NCT05258630

Brief Summary

This randomized pilot trial of the Diabetes Homeless Medication Support intervention vs. brief diabetes education will test the perception and feasibility of anticipated study procedures and refine randomization and blinding.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
38

participants targeted

Target at below P25 for phase_2 diabetes-mellitus-type-2

Timeline
Completed

Started Feb 2022

Typical duration for phase_2 diabetes-mellitus-type-2

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

February 17, 2022

Completed
6 days until next milestone

Study Start

First participant enrolled

February 23, 2022

Completed
5 days until next milestone

First Posted

Study publicly available on registry

February 28, 2022

Completed
1.2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

April 27, 2023

Completed
3 months until next milestone

Study Completion

Last participant's last visit for all outcomes

July 12, 2023

Completed
1.3 years until next milestone

Results Posted

Study results publicly available

November 7, 2024

Completed
Last Updated

November 7, 2024

Status Verified

November 1, 2024

Enrollment Period

1.2 years

First QC Date

February 17, 2022

Results QC Date

May 13, 2024

Last Update Submit

November 6, 2024

Conditions

Outcome Measures

Primary Outcomes (2)

  • Experience During the Intervention

    The acceptability of the intervention to participants will be measured by the Client Satisfaction Questionnaire, 8-item version, with a score range from 8-32, higher score indicating higher satisfaction.

    Assessed at 16 weeks

  • Retention in Assessments

    The study team will track enrolled participants who complete both post-treatment assessment visits (12-16 week post-treatment assessment and 24-30 week assessment). Retention will be measured as the percentage of enrolled participants who complete both assessments as assessed at 30 weeks.

    Assessed at 30 weeks

Secondary Outcomes (3)

  • Change in Glycemic Control

    Assessed at Baseline, 16 weeks, and 30 weeks.

  • Psychological Wellness

    Assessed at baseline, 16 weeks, and 30 weeks

  • Diabetes Medication Adherence

    Assessed at Baseline, 16 weeks, and 30 weeks

Study Arms (2)

D-Homes intervention

EXPERIMENTAL

Behavioral treatments by a diabetes wellness coach as defined below.

Behavioral: Diabetes Homeless Medication Support (D-Homes)Behavioral: Enhanced usual care

Enhanced usual care

ACTIVE COMPARATOR

Brief diabetes educational session by a diabetes wellness coach.

Behavioral: Enhanced usual care

Interventions

There will be 10 sessions offered within 12 weeks to participants. Sessions will last approximately 30 minutes. During sessions a diabetes wellness coach will use behavioral activation and motivational interviewing to get to know participants and set goals to improve diabetes care. The coach will encourage a focus on medication adherence behaviors to the extent that participants are willing. The coach will also help with resource and care coordination. The coach will also provide a tailored tool to the patient's needs/goals and tailored diabetes education as needed.

D-Homes intervention

Trained diabetes wellness coaches will provide an approximately 15 minutes of instruction about the basic concepts of diabetes. They will use handouts aligned with American Diabetes Association guidelines. They will read these with participants and answer basic questions. Handouts will cover (1) general diabetes knowledge, (2) healthy eating with diabetes, (3) physical activity with diabetes. The coach will also provide a general tool to support medication adherence (e.g. pillbox).

D-Homes interventionEnhanced usual care

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Age 18 yrs. or older
  • English-speaking
  • Homelessness by federal definition (HEARTH ACT) in the past 24 mos.
  • Self-reported diagnosis of type 2 diabetes with A1c \>7.5%, later verified in medical record and study point-of-care lab test.
  • Plan to stay in local area or be reachable by phone for the next 24 weeks
  • Willingness to work on medication adherence and diabetes self-care

You may not qualify if:

  • Inability to provide informed consent (e.g., presence of a legal guardian, prisoners)
  • Active psychosis or intoxication precluding ability to give informed consent
  • Pregnant or lactating people

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Hennepin Healthcare

Minneapolis, Minnesota, 55415, United States

Location

Related Publications (1)

  • Vickery KD, Gelberg L, Hyson AR, Strother E, Carter J, Oranday Perez O, Franco M, Kavistan S, Gust S, Adair E, Anderson-Campbell A, Brito L, Butler A, Robinson T, Connett J, Evans MD, Emmons KM, Comulada WS, Busch AM. Pilot trial results of D-HOMES: a behavioral-activation based intervention for diabetes medication adherence and psychological wellness among people who have been homeless. Front Psychiatry. 2024 Feb 29;15:1329138. doi: 10.3389/fpsyt.2024.1329138. eCollection 2024.

MeSH Terms

Conditions

Diabetes Mellitus, Type 2

Condition Hierarchy (Ancestors)

Diabetes MellitusGlucose Metabolism DisordersMetabolic DiseasesNutritional and Metabolic DiseasesEndocrine System Diseases

Limitations and Caveats

Due to the limited resources available in the grant (career development) and delays due to the coronavirus (COVID-19) pandemic, recruitment was closed before reaching our targeted number of participants.

Results Point of Contact

Title
Katherine Diaz Vickery
Organization
Hennepin Healthcare Research Institute

Study Officials

  • Katherine D Vickery, MD, MSc

    Hennepin Healthcare Research Institute

    PRINCIPAL INVESTIGATOR

Publication Agreements

PI is Sponsor Employee
No
Restrictive Agreement
No

Study Design

Study Type
interventional
Phase
phase 2
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Masking Details
Study staff completing post-treatment assessments will be blinded to study condition allocation.
Purpose
TREATMENT
Intervention Model
PARALLEL
Model Details: The study team will use 1 to 1 allocation to intervention vs. comparison arms. They will stratify based on more and less stable housing in the 12 mo. prior to enrollment.
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

February 17, 2022

First Posted

February 28, 2022

Study Start

February 23, 2022

Primary Completion

April 27, 2023

Study Completion

July 12, 2023

Last Updated

November 7, 2024

Results First Posted

November 7, 2024

Record last verified: 2024-11

Data Sharing

IPD Sharing
Will not share

As this work is pilot data to inform treatment development for later efficacy testing, we will not share individual participant data. The study team will submit for publication an overall paper describing our results and how they informed future intervention development.

Locations