NCT05312450

Brief Summary

This is a prospective cohort study that takes place in a clinic of Hangzhou, China. The aim of this study is to explore the molecular mechanism of special Chinese medicine formula combined with personalized nutrition to assist the treatment of diabetes from the aspect of multi-omics view. This study also aims to explore the relationship between gut microbiome and blood glucose in the process of personalized diet intervention.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
515

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Mar 2022

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

December 2, 2021

Completed
3 months until next milestone

Study Start

First participant enrolled

March 10, 2022

Completed
26 days until next milestone

First Posted

Study publicly available on registry

April 5, 2022

Completed
1.2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 1, 2023

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

June 1, 2023

Completed
Last Updated

June 13, 2025

Status Verified

May 1, 2025

Enrollment Period

1.2 years

First QC Date

December 2, 2021

Last Update Submit

June 10, 2025

Conditions

Keywords

DiabetesNutritionGut microbiomeMetabolomicsTraditional Chinese medicine

Outcome Measures

Primary Outcomes (6)

  • gut microbiome

    Fecal microbiome will be analyzed by metagenome sequencing

    Baseline

  • gut microbiome

    Fecal microbiome will be analyzed by metagenome sequencing

    The first week

  • gut microbiome

    Fecal microbiome will be analyzed by metagenome sequencing

    The first month

  • gut microbiome

    Fecal microbiome will be analyzed by metagenome sequencing

    The second month

  • gut microbiome

    Fecal microbiome will be analyzed by metagenome sequencing

    The third month

  • The change of postprandial blood glucose

    Fingertip blood glucose was used to detect postprandial blood glucose. The change of postprandial blood glucose among the three months will be measured

    Up to three months

Secondary Outcomes (10)

  • Fecal metabolomics

    Baseline

  • Fecal metabolomics

    The first week

  • Fecal metabolomics

    The first month

  • Fecal metabolomics

    The second month

  • Fecal metabolomics

    The third month

  • +5 more secondary outcomes

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Diabetes who are volunteer to participate and sign the informed consent form, and without special diseases, such as mental system diseases or other cognitive impairment, cancer and other malignant wasting diseases.

You may qualify if:

  • Comply with the diagnosis of diabetes in western medicine and the diagnostic criteria of type 2 diabetes in the "Guiding Principles for Clinical Research of New Chinese Medicines"; volunteer to participate and sign the informed consent form.

You may not qualify if:

  • Major special diseases, such as mental system diseases or other cognitive impairment, cancer and other malignant wasting diseases.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Westlake University

Hangzhou, Zhejiang, 310024, China

Location

Biospecimen

Retention: SAMPLES WITH DNA

Biospecimen including fecal, saliva, fasting boold, and fasting urine samples will be collected

MeSH Terms

Conditions

Diabetes Mellitus

Condition Hierarchy (Ancestors)

Glucose Metabolism DisordersMetabolic DiseasesNutritional and Metabolic DiseasesEndocrine System Diseases

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

December 2, 2021

First Posted

April 5, 2022

Study Start

March 10, 2022

Primary Completion

June 1, 2023

Study Completion

June 1, 2023

Last Updated

June 13, 2025

Record last verified: 2025-05

Locations