NCT05231915

Completed

Prevalence of the c.853delT Mutation of the HOXB13 Gene in P...

University Hospital Center of Martinique Source

Compare

Other study identifiers

Sponsor study identifier

19_RIPH2_14

Study Type

interventional

Actual enrollment (reported)

465

Locations

1 country

Sites

1

Timeline

Study Start

April 9, 2021

Actual (reported)

Primary Completion

November 27, 2024

Actual (reported)

Study Completion

March 9, 2025

Actual (reported)

Brief Summary

In Martinique, prostate cancer incidence rates are nowadays among the highest worldwide with a high incidence of early-onset and familial forms. We identified a rare heterozygous germline variant c.853delT (p.Ter285Lysfs) rs77179853, reported only among patients of African ancestry with a minor allele frequency of 3.2%. We search to estimate the prevalence of this variant in a sample of prevalent prostate cancer cases managed in urology consultation in Martinique .

Registry Overview

Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.

Recruitment status: completed
Actual enrollment (reported): 465 participants
Study completion date: March 9, 2025
Actual (reported)
Listed locations: 1 countries · 1 sites

Trial Relationships

Click on a node to explore related trials.

Some registry-reported names shown below are not yet linked in this graph.

Study Timeline

Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.

Study Start
April 9, 2021
Actual (reported)
First Submitted
February 1, 2022
Actual (reported)
First Posted
February 9, 2022
Actual (reported)
Primary Completion
November 27, 2024
Actual (reported)
Study Completion
March 9, 2025
Actual (reported)

Last Updated: March 31, 2026
Status Verified: March 2026
Last Update Submitted: March 26, 2026

Conditions

Prostate Cancer

Keywords

Prostate cancerMartiniqueHOXB13 c.853delT prevalence

Outcome Measures

Primary Outcomes (1)

Estimation of prevalence of Allelic frequency of the HOXB13 c.853delT mutation
Mutation is detected using Next Generation Sequencing (NGS) technique
At baseline

Study Arms (1)

HOXB13 c.853delT mutation

OTHER

Mutation is detected using Next Generation Sequencing (NGS) technique

Genetic: HOXB13 c.853delT mutation

Interventions

HOXB13 c.853delT mutationGenetic

Identify the Allelic frequency of the HOXB13 c.853delT mutation in patients with a cancer prostate in Martinique

HOXB13 c.853delT mutation

Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.

Eligibility Criteria

Age18 Years+

Sexmale

Healthy VolunteersNo

Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

Adult man over 18 years of age living in Martinique with a prostate cancer whatever the histological type and the stage, managed in urology consultation (public and private sectors of Martinique)
Sporadic or familial form

Sponsors & Collaborators

University Hospital Center of Martinique
Otherlead

Study Sites (1)

Centre Hospitalier Universitaire de Martinique

Fort-de-France, 97261, Martinique

MeSH Terms

Conditions

Prostatic Neoplasms

Condition Hierarchy (Ancestors)

Genital Neoplasms, MaleUrogenital NeoplasmsNeoplasms by SiteNeoplasmsGenital Diseases, MaleGenital DiseasesUrogenital DiseasesProstatic DiseasesMale Urogenital Diseases

Enrollment

465 participants (actual enrollment reported by the registry).

Study Design

Study Type: interventional
Phase: not applicable
Allocation: NA
Masking: NONE
Purpose: SCREENING
Intervention Model: SINGLE GROUP
Sponsor Type: OTHER
Responsible Party: SPONSOR

Study Record Dates

First Submitted

February 1, 2022

First Posted

February 9, 2022

Study Start

April 9, 2021

Actual (reported)

NCT03823001

Virtual Prostate Biopsy Protocol for Patients on Active Surveillance and at Risk of Prostate Cancer

Not ApplicableWithdrawn

NCT04322045

Combined Prostate-specific Antigen, Multi-parametric MRI and Targeted Prostate Biopsy for Prostate Cancer Screening

Not ApplicableUnknown

NCT04231006

Salvage HDR for Locally Recurrent Prostate Cancer

Not ApplicableRecruiting

NCT04745871

Diagnostic Performance of PSMA PET/CT for Pre-operative Lymph Node Assessment in Intermediate and High-risk Non-metastasic Prostate Cancer (PREOP-PSMA ).

Not ApplicableTerminated

NCT05500846

Targeted Cryoablation of Prostate Cancer Lesions: An Investigator-initiated Trial

Not ApplicableUnknown

NCT04087980

Ablation of Prostate Tissue Utilizing Sterile Water Vapor in Patients With Intermediate Risk Localized Prostate Cancer

Not ApplicableCompleted

Informed with a written consent signed by the participant and the investigator

Affiliate or beneficiary of french social security.

You may not qualify if:

Patient who is not of African descent
Refusal to participate.
Patients not affiliated to french social security

Contact the study team to confirm eligibility.

Primary Completion

November 27, 2024

Actual (reported)

Study Completion

March 9, 2025

Actual (reported)

Last Updated

March 31, 2026

Record last verified: 2026-03

Data Sharing

IPD Sharing: Will not share

Source record

Download the complete ClinicalTrials.gov record imported by Syfrah, including fields not shown in this page. The registry may contain a newer revision.

Source: ClinicalTrials.gov.

JSON downloads include source attribution and retrieval details alongside the unchanged original record or the separately normalized values.

Registry identifier: NCT05231915
Data provider: ClinicalTrials.gov
Source updated: 2026-03-31
Normalization version: ctgov-legacy-1

Open registry record

Source retrieved: 2026-10-25 22:39:18 UTC

Locations

MQ(1)

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

Study Start

First Submitted

First Posted

Primary Completion

Study Completion

Conditions

Keywords

Outcome Measures

Primary Outcomes (1)

Study Arms (1)

HOXB13 c.853delT mutation

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

MeSH Terms

Conditions

Condition Hierarchy (Ancestors)

Enrollment

Study Design

Study Record Dates

You may not qualify if:

Data Sharing

Source record

Locations