Epidemiology of Gunshot Wounds Injuries Admitted in ICU in France

NCT05224570 | Completed

• 1 other identifier: LOCAL/2021/LR-01
• Study Type: observational
• Target: 120
• Locations: 1 country
• Sites: 1

Brief Summary

In civilian practice, the incidence of firearm violence depends on the country. In high income countries, most cases are reported in the USA or South Africa. In these countries, gunshot wounds (GSW) represent 20% of death cases in trauma centers, more than motor vehicle collisions. The mortality in civilian practice occurs during the first 24 hours following GSW, mainly due to hemorrhage and traumatic brain injury, though long term effects on physical and psychological outcomes have also been shown. Some factors of mortality specific to GSW have been established: multiples wounds, homicide vs suicide attempt, impact zone, or firearm caliber. Few specific guidelines have been published concerning civilian GSW management. These cases are mostly treated in standard guidelines, such as hemorrhagic shock or traumatic brain injury guidelines. As in other trauma mechanisms, the "platinum ten minutes and golden hour" concept is applicable. In Europe, the incidence of civilian GSW is much lower and few European studies have been published recently. Penetrating injuries in Europe are less likely to be GSW, and are more often self-inflicted than in the USA. In addition, European studies are heterogeneous, due to the difference in populations, healthcare systems and GSW being grouped with stabbing wounds under the label "penetrating trauma". However, there is a global concern in Europe regarding a potential rise of GSW, with higher severity score than conventional trauma patients and often necessitate ICU admission. Studies analyzing data from different European countries show significantly different ICU admission rates for overall GSW, ranging from 17% up to 30%. Therefore, the investigators conducted a multicenter, retrospective study on four French University Hospitals aiming to describe the epidemiology (mortality and type of organ damage) and identify prognosis factors of civilian GSW admitted in ICU.

Conditions

Gunshot Wound

Outcome Measures

Primary Outcomes (1)

• Mortality

  mortality rate at day 28 of patients admitted for Gunshot wounds

  day 28

Secondary Outcomes (12)

• Age

  Day 0

• Sex

  Day 0

• Comorbidity

  Day 0

• Type of gunshot

  Day 0

• Bullet impact zone

  Day 0

Study Arms (1)

Gunshot wounds admitted in ICU

patient with Gunshot wounds admitted to ICU

Eligibility Criteria

• Age: 15 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All patients who were admitted for gunshot wound care in ICU between 1st of January 2015 and June 30th 2021 at Nîmes University Hospital, Marseille North University Hospital, Montpellier DAR\_A University Hospital, Toulon Military Teaching Hospital.

You may qualify if:

• Admission for gunshot wound care in ICU between 1st of January 2015 and June 30th 2021 at Nimes University Hospital, Marseille North University Hospital, Montpellier University Hospital, Toulon Military Teaching Hospital.
• Patient ≥ 15 years old

You may not qualify if:

• Patient \< 15 years old
• Patient who objected to the use of their data.

Sponsors & Collaborators

• Centre Hospitalier Universitaire de Nīmes: lead

Study Sites (1)

CHU de NIMES

Nîmes, 30029, France

Location

Related Publications (1)

• Rougerie L, Charbit J, Mezzarobba M, Leone M, Duclos G, Meaudre E, Cungi PJ, Bartoli C, Thierry GR, Roger C, Muller L. Epidemiology of civilian's gunshot wound injuries admitted to intensive care unit: A retrospective, multi-center study. Injury. 2024 Oct;55(10):111735. doi: 10.1016/j.injury.2024.111735. Epub 2024 Jul 25.

  PMID: 39153311 RESULT

MeSH Terms

Conditions

Wounds, Gunshot

Condition Hierarchy (Ancestors)

Wounds, Penetrating; Wounds and Injuries

Study Officials

• Loic ROUGERIE

  CHU NIMES

  PRINCIPAL INVESTIGATOR

• Laurent MULLER, Md, PhD

  CHU NIMES

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 16, 2021
• First Posted: February 4, 2022
• Study Start: January 1, 2015
• Primary Completion: June 17, 2022
• Study Completion: June 17, 2022
• Last Updated: December 4, 2025

Record last verified: 2022-01

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)