Cognitive Impact in Patients With COVID-19 Infection

NCT05293561 | Completed DMC

• 1 other identifier: WGEK-NCG
• Study Type: observational
• Target: 120
• Locations: 1 country
• Sites: 1

Brief Summary

SARS-COV-2 (severe acute respiratory syndrome- corona virus - 2) infection reframed medical knowledge in many aspects, yet there is still a lot to be discovered. Coronavirus disease 19 (COVID-19) can cause neuropsychiatric, psychological and psychosocial impairments. Literature regarding cognitive impact of COVID-19 is still limited. Objective: evaluation of cognitive function, anxiety and depression among patients with Coronavirus disease 19.

Conditions

Cognitive Impairment; COVID-19 Respiratory Infection

Keywords

COVID-19; Cognitive Impairment; Anxiety; Depression

Outcome Measures

Primary Outcomes (1)

• Cognitive impairment

  degree of affection in cognition due to COVID-19 infection

  1 month

Secondary Outcomes (1)

• Level of Anxiety and depression among COVID-19 cases

  1 month

Study Arms (2)

COVID-19 cases

O2 saturation readings, Mini-mental state examination (MMSE), Hamilton's anxiety (HAM-A) Hamilton's depression rating scales (HAM-D)

control

O2 saturation readings, Mini-mental state examination (MMSE), Hamilton's anxiety (HAM-A) Hamilton's depression rating scales (HAM-D)

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

COVID-19 patients diagnosed using Real Time-Polymerase Chain Reaction to confirm the diagnosis and healthy control belonging to either gender. COVID-19 patients recruited from home isolation at first visit in outpatient clinic and then after end of isolation period for 14 days, patients included from hospital isolation ward; also recruited from the respiratory isolation ICU, chest department of Assiut university hospital.

You may qualify if:

• COVID-19 patients diagnosed using Real Time-Polymerase Chain Reaction to confirm the diagnosis

You may not qualify if:

• neurological disorders, psychological disorders, dementia, Alzheimer's disease, end-organ failure conditions

Sponsors & Collaborators

• Assiut University: lead

Study Sites (1)

Assiut University

Asyut, 711111, Egypt

Location

Related Publications (2)

• Alemanno F, Houdayer E, Parma A, Spina A, Del Forno A, Scatolini A, Angelone S, Brugliera L, Tettamanti A, Beretta L, Iannaccone S. COVID-19 cognitive deficits after respiratory assistance in the subacute phase: A COVID-rehabilitation unit experience. PLoS One. 2021 Feb 8;16(2):e0246590. doi: 10.1371/journal.pone.0246590. eCollection 2021.

  PMID: 33556127 BACKGROUND

• Germani A, Buratta L, Delvecchio E, Gizzi G, Mazzeschi C. Anxiety Severity, Perceived Risk of COVID-19 and Individual Functioning in Emerging Adults Facing the Pandemic. Front Psychol. 2020 Dec 7;11:567505. doi: 10.3389/fpsyg.2020.567505. eCollection 2020.

  PMID: 33364996 BACKGROUND

MeSH Terms

Conditions

Cognitive Dysfunction; COVID-19; Anxiety Disorders; Depression

Condition Hierarchy (Ancestors)

Cognition Disorders; Neurocognitive Disorders; Mental Disorders; Pneumonia, Viral; Pneumonia; Respiratory Tract Infections; Infections; Virus Diseases; Coronavirus Infections; Coronaviridae Infections; Nidovirales Infections; RNA Virus Infections; Lung Diseases; Respiratory Tract Diseases; Behavioral Symptoms; Behavior

Study Officials

• Waleed Gamal elddin, MD

  Assiut university hospitals

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Lecturer of Chest diseases and tuberculosis

Study Record Dates

• First Submitted: March 22, 2022
• First Posted: March 24, 2022
• Study Start: June 1, 2021
• Primary Completion: October 1, 2022
• Study Completion: December 1, 2022
• Last Updated: January 31, 2024

Record last verified: 2024-01

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)