Home Air Quality Impact for Adults With Asthma

NCT05224076 | Completed Results

• 2 other identifiers: STUDY00145830R21ES033118
• Study Type: observational
• Target: 64
• Locations: 1 country
• Sites: 1

Brief Summary

The purposes of this study are to determine the practicality of using home indoor air quality monitoring and a smartphone app to identify home air quality changes and how these changes affect adults with asthma.

Conditions

Asthma; Environmental Exposure; Home Environment Related Disease

Keywords

volatile organic compounds; particulate matter; home air quality; asthma control; ecological momentary assessment; home air quality monitoring; smartphone technology; home spirometry

Outcome Measures

Primary Outcomes (2)

• Episodes Per Day

  Number of episodes per day that the residential VOCs exceeded 333 ppb and/or PM2.5 exceeded 15 mg/m3, as measured by the Awair home air quality monitor

  Measured daily for 14 days

• Home Spirometry Completed

  Number of participants completing daily home spirometry over 14 days.

  Assessed daily for 14 days

Secondary Outcomes (2)

• Integration of Study Components

  14 days

• Ecological Momentary Assessment (EMA) Surveys

  14 days

Interventions

Home Air Quality OTHER

This study will assess the feasibility and usability of ecological momentary assessment (EMA) to capture the context of real time behaviors and environmental exposures that impact indoor environments. In addition, the study will assess the feasibility and usability of providing participants with a readily available indoor home air quality monitor to continuously capture total volatile organic compounds (VOCs) and particulates (PM2.5).

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Adults with asthma living in the US

You may qualify if:

• Adults who previously participated in the online Global Covid-19 and Asthma Study, indicated willingness to be contacted for future research, and reported high use of disinfectant/cleaning products since COVID-19 (≥5 per week).
• Current Asthma Control Test (ACT) ≤19
• Own a smartphone
• Have a Wi-Fi/wireless internet connection in their home.

You may not qualify if:

• Non-US residents
• Non-English speaking

Sponsors & Collaborators

• University of Kansas Medical Center: lead
• National Institute of Environmental Health Sciences (NIEHS): collaborator

Study Sites (1)

Barbara J Polivka

Kansas City, Kansas, 66160, United States

Location

Related Publications (6)

• Eldeirawi K, Huntington-Moskos L, Nyenhuis SM, Polivka B. Increased disinfectant use among adults with asthma in the era of COVID-19. J Allergy Clin Immunol Pract. 2021 Mar;9(3):1378-1380.e2. doi: 10.1016/j.jaip.2020.12.038. Epub 2020 Dec 29. No abstract available.

  PMID: 33385592 BACKGROUND

• Matulonga B, Rava M, Siroux V, Bernard A, Dumas O, Pin I, Zock JP, Nadif R, Leynaert B, Le Moual N. Women using bleach for home cleaning are at increased risk of non-allergic asthma. Respir Med. 2016 Aug;117:264-71. doi: 10.1016/j.rmed.2016.06.019. Epub 2016 Jun 25.

  PMID: 27492540 BACKGROUND

• Le Moual N, Varraso R, Siroux V, Dumas O, Nadif R, Pin I, Zock JP, Kauffmann F; Epidemiological Study on the Genetics and Environment of Asthma. Domestic use of cleaning sprays and asthma activity in females. Eur Respir J. 2012 Dec;40(6):1381-9. doi: 10.1183/09031936.00197611. Epub 2012 Apr 10.

  PMID: 22496323 BACKGROUND

• Zock JP, Plana E, Jarvis D, Anto JM, Kromhout H, Kennedy SM, Kunzli N, Villani S, Olivieri M, Toren K, Radon K, Sunyer J, Dahlman-Hoglund A, Norback D, Kogevinas M. The use of household cleaning sprays and adult asthma: an international longitudinal study. Am J Respir Crit Care Med. 2007 Oct 15;176(8):735-41. doi: 10.1164/rccm.200612-1793OC. Epub 2007 Jun 21.

  PMID: 17585104 BACKGROUND

• Gharpure R, Hunter CM, Schnall AH, Barrett CE, Kirby AE, Kunz J, Berling K, Mercante JW, Murphy JL, Garcia-Williams AG. Knowledge and Practices Regarding Safe Household Cleaning and Disinfection for COVID-19 Prevention - United States, May 2020. MMWR Morb Mortal Wkly Rep. 2020 Jun 12;69(23):705-709. doi: 10.15585/mmwr.mm6923e2.

  PMID: 32525852 BACKGROUND

• Nyenhuis S, Cramer E, Grande M, Huntington-Moskos L, Krueger K, Bimbi O, Polivka B, Eldeirawi K. Utilizing Real-time Technology to Assess the Impact of Home Environmental Exposures on Asthma Symptoms: Protocol for an Observational Pilot Study. JMIR Res Protoc. 2022 Aug 2;11(8):e39887. doi: 10.2196/39887.

  PMID: 35916686 DERIVED

MeSH Terms

Conditions

Asthma

Condition Hierarchy (Ancestors)

Bronchial Diseases; Respiratory Tract Diseases; Lung Diseases, Obstructive; Lung Diseases; Respiratory Hypersensitivity; Hypersensitivity, Immediate; Hypersensitivity; Immune System Diseases

Limitations and Caveats

This was a feasibility study with a small sample thus potentially limiting generalizability.

Results Point of Contact

• Title: Dr. Barbara Polivka
• Organization: University of Kansas School of Nursing

bpolivka@kumc.edu

6142049915

Study Officials

• Barbara Polivka, PhD

  Select

  PRINCIPAL INVESTIGATOR

Publication Agreements

• PI is Sponsor Employee: No
• Restrictive Agreement: No

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 10, 2022
• First Posted: February 4, 2022
• Study Start: March 30, 2022
• Primary Completion: February 28, 2024
• Study Completion: February 28, 2024
• Last Updated: July 29, 2025
• Results First Posted: July 29, 2025

Record last verified: 2025-07

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, ICF, CSR, ANALYTIC CODE
• Time Frame: Up to 24 months after the publication of the main study findings.
• Access Criteria: Requests for IPD will be reviewed by the MPIs once a formal email request is submitted for research addressable aims/questions/hypotheses. Once the request has been approved by the MPIs and IRB approval is obtained, only deidentified data relevant to the research questions will be shared for secondary analyses deemed appropriate by the MPIs.

Locations

US (1)