Prevalence of the c.853delT Mutation of the HOXB13 Gene in Prostate Cancer in Martinique

NCT05231915 | Completed

• 1 other identifier: 19_RIPH2_14
• Study Type: interventional
• Target: 465
• Locations: 1 country
• Sites: 1

Brief Summary

In Martinique, prostate cancer incidence rates are nowadays among the highest worldwide with a high incidence of early-onset and familial forms. We identified a rare heterozygous germline variant c.853delT (p.Ter285Lysfs) rs77179853, reported only among patients of African ancestry with a minor allele frequency of 3.2%. We search to estimate the prevalence of this variant in a sample of prevalent prostate cancer cases managed in urology consultation in Martinique .

Conditions

Prostate Cancer

Keywords

Prostate cancer; Martinique; HOXB13 c.853delT prevalence

Outcome Measures

Primary Outcomes (1)

• Estimation of prevalence of Allelic frequency of the HOXB13 c.853delT mutation

  Mutation is detected using Next Generation Sequencing (NGS) technique

  At baseline

Study Arms (1)

HOXB13 c.853delT mutation

OTHER

Mutation is detected using Next Generation Sequencing (NGS) technique

Genetic: HOXB13 c.853delT mutation

Interventions

HOXB13 c.853delT mutation GENETIC

Identify the Allelic frequency of the HOXB13 c.853delT mutation in patients with a cancer prostate in Martinique

HOXB13 c.853delT mutation

Eligibility Criteria

• Age: 18 Years+
• Sex: male
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Adult man over 18 years of age living in Martinique with a prostate cancer whatever the histological type and the stage, managed in urology consultation (public and private sectors of Martinique)
• Sporadic or familial form
• Informed with a written consent signed by the participant and the investigator
• Affiliate or beneficiary of french social security.

You may not qualify if:

• Patient who is not of African descent
• Refusal to participate.
• Patients not affiliated to french social security

Sponsors & Collaborators

• University Hospital Center of Martinique: lead

Study Sites (1)

Centre Hospitalier Universitaire de Martinique

Fort-de-France, 97261, Martinique

Location

MeSH Terms

Conditions

Prostatic Neoplasms

Condition Hierarchy (Ancestors)

Genital Neoplasms, Male; Urogenital Neoplasms; Neoplasms by Site; Neoplasms; Genital Diseases, Male; Genital Diseases; Urogenital Diseases; Prostatic Diseases; Male Urogenital Diseases

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: SCREENING
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 1, 2022
• First Posted: February 9, 2022
• Study Start: April 9, 2021
• Primary Completion: November 27, 2024
• Study Completion: March 9, 2025
• Last Updated: March 31, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will not share

Locations

MA (1)