Triglyceride Effects on Blood Flow in the Human Brain

NCT05218018 | Completed Results

• 2 other identifiers: STUDY000084511R01AG067563-01
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

The 'Western diet' characterized by high fat feeding (HFF) is a risk factor for Alzheimer's disease (AD); however, little is known about mechanisms. Paradoxically, individuals who carry the AD risk gene APOE E4 cognitively improve after HFF and show different metabolic responses to fat intake. These responses include a more pronounced drop in systolic blood pressure and a decrease in cerebrospinal fluid glucose and lactate levels. This proposal will further examine the brain metabolic response to HFF using non-invasive imaging. Cerebral blood flow (CBF) as assessed by functional MRI is increasingly utilized to investigate brain function, given that CBF is tightly coupled to brain metabolism. Acute changes in CBF have been described in response to carbohydrate ingestion in regions important for learning and memory; however, no one has yet assessed CBF response to lipid. Here investigators propose to characterize CBF changes to a high fat drink in older adults. This study will include a time course assessment as well as analyses of global and regional change in CBF. These data would serve as feasibility pilot data for an R01 application which would include cognitive and peripheral metabolic data. These types of studies will provide a clearer picture of acute brain metabolic response to HFF in older adults, including the effects of APOE.

Conditions

Alzheimer Disease

Outcome Measures

Primary Outcomes (2)

• Cerebral Blood Flow Global

  Change from Baseline in Cerebral Blood Flow Global at 2 Hours

  Value at 2 hours minus value at baseline

• Cerebral Blood Flow Change Scores

  Change from Baseline in Cerebral Blood Flow Global at 1, 2 and 3 Hours Post Lipid Drink

  1 hour minus baseline, 2 hours minus baseline, and 3 hours minus baseline

Study Arms (1)

Intervention

OTHER

Only one arm of study

Dietary Supplement: Lipid drink

Interventions

Lipid drink DIETARY_SUPPLEMENT

100 mls of heavy cream

Intervention

Eligibility Criteria

• Age: 55 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Previously completed the Meal and Memory study
• Age 55 and older
• Able to read and understand English
• Able to give informed consent
• Able to undergo MRI and ingest dairy products

You may not qualify if:

• Did not screen in the Meal and Memory study
• Allergic to or not able to ingest study ingredient (dairy)
• Metal in body or otherwise unable to lay still for an MRI

Sponsors & Collaborators

• University of Washington: lead
• National Institute on Aging (NIA): collaborator

Study Sites (1)

University of Washington Medical Center

Seattle, Washington, 98104, United States

Location

MeSH Terms

Conditions

Alzheimer Disease

Condition Hierarchy (Ancestors)

Dementia; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Tauopathies; Neurodegenerative Diseases; Neurocognitive Disorders; Mental Disorders

Results Point of Contact

• Title: Angela Hanson
• Organization: University of Washington

hansonaj@uw.edu

206-897-5393

Study Officials

• Angela J Hanson, MD

  University of Washington

  PRINCIPAL INVESTIGATOR

Publication Agreements

• PI is Sponsor Employee: Yes

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: OTHER
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor, School of Medicine

Model Details: All participants undergo the same intervention

Study Record Dates

• First Submitted: December 20, 2021
• First Posted: February 1, 2022
• Study Start: March 1, 2020
• Primary Completion: January 13, 2022
• Study Completion: January 13, 2022
• Last Updated: February 8, 2023
• Results First Posted: February 8, 2023

Record last verified: 2023-01

Locations

US (1)