NCT05252312

Brief Summary

Like many other animals, humans produce nonverbal signals including screams, grunts, roars, cries and laughter across a variety of contexts.Due to their acoustic structure, nonverbal vocalizations and valanced speech (e.g., yelling) are also likely to elicit predictable physiological, perceptual or behavioural responses in the receiver of the signal (the listener). This is critical if researchers are to gain a comprehensive understanding of the broad range of mechanisms and the evolved functions of acoustic communication. Therefore, in this research, investigators will examine specifically how exposure to vocal stimuli affects both the cognitive and biological responses of the listener.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
2,000

participants targeted

Target at P75+ for all trials

Timeline
11mo left

Started Nov 2022

Longer than P75 for all trials

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Progress79%
Nov 2022Apr 2027

First Submitted

Initial submission to the registry

February 2, 2022

Completed
21 days until next milestone

First Posted

Study publicly available on registry

February 23, 2022

Completed
9 months until next milestone

Study Start

First participant enrolled

November 29, 2022

Completed
4.3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

April 1, 2027

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

April 1, 2027

Last Updated

May 6, 2026

Status Verified

May 1, 2026

Enrollment Period

4.3 years

First QC Date

February 2, 2022

Last Update Submit

May 5, 2026

Conditions

Keywords

nonverbal signals of the vocalizernonlinguistic acoustic parametersphysiological responsesperceptual responsesbehavioural responses

Outcome Measures

Primary Outcomes (3)

  • Proportion of correct responses in a forced-choice task after vocal stimuli

    Participants will be asked to judge vocal stimuli Example : "Of the two baby cries you listened to, which one do you think shows the most distress"

    Immediately after the vocal stimuli

  • Numerical values of judgements along a scale

    Participants will be asked to judge vocal stimuli Example : participants may be asked to judge, along a gradient (from 0 to 100), "how consistent the distress of the baby you heard is to you".

    Immediately after the vocal stimuli

  • Response time (second)

    Participants will be asked to judge vocal stimuli In this case, the participant is instructed to respond as soon as possible. The response time for each stimulus is then systematically measured

    Immediately after the vocal stimuli

Secondary Outcomes (5)

  • Heart rate (bpm)

    During the vocal stimuli

  • Skin conductance (Siemens)

    During the vocal stimuli

  • Skin temperature (°C)

    During the vocal stimuli

  • Nociception Level Index (NOL)

    During the vocal stimuli

  • Pupillary diameter (millimeter)

    During the vocal stimuli

Study Arms (1)

Healthy adult population aged 18 to 80 years

After listening to acoustic stimuli, participants will be asked to judge these stimuli on relevant evaluation criteria (e.g., "how distressed does this person sound?").

Behavioral: Psycho-acoustic tests

Interventions

Listeners' cognitive and biological responses to vocal stimuli will be tested using psycho-acoustic tests. After listening to acoustic stimuli, participants will be asked to judge these stimuli on relevant evaluation criteria (e.g., "how distressed does this person sound?"). These stimuli might be human voices, animal voices or synthetic voices Physiological measures will be simultaneously taken using an array of complimentary, non-invasive techniques such as the Nociception Level (NOL) Index or video pupillometry

Healthy adult population aged 18 to 80 years

Eligibility Criteria

Age18 Years - 80 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Healthy adult population aged 18 to 80 years

You may qualify if:

  • \- Participant should be affiliated or entitled to a social security scheme

You may not qualify if:

  • Pregnancy
  • Hearing impairment, speech production disorders or major health problems.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

CHU Saint-Etienne

Saint-Etienne, 42055, France

RECRUITING

Study Officials

  • ROLAND PEYRON, MDPHD

    CHU DE SAINT-ETIENNE

    PRINCIPAL INVESTIGATOR
  • Nicolas MATHEVON, PhD

    University of Saint-Etienne, France

    STUDY CHAIR

Central Study Contacts

Study Design

Study Type
observational
Observational Model
OTHER
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

February 2, 2022

First Posted

February 23, 2022

Study Start

November 29, 2022

Primary Completion (Estimated)

April 1, 2027

Study Completion (Estimated)

April 1, 2027

Last Updated

May 6, 2026

Record last verified: 2026-05

Data Sharing

IPD Sharing
Will not share

Locations