Outcome of Discharged HFmrEF Patients

NCT05240118 | Completed

• 1 other identifier: 2021/12
• Study Type: observational
• Target: 1,693
• Locations: 0 countries
• Sites: N/A

Brief Summary

This study aimed to define the independent risk factors related cardiac events (cardiac death or heart failure-related hospitalization) among heart failure with mildly reduced ejection fraction (HFmrEF) patients who discharged from the Xiangtan Central Hospital. Through the long-term follow-up the cardiovascular outcome of patients being discharged from the hospital, the risk factors related to cardiovascular outcome (cardiac death or heart failure-related hospitalization) will be explored to provide clinical evidence to intervene the discharged HFmrEF patients aiming to improve patients outcome in the future clinical practice.

Conditions

Heart Failure With Mid Range Ejection Fraction

Outcome Measures

Primary Outcomes (1)

• Long-term risk factors related to cardiac events (cardiac death or heart failure-related rehospitalization) in discharged patients with heart failure with mildly reduced ejection fraction

  Primary Outcome Measure: 1.Long-term risk factors related to cardiac events (cardiac death or heart failure-related rehospitalization) in discharged patients with heart failure with mildly reduced ejection fraction The clinical features of hospitalized heart failure with mildly reduced ejection fraction (HFmrEF, EF 41-49%) will be analyzed retrospectively by reviewing their medical records, laboratory and clinical imaging examination results during initial hospitalization, clinical outcome up to the study end will be obtained through clinical visit and telephone call.

  The last patients would be clinically followed-up until August 31, 2021 per clinical visit or telephone call.

Secondary Outcomes (1)

• Long-term risk factors related to all-cause death in discharged patients with heart failure with mildly reduced ejection fraction

  The last patients would be clinically followed-up until August 31, 2021 per clinical visit or telephone call

Study Arms (1)

HFmrEF Group

HFmrEF (Heart failure with mildly reduced ejection fraction): ESC Guideline heart failure 2021: patients with LVEF 41-49%. non-cardiac events group versus cardiac events (cardiac death or heart failure-related rehospitalization) group

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients who attended the Xiangtan Cengtral Hospital in the time period between January 1, 2015 and August 31, 2020 with the diagnosis of HFmrEF.

You may qualify if:

• Diagnosis: Heart failure with mildly reduced ejection fraction (HFmrEF) Presence of symptoms and/or signs of HF, and a mildly reduced LVEF (41- 49%); Elevated natriuretic peptides (BNP \>35 pg/mL or NT-proBNP \>125 pg/mL); Other evidence of structural heart disease.

You may not qualify if:

• none

Sponsors & Collaborators

• Xiangtan Central Hospital: lead

Related Publications (1)

• Liu Z, Zhu Y, Chen S, Wu M, Huang H, Peng K, Zhang L, Zhao W, Peng X, Li N, Zhang H, Zhou Y, Peng Y, Fan J, Zeng J. Sex differences in patients with heart failure and mildly reduced left ventricular ejection fraction. Sci Rep. 2023 Apr 26;13(1):6832. doi: 10.1038/s41598-023-33733-8.

  PMID: 37100821 DERIVED

Study Officials

• Jianping Zeng, M.D.

  Xiangtan Central Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Dean, Xiangtan Central Hospital ,Director of cardiovascular clinic, Clinical Professor

Study Record Dates

• First Submitted: December 3, 2021
• First Posted: February 15, 2022
• Study Start: January 1, 2015
• Primary Completion: August 31, 2020
• Study Completion: August 31, 2021
• Last Updated: February 15, 2022

Record last verified: 2022-02

Data Sharing

• IPD Sharing: Will not share