Prognostic Significance of COVID-19 MSCT Chest Findings on Short Term Disease Progression

NCT05235373 | Completed

• 1 other identifier: TEJB-D-22-00019
• Study Type: observational
• Target: 300
• Locations: 1 country
• Sites: 1

Brief Summary

Background: CT has been used on a massive scale to help identify and investigate suspected or confirmed cases of COVID-19 pneumonia. This study aimed to assess the prognostic significance of the chest findings MSCT of Covid-19 patients and to determine if prognosis can rely on the initial CT imaging. Methods: The study design was retrospective cohort study. It was carried out on 300 patients presented to the chest outpatient clinics in Benha university hospitals and Elabbasyia chest hospital with clinical picture suggestive of COVID 19 infection. The CT finding were then compared to the short-term clinical outcome of the patients (1-3weeks), acquired from the hospital patient data archive. According to the progression of the respiratory symptoms (include; dyspnea, respiratory rate and O2 saturation), the short-term clinical outcome of the patients was classified into 4 groups; Group A: (mild cases), Group B: (moderate cases), Group C: (sever cases), and Group D: (fatality cases).

Conditions

COVID-19; Infection Viral

Keywords

COVID-19; MSCT; chest

Outcome Measures

Primary Outcomes (1)

• correlation between initial CT findings with short term clinical outcome

  The CT finding were then compared to the short-term clinical outcome of the patients (1-3weeks), acquired from the hospital patient data archive; respiratory symptoms (dyspnea, respiratory rate and O2 saturation),

  3 weeks

Study Arms (4)

group A: (mild cases): with no progression of the respiratory symptoms.

multislice CT finding,The CT finding were then compared to the short-term clinical outcome of the patients (1-3weeks), acquired from the hospital patient data archive.

group B: (moderate cases): who have worsened disease but not requiring ICU admission.

multislice CT finding,The CT finding were then compared to the short-term clinical outcome of the patients (1-3weeks), acquired from the hospital patient data archive.

Group C: (sever cases): patient who needed ICU admission.

multislice CT finding,The CT finding were then compared to the short-term clinical outcome of the patients (1-3weeks), acquired from the hospital patient data archive.

Group D: (fatality cases): cases who died with or without ICU admission).

multislice CT finding,The CT finding were then compared to the short-term clinical outcome of the patients (1-3weeks), acquired from the hospital patient data archive.

Eligibility Criteria

• Age: 20 Years - 90 Years
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

presented to the chest outpatient clinics in Benha university hospitals and Elabbasyia chest hospital with clinical picture suggestive of COVID 19 infection during the period from April 2020 to December 2020.

You may not qualify if:

• Patients with positive RT PCR test for COVID 19 and negative chest CT findings.
• Patients with other pre-existing lung pathologies in the chest CT.

Sponsors & Collaborators

• Benha University: lead

Study Sites (1)

Benha University hospital

Banhā, Kalyobia, 13512, Egypt

Location

MeSH Terms

Conditions

COVID-19; Virus Diseases

Condition Hierarchy (Ancestors)

Pneumonia, Viral; Pneumonia; Respiratory Tract Infections; Infections; Coronavirus Infections; Coronaviridae Infections; Nidovirales Infections; RNA Virus Infections; Lung Diseases; Respiratory Tract Diseases

Study Officials

• AMIRA HM Allam, MD

  chest department, Faculty of medicine, Benha University, Egypt

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: assistant professor of chest diseases and tuberculosis

Study Record Dates

• First Submitted: February 8, 2022
• First Posted: February 11, 2022
• Study Start: April 1, 2020
• Primary Completion: December 30, 2020
• Study Completion: October 15, 2021
• Last Updated: February 11, 2022

Record last verified: 2022-02

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)