Expected
2 years until next milestone

Study Completion

Last participant's last visit for all outcomes

April 1, 2029

Last Updated

April 6, 2022

Status Verified

March 1, 2022

Enrollment Period

5 years

First QC Date

March 18, 2022

Last Update Submit

March 29, 2022

Conditions

Keywords

Shoulder JointShoulder ReplacementArthritis with rotator cuff tearPost traumatic fracture sequele

Outcome Measures

Primary Outcomes (1)

  • Proportion of patients reaching a clinical progression from baseline to 24-month follow-up

    The primary endpoint consists of the proportion of patients reaching a clinical progression from baseline to 24-month follow-up measured as: * Constant score improvement of greater than 10; * Adjusted Constant score greater than or equal to 54.

    24 Months

Secondary Outcomes (11)

  • Measure American Shoulder and Elbow Surgeons Shoulder Score (ASES)

    Baseline to 24 and 60 Months

  • Measure Oxford shoulder score

    Baseline to 24 and 60 Months

  • Measure Constant Score

    Baseline to 24 and 60 Months

  • Measure Simple Shoulder Test

    Baseline to 24 and 60 Months

  • Measure Patient Satisfaction

    Baseline to 24 and 60 Months

  • +6 more secondary outcomes

Study Arms (2)

SMR TT Hybrid Glenoid without Cementless Finned Short Stem

Patients implanted with SMR TT Hybrid Glenoid without Cementless Finned Short Stem

Device: SMR TT Hybrid Glenoid without Cementless Finned Short Stem

SMR TT Hybrid Glenoid with Cementless Finned Short Stem

Patients implanted with SMR TT Hybrid Glenoid with Cementless Finned Short Stem

Device: SMR TT Hybrid Glenoid with Cementless Finned Short Stem

Interventions

The subject SMR Hybrid Glenoid System and SMR cementless finned short stem is intended for both primary or revision anatomic and reverse shoulder joint replacement. The glenoid components when used as part of an anatomic shoulder replacement are intended for cemented fixation.

SMR TT Hybrid Glenoid without Cementless Finned Short Stem

The subject SMR Hybrid Glenoid System and SMR cementless finned short stem is intended for both primary or revision anatomic and reverse shoulder joint replacement. The glenoid components when used as part of an anatomic shoulder replacement are intended for cemented fixation. The fins are intended to enhance press-fit fixation. The same proximal morse taper is used for coupling to the same humeral bodies in the SMR Shoulder System. The SMR finned short stem is intended for cementless fixation.

SMR TT Hybrid Glenoid with Cementless Finned Short Stem

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Orthopedic Clinics

You may qualify if:

  • Both genders;
  • Age ≥ 18 years old;
  • Full skeletal maturity;
  • Life expectancy over 5 years;
  • Patient is requiring primary unilateral arthroplasty based on physical examination and medical history;
  • Good bone quality evaluated by the Investigator and the intraoperative evaluation;
  • A diagnosis in the target shoulder of one or more of the S-11 SMR TT Hybrid Glenoid and Cementless Finned Short Stem Version Sep 2021 2.0 Confidential Page11 following:
  • Primary osteoarthritis;
  • Secondary osteoarthritis;
  • Post-traumatic arthritis;
  • Rheumatoid arthritis;
  • Avascular necrosis
  • acute fractures of the humeral head that cannot be treated with other fracture fixation methods;
  • cuff tear arthropathy (only in combination with CTA Heads);
  • Glenoid arthrosis without excessive glenoid bone loss: A1, A2 and B1 according to Walch classification.

You may not qualify if:

  • Patient requiring revision shoulder arthroplasty;
  • Osteoporosis with a history of non-traumatic fractures;
  • Steroid injections within the previous 3 months;
  • Contralateral shoulder replacement within the previous 3 months;
  • Significant proven or suspicious infection of the target shoulder or any serious infectious disease before the study according to the Investigator;
  • Significant neurological or musculoskeletal disorders that may compromise functional recovery;
  • Not recovered axillary nerve palsy;
  • Non functioning deltoid muscle;
  • Known or suspicious hypersensitivity to the metal or other components and materials of the implant;
  • Participation in any experimental drug/device study within the 6 months prior to the preoperative visit;
  • Women of childbearing potential who are pregnant, nursing, or planning to become pregnant.
  • These are key eligibility criteria, other eligibility criteria apply.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

MeSH Terms

Conditions

OsteoarthritisArthritis, RheumatoidOsteonecrosisHumeral FracturesRotator Cuff Tear Arthropathy

Condition Hierarchy (Ancestors)

ArthritisJoint DiseasesMusculoskeletal DiseasesRheumatic DiseasesConnective Tissue DiseasesSkin and Connective Tissue DiseasesAutoimmune DiseasesImmune System DiseasesBone DiseasesNecrosisPathologic ProcessesPathological Conditions, Signs and SymptomsArm InjuriesWounds and InjuriesFractures, BoneChondrocalcinosisCrystal Arthropathies

Central Study Contacts

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

March 18, 2022

First Posted

April 6, 2022

Study Start

April 1, 2022

Primary Completion (Estimated)

April 1, 2027

Study Completion (Estimated)

April 1, 2029

Last Updated

April 6, 2022

Record last verified: 2022-03

Data Sharing

IPD Sharing
Will not share