Circulating Tumor Cell Detection in Hepatocellular Carcinoma

NCT05297955 | Completed

• 1 other identifier: TJ-IRB20211242
• Study Type: observational
• Target: 458
• Locations: 1 country
• Sites: 1

Brief Summary

The investigators examined circulating tumor cells (CTC) in the perioperative peripheral blood of hundreds of HCC patients undergoing liver cancer surgery using CellSearch technology between 2013 and 2016. Although the investigators have done a preliminary study of the above data and published some results, the previous study was only a basic analysis. Now the investigators plan to carry out further in-depth analysis of these data, including hospitalization data, follow-up results, surgical tumors and blood specimens, and make full use of biostatistics, molecular biology, pathology and other related techniques to elucidate the association between the levels of CTC or CTC clusters and patients' disease during the perioperative period, and to explore the molecular basis of CTC production in hepatocellular carcinoma.

Conditions

Circulating Tumor Cell

Outcome Measures

Primary Outcomes (1)

• Data analysis of relationship between CTC and pathological indicators of hepatocellular carcinoma

  The previous CTC detection data of 458 cases was collected. To compare the relationship between CTC level of perioperative peripheral blood and clinical indexes of HCC patients, the main statistical analysis were one-way ANOVA, Student's T test and Multivariable Cox regression.

  2022.03.15

Study Arms (2)

The number of CTC in HCC patient great than or equal to two

According to the cutoff of CTC, the number of CTC in HCC patient great than or equal to two

The number of CTC in HCC patient less than two

According to the cutoff of CTC,the number of CTC in HCC patient less than two

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Perioperative patients with hepatocellular carcinoma who underwent CTC detection of peripheral blood

You may qualify if:

• The pathological diagnosis was primary liver cancer.
• Undergoing radical surgical treatment
• No preoperative antitumor therapy was received
• Between 18 and 80 years old

You may not qualify if:

• With distal metastasis
• With other tumors
• Perioperative death
• Recurrence within one month after surgery
• Lost contact before the first follow-up

Sponsors & Collaborators

• Tongji Hospital: lead

Study Sites (1)

Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology

Wuhan, Hubei, 430030, China

Location

Biospecimen

Retention: SAMPLES WITH DNA

blood

MeSH Terms

Conditions

Neoplastic Cells, Circulating

Condition Hierarchy (Ancestors)

Neoplasm Metastasis; Neoplastic Processes; Neoplasms; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Xiaoping Chen

  Tongji Hospital

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Chair of surgery department

Study Record Dates

• First Submitted: March 17, 2022
• First Posted: March 28, 2022
• Study Start: November 1, 2013
• Primary Completion: June 30, 2016
• Study Completion: March 15, 2022
• Last Updated: April 6, 2022

Record last verified: 2022-03

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)