NCT05225740|Completed
Exposure Therapy Consortium (ETC) for Anxiety Sensitivity
ETC
Large-group One-session Exposure Therapy Protocol for Targeting Anxiety Sensitivity
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ETC
Large-group One-session Exposure Therapy Protocol for Targeting Anxiety Sensitivity
Sponsor study identifier
interventional
399
4 countries
12
Study Start
October 1, 2022
Actual (reported)Primary Completion
July 1, 2024
Actual (reported)Study Completion
July 1, 2024
Actual (reported)The current study seeks to test differences between a single-session large-group format of standard exposure, enhanced exposure, and a control condition in treating anxiety sensitivity. It is hypothesized that 1) participants assigned to either exposure condition will evidence greater reductions in anxiety sensitivity from pre-treatment to posttreatment relative to those in the control condition; 2) participants assigned to the enhanced exposure condition will evidence greater reductions in anxiety sensitivity from pre-treatment to posttreatment relative to those in the standard exposure condition. The investigators will test putative moderators and mechanisms of action. Prior to initiating the study for purposes of data analyses, the investigators will pilot study procedures during Spring 2020.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
July 1, 2024
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
May 17, 2021
Actual (reported)February 4, 2022
Actual (reported)October 1, 2022
Actual (reported)July 1, 2024
Actual (reported)July 1, 2024
Actual (reported)Anxiety Sensitivity
The primary outcome is Anxiety Sensitivity at the posttreatment endpoint. Anxiety Sensitivity will be measured with the Anxiety Sensitivity Index-3 scale (ASI-3; 0-72, lower scores mean better outcome).
1 day
Change in Anxiety Sensitivity
1 month
Depression
1 month
Anxiety
1 month
General stress reduction based on stress management training to help people cope with feelings of anxiety, used as an active control condition
Psychoeducation about exposure therapy and anxiety sensitivity, interoceptive exposure therapy modeling and practice, and completion of questions about the exercises and the large-group aspect
Psychoeducation about exposure therapy and anxiety sensitivity, interoceptive exposure therapy modeling and practice, and post-exposure processing aimed at emphasizing harm expectancy violation
The standard intervention will include an orientation and psychoeducation phase, an exposure practice phase consisting five repeated trials per each of the three exposure exercises, and a post-exposure exercise. The post-exposure exercise will involve completing a set of questions regarding the exercises and the group experience.
Stress management training (SMT) is designed to help people better cope with feelings of anxiety that accompany high levels of anxiety sensitivity. SMT will involve group instruction in healthy ways to experience and cope with stress whenever difficult situations arise. Participants will teach participants ways to maintain a healthy lifestyle, targeting things like nutrition, exercise, and sleep hygiene. This intervention will also involve progressive muscle relaxation training.
The University of Colorado at Boulder
Boulder, Colorado, 80309, United States
The University of Miami
Miami, Florida, 33146, United States
Boston University
Boston, Massachusetts, 02215, United States
The University of Mississippi
Oxford, Mississippi, 38677, United States
The University of Texas at Austin
Austin, Texas, 78712, United States
University of New South Wales
Kensington, Australia
Curtin University
Perth, Australia
Jasper Smits, PhD
The University of Texas at Austin
399 participants (actual enrollment reported by the registry).
First Submitted
May 17, 2021
First Posted
February 4, 2022
Study Start
October 1, 2022
Actual (reported)STEPS - Stress Training and Engagement Via Phone-Based Systems
The enhanced intervention will include an orientation and psychoeducation phase, an exposure practice phase consisting five repeated trials per each of the three exposure exercises, and a processing exercise. The post-processing exercise will involve completing a set of questions that will highlight harm expectancy violations.
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Contact the study team to confirm eligibility.
Philipps-Universität Marburg
Marburg, Hesse, Germany
Ruhr-Universität Bochum
Bochum, Ruhr Region, Germany
Technische Universität Dresden
Dresden, Saxony, Germany
University of Göttingen
Göttingen, Germany
The Hebrew University of Jerusalem
Jerusalem, Israel
Primary Completion
July 1, 2024
Actual (reported)Study Completion
July 1, 2024
Actual (reported)Last Updated
April 29, 2025
Record last verified: 2025-04
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Source: ClinicalTrials.gov.
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