Usefulness of Video-Based Intervention in Helping Participants Encourage Their Families to Get Tested for BRCA Gene Mutations

NCT05264532 | Completed DMC

• 2 other identifiers: OSU-17312NCI-2018-00756
• Study Type: interventional
• Target: 58
• Locations: 1 country
• Sites: 1

Brief Summary

This trial studies how well a video-based intervention works in helping participants encourage their families to get tested for BRCA gene mutations. Testing in families with BRCA gene mutations can allow for risk management and reduction with the overall goal of reducing cancer burden. Video-based intervention sent via text messages may help participants easily share information about BRCA gene mutations with family members.

Conditions

BRCA1 Gene Mutation; BRCA2 Gene Mutation

Outcome Measures

Primary Outcomes (2)

• Impact of a web-based video delivered via text message or shared on social media on information sharing among relatives belonging to families with BRCA gene mutations

  Measure participant-reported information sharing among family members prior to receipt of the video and after the video. There is no previously validated scale/set of items for this. Items are investigator created and assess likelihood to share information with family members on a Likert scale.

  Up to 3 years

• Impact of participant-reported family dynamics on information sharing

  Brief family relationship scale will be used to determine whether differences in family dynamics could be associated with differences in family sharing. A higher score for the cohesion and expressiveness subscales generally indicates more positive dynamics and a the conflict subscale is inversely scored.

  Up to 3 years

Study Arms (2)

Arm A (video via text message)

EXPERIMENTAL

Participants receive a 2-minute information-graphic video via text message consisting of misconceptions and issues that may be paramount when discussing mutation status with relatives that they can share with family via text message, email, or social media.

Other: Informational Intervention; Other: Survey Administration

Arm B (letter via standard U.S. mail)

ACTIVE COMPARATOR

Participants receive family letter via U.S. postal service mail consisting of misconceptions and issues that may be paramount when discussing mutation status with relatives.

Other: Informational Intervention; Other: Survey Administration

Interventions

Survey Administration OTHER

Ancillary studies

Arm A (video via text message); Arm B (letter via standard U.S. mail)

Informational Intervention OTHER

Receive information-graphic video

Arm A (video via text message)

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Individuals who test positive for mutations in BRCA1 or BRCA2 are eligible for this study
• Family members who receive the video message/family letter will be invited to participate

Sponsors & Collaborators

• Ohio State University Comprehensive Cancer Center: lead

Study Sites (1)

Ohio State University Comprehensive Cancer Center

Columbus, Ohio, 43210, United States

Location

Related Links

• The Jamesline

Study Officials

• Leigha Senter, LGC

  Ohio State University Comprehensive Cancer Center

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: HEALTH SERVICES RESEARCH
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: June 25, 2018
• First Posted: March 3, 2022
• Study Start: April 5, 2018
• Primary Completion: June 7, 2025
• Study Completion: June 7, 2025
• Last Updated: February 10, 2026

Record last verified: 2026-02

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)