Delirium and EuroSCORE II in Cardiac Surgery

NCT05218720 | Completed Results

• 1 other identifier: 2021-6153-19008
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this observational study is to find out the association between EuroSCORE II of Delirium in patients undergoing cardiac surgery. The main questions it aims to answer are the incidence of Delirium in patients undergoing cardiac surgery and to find the association of EuroSCORE II with delirium in cardiac surgery patients.

Conditions

Delirium

Keywords

Cardiac Surgery; Post-operative Delirium; Coronary Artery Bypass Grafting; EuroSCORE II

Outcome Measures

Primary Outcomes (2)

• Number of Participants With Delirium

  As per DSM 5 criteria delirium is an acute condition. Symptoms begin over a few hours or a few days. Delirium will be assessed by CAM-ICU score.

  Day 1

• Association of Euroscore II Category With Delirium

  Day 1

Interventions

EuroSCORE II risk score and CAM-ICU (The Confusion Assessment Method for the Intensive Care Unit) OTHER

* EuroSCORE II is used to predict the risk of in-hospital mortality after cardiac surgery. Where very low risk is \<1, low risk is 1-2.99, moderate risk is 3-4.99, and high risk is \>5. * CAM- ICU: The Confusion Assessment Method for the Intensive Care Unit (CAM-ICU) is a tool used to assess delirium in patients in intensive care. The score ranges from 0-. Where 0-2 is no delirium, ≥ 3 is positive for delirium, 3-5 mild delirium, 6-7 severe delirium with 7 considered most severe delirium.

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients (18-80 years) undergoing elective cardiac surgeries (CABG, MVR, AVR), receiving invasive ventilation

You may qualify if:

• Age greater than or equal to 18 years
• ASA I -IV
• Patients undergoing elective cardiac surgery

You may not qualify if:

• Patients undergoing emergency cardiac surgeries
• History of stroke in the last 6 weeks
• History of delirium
• History of psychiatric illness
• history of medication for psychiatric illness
• Patients undergoing reopen surgery

Sponsors & Collaborators

• Aga Khan University: lead

Study Sites (1)

Aga Khan University Hospital

Karachi, Sindh, 74800, Pakistan

Location

Related Publications (5)

• Norkiene I, Ringaitiene D, Kuzminskaite V, Sipylaite J. Incidence and risk factors of early delirium after cardiac surgery. Biomed Res Int. 2013;2013:323491. doi: 10.1155/2013/323491. Epub 2013 Sep 12.

  PMID: 24102052 BACKGROUND

• Norkiene I, Ringaitiene D, Misiuriene I, Samalavicius R, Bubulis R, Baublys A, Uzdavinys G. Incidence and precipitating factors of delirium after coronary artery bypass grafting. Scand Cardiovasc J. 2007 Jun;41(3):180-5. doi: 10.1080/14017430701302490.

  PMID: 17487768 BACKGROUND

• Koster S, Oosterveld FG, Hensens AG, Wijma A, van der Palen J. Delirium after cardiac surgery and predictive validity of a risk checklist. Ann Thorac Surg. 2008 Dec;86(6):1883-7. doi: 10.1016/j.athoracsur.2008.08.020.

  PMID: 19022003 BACKGROUND

• Theologou S, Giakoumidakis K, Charitos C. Perioperative predictors of delirium and incidence factors in adult patients post cardiac surgery. Pragmat Obs Res. 2018 May 8;9:11-19. doi: 10.2147/POR.S157909. eCollection 2018.

  PMID: 29773957 BACKGROUND

• European Delirium Association; American Delirium Society. The DSM-5 criteria, level of arousal and delirium diagnosis: inclusiveness is safer. BMC Med. 2014 Oct 8;12:141. doi: 10.1186/s12916-014-0141-2.

  PMID: 25300023 BACKGROUND

MeSH Terms

Conditions

Delirium; Emergence Delirium

Condition Hierarchy (Ancestors)

Confusion; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Neurocognitive Disorders; Mental Disorders; Postoperative Complications; Pathologic Processes

Results Point of Contact

• Title: Dr Khalid Siddiqui
• Organization: Aga Khan University Hospital

khalid.siddiqui@aku.edu

+922134864630

Publication Agreements

• PI is Sponsor Employee: No
• Restrictive Agreement: No

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: January 31, 2022
• First Posted: February 1, 2022
• Study Start: March 1, 2022
• Primary Completion: May 23, 2023
• Study Completion: May 24, 2024
• Last Updated: May 8, 2026
• Results First Posted: May 8, 2026

Record last verified: 2026-05

Locations

PA (1)