Secretin in Refeeding

NCT05235867 | Recruiting

• 1 other identifier: IRB#21-001489
• Study Type: observational
• Target: 10
• Locations: 1 country
• Sites: 1

Brief Summary

Patients with restrictive-type anorexia nervosa who are admitted to the hospital for feeding often urinate excessive amounts. Others have changes in the way that they handle acid and base. These issues prolong hospitalizations. Current data suggest that one hormone--named secretin--may control both urine output and how the body handles acid and base. This study will evaluate whether secretin levels are different in anorexic patients who urinate an excessive amount compared to those who urinate normal amounts. For this study, patients will have one extra blood draw before and after one meal during their hospitalization. The blood draw before the meal coincides with a standard of care blood draw. Also after the meal, subjects will be asked to provide one extra urine sample. Information from subject's medical records will also be used.

Conditions

Anorexia in Adolescence

Outcome Measures

Primary Outcomes (1)

• Change in secretin

  Change in secretin value from pre- to post- meal

  1 hour

Secondary Outcomes (1)

• Change in serum bicarbonate

  1 hour

Study Arms (2)

dumpers

* male and female patients * age 13-24 years * diagnosis of restrictive-type anorexia nervosa * hospitalization for nutritional support * \>4 cc/kg/day of urine output (a.k.a. "fluid dumpers"; n=5)

non-dumpers

* male and female patients * age 13-24 years * diagnosis of restrictive-type anorexia nervosa * hospitalization for nutritional support * \<2 cc/kg/d of urine output (a.k.a. "non-dumpers"; n=5)

Eligibility Criteria

• Age: 13 Years - 24 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Adolescents with restrictive-type anorexia hospitalized for medical nutritional stabilization.

You may qualify if:

• Group 1:
• male and female patients
• age 13-24 years
• diagnosis of restrictive-type anorexia nervosa
• hospitalization for nutritional support
• \>4 cc/kg/day of urine output (a.k.a. "fluid dumpers"; n=5)
• Group 2:
• male and female patients
• age 13-24 years
• diagnosis of restrictive-type anorexia nervosa
• hospitalization for nutritional support
• \<2 cc/kg/d of urine output (a.k.a. "non-dumpers"; n=5)

You may not qualify if:

• hold
• Anti-depressant, anti-psychotic, or anticonvulsant medications
• Previous hospitalization within the past 6 months
• Underlying metabolic disorder not related to anorexia nervosa (including chronic kidney disease, renal tubular disorders, and underlying endocrine disorders)
• Pregnancy
• NG or G-tube feeds after day 2 of hospitalization
• \> 10% of nutritional needs from supplemental feeds

Sponsors & Collaborators

• University of California, Los Angeles: lead

Study Sites (1)

University of California, Los Angeles (UCLA)

Los Angeles, California, 90095, United States

RECRUITING

Biospecimen

Retention: SAMPLES WITHOUT DNA

serum and urine

Central Study Contacts

Misciel Macaraig

CONTACT

310-825-0922; mbmacaraig@mednet.ucla.edu

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: February 1, 2022
• First Posted: February 11, 2022
• Study Start: February 1, 2022
• Primary Completion (Estimated): June 30, 2027
• Study Completion (Estimated): December 31, 2027
• Last Updated: February 12, 2026

Record last verified: 2026-02

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)