Neurologic Physiology After Removal of Therapy (NeuPaRT)
NeuPaRT
1 other identifier
observational
158
1 country
5
Brief Summary
The purpose of this study is to determine when brain function stops compared to when the heart stops by monitoring electrical brain activity in patients who are taken off life support and progress to death in the intensive care unit.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Oct 2022
Longer than P75 for all trials
5 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
March 23, 2022
CompletedFirst Posted
Study publicly available on registry
April 1, 2022
CompletedStudy Start
First participant enrolled
October 18, 2022
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 1, 2027
ExpectedStudy Completion
Last participant's last visit for all outcomes
March 1, 2027
January 30, 2026
January 1, 2026
4.4 years
March 23, 2022
January 28, 2026
Conditions
Outcome Measures
Primary Outcomes (1)
Patient Accrual complete study procedures)
90 patients at all sites and an additional 18 patients at the lead site for specific tests
2022 to 2023
Secondary Outcomes (2)
Waveform Data Completeness
2022-2023
Time Difference Circulatory Arrest and Cessation of EEG Activity
2022-2023
Interventions
1. brain cortical activity using full scalp 2. cerebral blood flow velocity 3. during the dying process following planned withdrawal of life sustaining measures (WLSM)
Eligibility Criteria
The study will include all patients admitted to a participating ICU who fulfil all the inclusion criteria and for whom none of the exclusion criteria exist.
You may qualify if:
- Age ≥ 18 years
- Plan for the withdrawal of life sustaining measures (WLSM)
- Attending physician anticipates patient will die within 24 hours of the withdrawal of life sustaining measures
- Patient has an indwelling arterial cannula for monitoring blood pressure
You may not qualify if:
- Brain death or plan for Neurologic Determination of Death (NDD)
- Injuries that anatomically preclude the use of neurologic monitoring
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (5)
University of Calgary Foothills Campus
Calgary, Alberta, T2N1N4, Canada
Kingston Health Sciences Centre
Kingston, Ontario, K7L2V7, Canada
London Health Sciences Centre
London, Ontario, N6A 5A5, Canada
Ottawa Hospital
Ottawa, Ontario, K1H8L6, Canada
Centre hospitalier de l'Université de Montréal,
Montreal, Quebec, H2X3E4, Canada
Related Publications (1)
Gofton T, Dhanani S, Meade M, Boyd JG, Chamberlain E, Chandler J, Chasse M, Scales NB, Choi YH, D'Aragon F, Debicki D, English S, Fantaneanu TA, Kramer AH, Kromm J, Murphy N, Norton L, Singh J, Smith MJ, Weijer C, Shemie S, Bentall TC, Campbell E, Slessarev M. Neurologic Physiology after Removal of Therapy (NeuPaRT) study: study protocol of a multicentre, prospective, observational, pilot feasibility study of neurophysiology after withdrawal of life-sustaining measures. BMJ Open. 2023 Apr 27;13(4):e073643. doi: 10.1136/bmjopen-2023-073643.
PMID: 37105694DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Teneille Gofton, MD MSc FRCPC
London Health Sciences Centre
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
March 23, 2022
First Posted
April 1, 2022
Study Start
October 18, 2022
Primary Completion (Estimated)
March 1, 2027
Study Completion (Estimated)
March 1, 2027
Last Updated
January 30, 2026
Record last verified: 2026-01
Data Sharing
- IPD Sharing
- Will share
- Shared Documents
- STUDY PROTOCOL, SAP
- Time Frame
- After completion of data analysis (5 years after study initiation August 2022)
Requests for data sharing should be directed to the principal investigator (Dr. T. Gofton) and will be considered on a case by case basis and with approval from the Western Health Sciences Research Ethics Board. No video will be shared at any time.