Re-Orchestration of Interregional Oscillatory Activity to Promote Visual Recovery

NCT05220449 | Active Not Recruiting

• 1 other identifier: 2017-01761
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

This project assesses the effect of bifocal cross-frequency transcranial alternating current stimulation (tACS) combined with visual training to improve visual recovery and orchestrated oscillatory activity in stroke patients suffering from visual field defects.

Conditions

Visual Impairment; Stroke; Parkinson Disease

Keywords

Stroke; Visual field; Oscillations; tACS; Parkinson's Disease

Outcome Measures

Primary Outcomes (1)

• Changes in visual field functions

  Comparison of the systematic measurement of the visual field using Humphrey perimetry

  Measured at baseline (i.e. before the first day of intervention), and post intervention (i.e., after the last day of intervention)

Secondary Outcomes (4)

• Changes in motion discrimination and integration performances

  Measured at baseline (i.e. before the first day of intervention), and post intervention (i.e., after the last day of intervention)

• Changes in inter-areal cross-frequency interaction

  Measured at baseline (i.e. before the first day of intervention), and post intervention (i.e., after the last day of intervention)

• Changes in visual tracts integrity

  Measured at baseline (i.e. before the first day of intervention), and post intervention (i.e., after the last day of intervention)

• Changes in functional connectivity within the broad visual network

  Measured at baseline (i.e. before the first day of intervention), and post intervention (i.e., after the last day of intervention)

Study Arms (2)

Cf-tACS (V1-Alpha_V5-Gamma)

ACTIVE COMPARATOR

Other: Cross-frequency dual-site tACS

Cf-tACS (V1-Gamma_V5-Alpha)

EXPERIMENTAL

Other: Cross-frequency dual-site tACS

Interventions

Cross-frequency dual-site tACS OTHER

Dual site transcranial alternating current stimulation over the primary visual cortex (V1) and the mediotemporal cortex (MT/V5) using two different stimulation frequencies (Alpha and Gamma)

Cf-tACS (V1-Alpha_V5-Gamma); Cf-tACS (V1-Gamma_V5-Alpha)

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• the patient can consent for themselves;
• age 18+ years old;
• at least 7 days since diagnosis "stroke".
• Patients should demonstrate a clear deficit in either simple or complex visual perception in portions of their visual field

You may not qualify if:

• Diminished capacity to consent;
• Pregnancy
• Known or suspected non-compliance, drug or alcohol abuse
• Inability to follow the procedures of the study, e.g., due to language problems, psychological disorders, dementia, etc. of the participant,
• Non-compliance to the instructions of the experimenter or an inappropriate behavior hindering the normal progress of the experiment.
• Previous enrolment into the current study
• Use of psychoactive medication

Sponsors & Collaborators

• Ecole Polytechnique Fédérale de Lausanne: lead

Study Sites (1)

Campus Biotech, EPFL

Geneva, 1201, Switzerland

Location

MeSH Terms

Conditions

Vision Disorders; Stroke; Parkinson Disease

Condition Hierarchy (Ancestors)

Sensation Disorders; Neurologic Manifestations; Nervous System Diseases; Eye Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases; Parkinsonian Disorders; Basal Ganglia Diseases; Movement Disorders; Synucleinopathies; Neurodegenerative Diseases

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: INVESTIGATOR
• Masking Details: Double (Participant \& Investigator)
• Purpose: TREATMENT
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Teaching and Research Associate

Study Record Dates

• First Submitted: November 30, 2021
• First Posted: February 2, 2022
• Study Start: September 1, 2017
• Primary Completion: August 1, 2023
• Study Completion: December 1, 2025
• Last Updated: August 28, 2024

Record last verified: 2024-08

Locations

CH (1)