Green Light Exposure in Healthy Volunteers Exposure in Normal Human Volunteers
Investigating the Analgesic Effects of Green Light Exposure in Normal Human Volunteers
1 other identifier
interventional
30
1 country
1
Brief Summary
This research project is intended to understand the mechanisms of action for the pain-relieving properties of visual green light exposure. The investigators have shown previously that greenlight exposure decreased acute and chronic pain in both animals and humans. However, the investigators do not yet understand how green light exposure is capable of such function.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable chronic-pain
Started Jun 2022
Longer than P75 for not_applicable chronic-pain
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
February 22, 2022
CompletedFirst Posted
Study publicly available on registry
March 25, 2022
CompletedStudy Start
First participant enrolled
June 14, 2022
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 31, 2026
ExpectedStudy Completion
Last participant's last visit for all outcomes
December 31, 2026
January 5, 2026
December 1, 2025
4.6 years
February 22, 2022
December 29, 2025
Conditions
Outcome Measures
Primary Outcomes (2)
Ascending Pain Pathway
Changes in activity of the ascending pain pathway
Two hours
Descending Pain Pathway
Changes in activity of the descending pain pathway
Two hours
Secondary Outcomes (5)
Delta Brain Activities
Two hours
Theta Brain Activities
Two hours
Alpha Brain Activities
Two hours
Sigma Brain Activities
Two hours
Beta Brain Activities
Two hours
Study Arms (2)
Green Light Exposure
ACTIVE COMPARATORSubjects will complete thermal and mechanical pain threshold detection tests and Electroencephalography (EEG). After completion, subjects will be exposed to a green light-emitting diode for two hours. After exposure, thermal and mechanical pain threshold assessments and Electroencephalography (EEG) will be conducted.
White Light Exposure
PLACEBO COMPARATORSubjects will complete thermal and mechanical pain threshold detection tests and Electroencephalography (EEG). After completion, subjects will be exposed to a white light-emitting diode for two hours. After exposure, thermal and mechanical pain threshold assessments and Electroencephalography (EEG) will be conducted.
Interventions
Eligibility Criteria
You may qualify if:
- years healthy men or women
- Able to speak and understand English
- No history of Chronic pain
- No known neuropathies in areas that testing will take place, (forearms, muscle at the base of thumb on the palm of the hand and upper back/shoulder area.
You may not qualify if:
- Serious mental illness defined as distortions of perception, delusions, hallucinations, and unusual behaviors resulting in loss of contact with reality. This will be assessed during the screening interview.
- Colorblindness or uncorrected cataracts.
- Tissue damage in areas that testing will take place, (forearms, muscle at the base of the thumb on the palm of the hand, and upper back/should area.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Banner University Medical Center Tucson
Tucson, Arizona, 85724, United States
Related Publications (1)
Ibrahim MM, Patwardhan A, Gilbraith KB, Moutal A, Yang X, Chew LA, Largent-Milnes T, Malan TP, Vanderah TW, Porreca F, Khanna R. Long-lasting antinociceptive effects of green light in acute and chronic pain in rats. Pain. 2017 Feb;158(2):347-360. doi: 10.1097/j.pain.0000000000000767.
PMID: 28092651RESULT
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Mohab Ibrahim, PhD, MD.
University of Arizona
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- BASIC SCIENCE
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Associate Professor, Anesthesiology
Study Record Dates
First Submitted
February 22, 2022
First Posted
March 25, 2022
Study Start
June 14, 2022
Primary Completion (Estimated)
December 31, 2026
Study Completion (Estimated)
December 31, 2026
Last Updated
January 5, 2026
Record last verified: 2025-12
Data Sharing
- IPD Sharing
- Will not share