Pulmonary and Extrapulmonary Impacts of COVID-19 on Young Adults

NCT05282043 | Completed

• 1 other identifier: PEPICov
• Study Type: interventional
• Target: 68
• Locations: 1 country
• Sites: 1

Brief Summary

When the literature search is conducted, it is seen that there are many studies examining the effects of COVID-19 disease on individuals in various disease groups (MS, stroke, Parkinson, COPD, asthma, etc.) and age groups (adult, geriatric, etc.). However, it has been determined that there is no study examining the impacts of this disease on functional capacity, physical activity, pulmonary function, emotional state, sleep, and quality of life in healthy young adults. This study will reveal whether COVID-19 disease causes an effect on the mentioned parameters in young adults. The aim of recent study is to investigate functional capacity, respiration, pain, depression, sleep and quality of life in young adults post COVID-19. For this purpose, participants' upper extremity and lower extremity muscle strength, 6-minute walking distance, O2 saturation, posture evaluation, spirometric evaluation, pain threshold, pain intensity, dyspnea, and leg fatigue measurements will be recorded. In addition to these measurements, general fatigue, quality of life, depression, physical activity level, sleep quality parameters will be evaluated and the data obtained will be analyzed with appropriate statistical methods. The goals of recent work,

• To determine whether COVID-19 disease causes a decrease in functional capacity and changes in respiratory parameters in young adults, as well as to determine whether there are effects such as pain, depression, decreased sleep and quality of life,
• To determine whether there are significant changes in the values of the relevant outcome measurements in all the mentioned parameters,
• As a result of these, to determine the effects of COVID-19 disease on these parameters in young adults with objective, measurable data and to guide researchers and clinicians who do/will conduct studies on the subject.

Conditions

Post COVID-19

Keywords

COVID-19; respiration; physical capacity; sleep; muscle strength; 6-minute walking test

Outcome Measures

Primary Outcomes (1)

• 6-minute walk test

  unit: meters

  up to 6 months

Secondary Outcomes (13)

• magnitude of muscle strength of upper and lower extremity

  up to 6 months

• value of O2 saturation

  up to 6 months

• Corbin's postural assessment

  up to 6 months

• spirometer testing

  up to 6 months

• pressure pain threshold

  up to 6 months

Other Outcomes (1)

• The post-COVID-19 functional status (PCFS) scale

  up to 6 months

Study Arms (2)

post COVID-19 group

EXPERIMENTAL

In this group cases, who were infected with COVID-19 and had at least 12 weeks after diagnosis, will be allocated. Those should have no symptoms of COVID-19 such as fever, cough, ageusia, anosmia, diarrhea, arthralgia, myalgia, sore throat, headache, chest pain.

Other: Evaluation of Pulmonary and Extrapulmonary Impacts of COVID-19 on Young Adults

healthy control group

ACTIVE COMPARATOR

In this group cases, who were not infected with COVID-19 will be allocated.

Other: Evaluation of Pulmonary and Extrapulmonary Impacts of COVID-19 on Young Adults

Interventions

Evaluation of Pulmonary and Extrapulmonary Impacts of COVID-19 on Young Adults OTHER

Participants' upper extremity and lower extremity muscle strength, 6-minute walking distance, O2 saturation, posture evaluation, spirometric evaluation, pain threshold, pain intensity, dyspnea, and leg fatigue measurements will be recorded. In addition to these measurements, general fatigue, quality of life, depression, physical activity level, sleep quality parameters will be evaluated and the data obtained will be analyzed with appropriate statistical methods.

healthy control group; post COVID-19 group

Eligibility Criteria

• Age: 18 Years - 45 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• volunteers who are aged between 18-45 years
• cases, who were infected with COVID-19 and had at least 12 weeks after diagnosis
• cases, who have no symptoms of COVID-19 such as fever, cough, ageusia, anosmia, diarrhea, arthralgia, myalgia, sore throat, headache, chest pain

You may not qualify if:

• those have any cardiac or pulmonary disease history
• those have diagnoses of any psychological disease (major depression, anxiety disorder, etc.)
• those have any neurological or orthopaedic disease which hinders participation in physical activity

Sponsors & Collaborators

• Istanbul Arel University: lead

Study Sites (1)

Istanbul Arel University

Istanbul, Zeytinburnu, 34010, Turkey (Türkiye)

Location

Related Publications (3)

• Tuzun S, Keles A, Okutan D, Yildiran T, Palamar D. Assessment of musculoskeletal pain, fatigue and grip strength in hospitalized patients with COVID-19. Eur J Phys Rehabil Med. 2021 Aug;57(4):653-662. doi: 10.23736/S1973-9087.20.06563-6. Epub 2021 Jan 4.

  PMID: 33393277 RESULT

• Lee CC, Wu HJ, Chiou WB. Reminders of COVID-19 social distancing can intensify physical pain. Br J Soc Psychol. 2022 Apr;61(2):587-598. doi: 10.1111/bjso.12498. Epub 2021 Sep 12.

  PMID: 34510481 RESULT

• Tanriverdi A, Savci S, Kahraman BO, Ozpelit E. Extrapulmonary features of post-COVID-19 patients: muscle function, physical activity, mood, and sleep quality. Ir J Med Sci. 2022 Jun;191(3):969-975. doi: 10.1007/s11845-021-02667-3. Epub 2021 Jun 2.

  PMID: 34080125 RESULT

MeSH Terms

Conditions

COVID-19; Respiratory Aspiration

Condition Hierarchy (Ancestors)

Pneumonia, Viral; Pneumonia; Respiratory Tract Infections; Infections; Virus Diseases; Coronavirus Infections; Coronaviridae Infections; Nidovirales Infections; RNA Virus Infections; Lung Diseases; Respiratory Tract Diseases; Respiration Disorders; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: DOUBLE
• Who Masked: INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: SCREENING
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Lecturer, Department of Physiotherapy and Rehabilitation, Faculty of Health Sciences

Study Record Dates

• First Submitted: March 13, 2022
• First Posted: March 16, 2022
• Study Start: April 4, 2022
• Primary Completion: April 5, 2025
• Study Completion: April 5, 2025
• Last Updated: April 30, 2025

Record last verified: 2025-04

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)