NCT05268224

Brief Summary

Investigation of a tear-based, lab-developed biological test for breast cancer, as a supplemental tool to current screening recommendations for women with dense breast tissue will explore if a tear-based biological test can be used as a support tool in the breast cancer screening protocol for women with dense breast tissue. The test was designed and validated by Namida Lab, Inc., a high complexity Clinical Laboratory Improvement Amendments (CLIA) certified lab.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
1,500

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Oct 2021

Typical duration for all trials

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

October 1, 2021

Completed
5 months until next milestone

First Submitted

Initial submission to the registry

February 24, 2022

Completed
11 days until next milestone

First Posted

Study publicly available on registry

March 7, 2022

Completed
2.6 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

October 1, 2024

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

October 1, 2024

Completed
Last Updated

December 11, 2023

Status Verified

December 1, 2023

Enrollment Period

3 years

First QC Date

February 24, 2022

Last Update Submit

December 7, 2023

Conditions

Outcome Measures

Primary Outcomes (1)

  • Accuracy Measure

    Degree of closeness of categorization by a tear-based biological test scores to imaging techniques

    3 months

Study Arms (1)

Dense Breast

Women mammographically categorized as having either heterogeneously dense or extremely dense breast tissue.

Diagnostic Test: Schirmer Strip

Interventions

Schirmer StripDIAGNOSTIC_TEST

A tear-based screening assay for breast cancer developed and validated by Namida Lab, Inc., a high complexity CLIA-certified lab. It consists of two parts: tear sample collection using a Schirmer Strip and a clinical lab-developed test that measures protein biomarkers for breast cancer screening.

Dense Breast

Eligibility Criteria

Age18 Years - 100 Years
Sexfemale(Gender-based eligibility)
Gender Eligibility DetailsEligibility is based on individuals who biologically qualify to participate in yearly breast cancer screening and who have dense breast tissue.
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Women who have been mammographically catagorized as having heterogenously dense or extremely dense breast tissue.

You may qualify if:

  • Categorized as having heterogeneously dense or extremely dense tissue 18 years of age or older Able to understand the informed consent process Willing to comply with all study procedures

You may not qualify if:

  • Have an active eye infection Categorized as having fibro glandular densities or fatty breast tissue Currently diagnosed or are receiving treatment for breast cancer Under 18 years of age

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Namida Lab

Fayetteville, Arkansas, 72703, United States

RECRUITING

Central Study Contacts

Anna Daily, PhD

CONTACT

Prashanth Ravishankar, PhD

CONTACT

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

February 24, 2022

First Posted

March 7, 2022

Study Start

October 1, 2021

Primary Completion

October 1, 2024

Study Completion

October 1, 2024

Last Updated

December 11, 2023

Record last verified: 2023-12

Data Sharing

IPD Sharing
Will not share

Individual participant data is not intended to be shared with other researchers at this time.

Locations