Assessment of the Prognostic Value of the Thickness of the Quadriceps and Abdominal Muscles Measured by Ultrasound for 28-day Mortality in Postoperative ICU Patients

NCT05276921 | Completed

• 1 other identifier: DRANSART BOUDINA 2019
• Study Type: observational
• Target: 150
• Locations: 1 country
• Sites: 1

Brief Summary

Ultrasound measurement of muscle thickness, particularly of the quadriceps, can be used to highlight a reduction in lean mass. Sarcopenia is annvoluntary loss of lean mass, and it is a frequent and major problem in the intensive care unit (ICU). Sarcopenia is associated with significant morbidity and mortality, as previously demonstrated by CT scan measurements. Nevertheless, due to its nature and cost, it does not appears reasonable to perform CT sarcopenia evaluation in all ICU patients. Described in the literature as evolving rapidly upon admission to ICU, accurate assessment of this loss of muscle mass would allow early detection of sarcopenia and adaptation of therapeutic management, particularly nutritional and rehabilitative. There are many advantages to evaluating sarcopenia by ultrasound measurement: simple, rapid, achievable at the patient's bedside, no exposure to radiation, non-invasive, and low cost. The abdominal muscles (external oblique, internal oblique, transverse) constitute the accessory respiratory muscles. Easily accessible by ultrasound, they are a potential target for the evaluation of sarcopenia, which could be responsible for ventilatory withdrawal failures, prolonged stays in intensive care and associated complications. The combined ultrasound measurement of the quadriceps and accessory respiratory muscles in ICU patients therefore appears to be an innovative approach. Considering the ease of implementation, the validity of ultrasound (confirmed in the literature), and the safety of the technique, we wish to evaluate the link between the muscle mass at arrival in the postoperative Intensive Care Unit of the Dijon University Hospital by ultrasound measurement of the quadriceps and accessory respiratory muscles, and: mortality, duration of mechanical ventilation, length of stay and occurrence of intercurrent events.

Conditions

Sarcopenia ICU Ultrasound

Outcome Measures

Primary Outcomes (1)

• Ultrasound mesure of thickness of quadriceps and abdominal muscles

  at inclusive

Study Arms (1)

Patient

Postoperative ICU patient

Other: ultrasound

Interventions

ultrasound OTHER

Quadriceps and abdominal muscle ultrasonography

Patient

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

postoperative ICU patient

You may qualify if:

• Person who has not opposed (or non-opposition of health care proxy for patients who are comatose or under the influence of sedative drugs) after receiving information about the study
• All adult patients admitted to the postoperative intensive care unit.

You may not qualify if:

• Protected adult or minor
• Pregnant or breastfeeding woman
• Lower limb amputation
• Refusal to participate of the patient or health care proxy
• Patient with pre-existing neuromuscular condition, tetra or paraplegia
• Morbid obesity as defined by BMI ≥ 40
• BPCO stage ≥ 3; heart failure with LVEF \< 50%; patients with symptomatic valvulopathy

Sponsors & Collaborators

• Centre Hospitalier Universitaire Dijon: lead

Study Sites (1)

Chu Dijon Bourgogne

Dijon, France

Location

MeSH Terms

Interventions

High-Energy Shock Waves

Intervention Hierarchy (Ancestors)

Ultrasonic Waves; Sound; Radiation, Nonionizing; Radiation; Physical Phenomena

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 28, 2022
• First Posted: March 14, 2022
• Study Start: December 20, 2019
• Primary Completion: May 28, 2020
• Study Completion: June 26, 2020
• Last Updated: March 14, 2022

Record last verified: 2022-02

Locations

FR (1)