Plaque Stability and Metabolomics in Coronary Heart Disease

NCT05270330 | Unknown

• 1 other identifier: 2021BJ-02
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

At present, the investigators don't know the relationship between plaque stability and the metabonomics changes. In the present study, investigators will evaluate the plaque stability by intravascular unltrasound in stable coronary heart patients, and metabonomics was also assessed by high throughput sequencing. Statistic analysis were carried out to analyze the correlation between plaque stability and metabonomics changes among these study patients.

Conditions

Coronary Artery Disease

Keywords

plaque stability; metabonomics

Outcome Measures

Primary Outcomes (1)

• Plaque stability

  The investigators will use the intravascular ultrasound to assess the coronary plaque stability of the patients with coronary heart disease.

  07/01/2021-07/31/2024

Secondary Outcomes (1)

• Metabonomics

  07/01/2021-07/31/2024

Interventions

This is an observational study, we don't have any interventions. OTHER

No intervention

Eligibility Criteria

• Age: 18 Years - 90 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients diagnosed with stable coronary heart disease and assessed for plaque stability by IVUS will be recruited in our study.

You may qualify if:

• Patients who diagnosed with stable coronary heart disease and evaluated for plaque stability by IVUS will be recruited.

You may not qualify if:

• renal insufficiency with serum creatinine \> 20 mg/L;
• regnant/lactating women, or the women receive hormone replacement therapy in premenopausal or postmenopausal;
• patients have a history of abusing alcohol or other drugs in the past two years, active hepatitis, cirrhosis;
• endocrine abnormalities without therapy (diabetic ketoacidosis, thyroid disease, etc.);
• The body's inflammatory disease, rheumatoid arthritis, osteoarthritis, ulcerative bowel disease, systemic lupus erythematosus (sle), etc.), myositis/myopathy, cancer;
• Dilated cardiomyopathy, valvular heart disease, persistent atrial fibrillation;
• patients recently injured;（8）Other researchers don't agree to join this study.

Sponsors & Collaborators

• Shaanxi Provincial People's Hospital: lead

Study Sites (1)

Shaanxi Provincial People's Hospital

Xi'an, Shaanxi, 710061, China

RECRUITING

MeSH Terms

Conditions

Coronary Artery Disease

Condition Hierarchy (Ancestors)

Coronary Disease; Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Arteriosclerosis; Arterial Occlusive Diseases; Vascular Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: January 22, 2022
• First Posted: March 8, 2022
• Study Start: July 1, 2021
• Primary Completion: July 31, 2024
• Study Completion: July 31, 2024
• Last Updated: March 8, 2022

Record last verified: 2022-03

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)