Comparison Between Analog Neurocognitive Tests Conducted by a Trained Test Leader Versus Self-administered Digital Tests

NCT05253612 | Completed

• 1 other identifier: 2021-01095
• Study Type: interventional
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

The study has a randomized crossover design including qualitative interviews of the participant's test experiences. Healthy participants, ≥60 years are eligible to participate in the study. Cognitive function will be measured by using the International Study Group of Postoperative Cognitive Dysfunction (ISPOCD) test battery and the Mindmore digital test battery. The participants will self-report their likelihood of depression with the geriatric depression scale-15, their user experience of the digital test by a modified version of System Usability scale, and answer questionnaires targeting their experiences of the test sessions. Furthermore, concentration difficulties, according to the Swedish Quality of Recovery-scale will also be measured.

Conditions

Neurocognitive Decline; Feasibility; Costs; Interviews

Outcome Measures

Primary Outcomes (1)

• equivalence between the two tests

  If the data is normal distributed Pearson correlation coefficient will be used to measure the association between ISPOCD and Mindmore four cognitive domains. If the data is non normally distributed Spearman rank correlation will be used. The values for the correlation coefficient irrespectively if using Person or Spearman range between -1.0 and 1.0. A correlation of -1.0 shows a perfect negative correlation, while a correlation of 1.0 shows a perfect positive correlation. However, a correlation equal to 0 does not imply the absence of association

  through study completion, an average of 6 months

Secondary Outcomes (6)

• Usability of the digital test version

  through study completion, an average of 6 months

• Acceptability and Feasibility (I)

  through study completion, an average of 6 months

• Acceptability and Feasibility (II)

  through study completion, an average of 6 months

• Concentration difficulties the past 24 hours

  through study completion, an average of 6 months

• Depression screening

  through study completion, an average of 6 months

Study Arms (2)

ISPOCD test battery

OTHER

The participants will be randomized to start with ISPOCD test battery followed by Mindmore digitalized cognitive test battery with 2 weeks passing between the cognitive testing for both groups

Diagnostic Test: Analog testing conducted by a trained test leader using, ISPOCD test battery; Diagnostic Test: self-administered Mindmore digital cognitive screening battery

Mindmore digitalized cognitive test battery

OTHER

Strating with Mindmore digitalized cognitive test battery followed by ISPOCD test battery, with 2 weeks passing between the cognitive testing for both groups

Diagnostic Test: Analog testing conducted by a trained test leader using, ISPOCD test battery; Diagnostic Test: self-administered Mindmore digital cognitive screening battery

Interventions

Analog testing conducted by a trained test leader using, ISPOCD test battery DIAGNOSTIC_TEST

Cognitive function will be measured by using the International Study Group of Postoperative Cognitive Dysfunction (ISPOCD) analog test battery v

ISPOCD test battery; Mindmore digitalized cognitive test battery

self-administered Mindmore digital cognitive screening battery DIAGNOSTIC_TEST

Cognitive function will be measured by using the Mindmores digital test battery

ISPOCD test battery; Mindmore digitalized cognitive test battery

Eligibility Criteria

• Age: 60 Years+
• Gender Eligibility Details: We will ask for the biological gender
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• \> 59 years of age
• ability to read and speak Swedish,

You may not qualify if:

• suffering from a nervous system disease,
• suffering from a severe psychiatric disorder
• alcoholism
• drug dependence
• severe visual or auditory disorder.

Sponsors & Collaborators

• Karolinska Institutet: lead

Study Sites (1)

Ulrica Nilsson

Stockholm, 141 83, Sweden

Location

Related Publications (1)

• Amirpour A, Eckerblad J, Bergman L, Nilsson U. Comparing analog and digital neurocognitive tests with older adults: a study of the ISPOCD battery vs. a digital test battery from Mindmore. BMC Geriatr. 2024 Jan 8;24(1):34. doi: 10.1186/s12877-023-04648-w.

  PMID: 38191318 RESULT

Study Officials

• Ulrica Nilsson, Professor

  Karolinska Institutet

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: SCREENING
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Model Details: The participants will be randomized to one of two conditions: 1) ISPOCD test battery followed by Mindmore digitalized cognitive test battery, or 2) Mindmore digitalized cognitive test battery followed by ISPOCD test battery, with 2 weeks passing between the cognitive testing for both groups

Study Record Dates

• First Submitted: December 22, 2021
• First Posted: February 24, 2022
• Study Start: February 17, 2022
• Primary Completion: April 5, 2022
• Study Completion: April 5, 2022
• Last Updated: March 6, 2025

Record last verified: 2025-03

Data Sharing

• IPD Sharing: Will not share

Locations

SE (1)