NCT05285007

Brief Summary

The purpose of this graduate student research study is to investigate the relationship between limited ankle dorsiflexion and the potential effects on a single limb squat task in the Patellofemoral/Knee Pain population.

Trial Health

57
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
60

participants targeted

Target at P25-P50 for not_applicable

Timeline
Completed

Started Mar 2022

Longer than P75 for not_applicable

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

March 2, 2022

Completed
6 days until next milestone

First Submitted

Initial submission to the registry

March 8, 2022

Completed
9 days until next milestone

First Posted

Study publicly available on registry

March 17, 2022

Completed
4.1 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 1, 2026

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

May 1, 2026

Completed
Last Updated

February 4, 2026

Status Verified

February 1, 2026

Enrollment Period

4.2 years

First QC Date

March 8, 2022

Last Update Submit

February 2, 2026

Conditions

Outcome Measures

Primary Outcomes (1)

  • Weight bearing lunge test

    This test is used to assess a participant's available dorsiflexion range of motion in a weight bearing position. Furthermore, this places the participants hip, knee, and ankle into a flexed position which correlates with the squat tests we will be using.

    change between baseline and post intervention on Day 1

Secondary Outcomes (1)

  • Patellofemoral Disability Index

    change between baseline and post intervention on Day 1

Study Arms (2)

Primary Intervention Group

EXPERIMENTAL

The experimental group will receive two interventions to increase dorsiflexion range of motion.

Other: Mobilization with Movement

Minimal Intervention Group

ACTIVE COMPARATOR

The minimal intervention group will read and infographic and complete 5 minutes of treadmill walking.

Other: No mobilization with movement and education

Interventions

Participants ankle will not be taped and they will walk on the treadmill for 5 minutes and receive education.

Minimal Intervention Group

Participants will be lunging on a box with posterior ankle glide of 10 seconds times 5 sets. They will have 30 seconds rest between trials. Participant will have their ankle taped and then walk on a treadmill at a self-selected pace for 5 minutes.

Primary Intervention Group

Eligibility Criteria

Age18 Years - 59 Years
Sexfemale(Gender-based eligibility)
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • History of active Patellofemoral Pain for at least 6 months
  • No clinic based therapeutic interventions for a 6-month period prior to testing
  • Females aged 18-59 years' old
  • Limited ankle dorsiflexion as noted by \<45degs using the weight bearing lunge test

You may not qualify if:

  • History of musculoskeletal surgery or fractures on the tested leg or lumbar spine that could affect their biomechanics during the study
  • History of soft tissue or skeletal abnormalities in the tested limb
  • Current knee effusion
  • Resting pain greater than 5/10

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Loma Linda University

Loma Linda, California, 92350, United States

RECRUITING

MeSH Terms

Conditions

Patellofemoral Pain Syndrome

Interventions

MovementEducational Status

Condition Hierarchy (Ancestors)

Joint DiseasesMusculoskeletal Diseases

Intervention Hierarchy (Ancestors)

Physiological PhenomenaMusculoskeletal Physiological PhenomenaMusculoskeletal and Neural Physiological PhenomenaSocioeconomic FactorsPopulation Characteristics

Study Officials

  • Everett Lohman, Dsc

    Loma Linda University

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Everett Lohman, DSc

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
PARTICIPANT
Purpose
OTHER
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

March 8, 2022

First Posted

March 17, 2022

Study Start

March 2, 2022

Primary Completion

May 1, 2026

Study Completion

May 1, 2026

Last Updated

February 4, 2026

Record last verified: 2026-02

Locations